My Research
Factors that benefit GBM
Genetics and Epidemiology
Glioblastomas develop due to mutations in genes that allow for conditions such as excessive growth and proliferation to occur. Few mutations are considered key features that lead to GBM, including EGFR, IDH1, MGMT, TP53, and NF1. It is considered one of the most common brain tumors with 12,000 cases diagnosed per year in the United States alone.
Brain parts involved and Pathology
Glioblastomas typically develop from glial cells which help maintain and strengthen neurons. These tumors can originate from other cancers that metastasized (secondary GBM) or they originate within glial cells themselves (primary or 'de novo'). Depending on the area the tumor proliferates in, it can inhibit the function of that area, and overall impacts the brain negatively due to taking excessive resources from other regions.
Tools for Research and Development
Cell Cultures
Animal models (Mice Models, GEMM)
Neuroimaging
Diagnosis, Screening and Prevention
Radiogenomics
fMRI
MR Spectroscopy
Perfusion Weighted Imaging
Subtyping
Primary ("de novo") vs Secondary
proneural, mesenchymal, classical
Biomarkers :
IDH1 Mutation
MGMT Mutation
Disease Management:
Surgical Resection
Temozolomide
Radiogenomics
Outlook and Future Direction
CAR-T Cell Therapy
IDH1 Vaccine
Artifical Neural Networks