Publication

https://eprints.lib.hokudai.ac.jp/dspace/simple-search?query=hinou&submit&lang=en (HUSCUP, Hokkaido Univ)

https://orcid.org/0000-0003-2223-7300

https://www.scopus.com/authid/detail.uri?authorId=6602514722

https://scholar.google.com/citations?user=fVn4VaQAAAAJ&hl=ja&oi=ao

Original papers 

1. Urakami S., Hinou H.* “MALDI glycotyping of O-antigens from a single colony of gram-negative bacteria” Scientific Reports, in press.

2. Feleke D. G., Montalban B. M., Gizaw S. T., Hinou H.* “Sulfated N-glycans Upregulation in Sera Predicts Early-Stage Breast Cancer in Patients” medRxiv (Oncology; preprint) 2024/03/28. 10.1101/2024.03.27.24305000

3. Montalban B. M., Hinou H.* “Glycoblotting-Based Ovo-Sulphoglycomics Reveals Phosphorylated N-Glycans as a Possible Host Factor of AIV Prevalence in Waterfowls” ACS Infectious Diseases, 10, 650-661, 2024. 10.1021/acsinfecdis.3c00520

4. Urakami S., Hinou H.* “Sodium-Doped 3-Amino-4-Hydroxybenzoic Acid: Rediscovered Matrix for Direct MALDI Glycotyping of O-linked Glycopeptides and Intact Mucins” Int. J. Mol. Sci. 24, 16836, 2023. 10.3390/ijms242316836  

5. Wakui H., Yokoi Y., Horidome C., Ose T., Yao M., Tanaka Y., Hinou H., Nishimura S-I.* “Structural and molecular insight into antibody recognition of dynamic neoepitope in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes” , RSC Chem. Biol. 4, 564-572, 2023.  10.1039/D3CB00036B

6. Montalban, B. M., Hinou H.*“Glycoblotting Enables Seamless and Straightforward Workflow for MALDI-TOF/MS-based Sulphoglycomics of N- and O-glycans” PROTEOMICS,  23, 2300012, 2023.  10.1002/pmic.202300012

7. Villones Jr. L. L., Ludwig A.-K., Kikuchi S., Ochi R., Nishimura S.-I., Gabius H.-J., Kaltner H.*, Hinou H.* “Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ” ChemBioChem, e202200783, 2023. 10.1002/cbic.202200783

8. Villones Jr. L. L., Ludwig A.-K., Kumeta H., Kikuchi S., Ochi R., Aizawa T., Nishimura S.-I., Gabius H.-J.*, Hinou H.* “Exploring the In situ Pairing of Human Galectins toward Synthetic O-Mannosylated Core M1 Glycopeptides of α-Dystroglycan” Scientific Reports, 12, 17800, 2022. 10.1038/s41598-022-22758-0 

9. Barada E., Hinou H.* “BOA/DHB/Na: an Efficient UV-MALDI Matrix for High-Sensitivity and Auto-Tagging Glycomics” Int. J. Mol. Sci, 23, 12510, 2022. 10.3390/ijms232012510 

10. Urakami S., Hinou H.* “Direct MALDI Glycotyping of Glycoproteins Toward Practical Subtyping of Biological Samples”ACS Omega, 7, 39280-39286, 2022. 10.1021/acsomega.2c05429

11. Matsushita T., Hinou H., Nishimura S.-I.* “Generation 6 polyamidoamine dendrimer provides an ideal nanoparticular platform for enzyme-assisted synthesis of glycopeptides having bulky and complex glycans” Chemistry Letters, 51, 1044-1048, 2022. 10.1246/cl.220344 

12. Shiratori K., Yokoi Y., Wakui H., Hirane N., Otaki M., Hinou H., Yoneyama T., Kimura S., Hatakeyama S., Ohyama C., Nishimura S.-I.* “Selective reaction monitoring approach using structure-defined synthetic glycopeptides for validating glycopeptide biomarkers pre-determined by bottom-up glycoproteomics” RSC Advances, 12, 21385-21393, 2022. 10.1039/D2RA02903K

13. Urakami S., Hinou H.* “Glycan Selective MALDI In-source Decay Analysis of Intact Glycoprotein”Analysis & Sensing, 2022, vol. 2, eLoc. e202100040 10.1002/anse.202100040  Most Accessed 03/2022 Top Downloaded

14. Carbajo-Gordillo, Ana; Jimenez Blanco, Jose; Benito, Juan; Lana, Hugo; Marcelo, Gema; Di Giorgio, Christophe; Przybylski, Cédric; Hinou, Hiroshi; Ceña, Valentín; Ortiz Mellet, Carmen; Mendicuti, Francisco; Tros de ILarduya, Conchita; García Fernández, José “Click Synthesis of Size and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery” Biomacromolecules 21, 5173-5188, 2020. 10.1021/acs.biomac.0c01283

15. Guillen-Poza P. A., Sanchez-Fernandez E. M., Artigas G., Fernandez J. M. G., Hinou H., Mellet C. O., Nishimura S.-I., Garcia-Martin F.* “Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics.” J. Med. Chem. 63, 8524-8533 (2020). 10.1021/acs.jmedchem.0c00908 

16. Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Min Y., Tachibana T., Sato M., Naruchi K., Martin F. G., Hinou H., Nishimura S.-I.* “A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes.” Chem. Sci. 11, 4999-5006 (2020).10.1039/D0SC00317D 

17. Bermejo I. A., Navo C. D., Castro-López J., Guerreiro A., Fernández E. M. S., García-Martín F., Hinou H., Nishimura S.-I., Fernández J. M. G., Mellet C. O., Avenoza A.,  Busto J. H., Bernardes G. J. L., Hurtado-Guerrero R., Peregrina J. M., Corzana F.* “Synthesis, Conformational Analysis and in vivo Assays of an Anti-cancer Vaccine that features an Unnatural Antigen based on a sp2-Iminosugar Fragment” Chem. Sci. 11, 3996-4006 (2020). 10.1039/C9SC06334J 

18. Hayakawa S., Matsushita T., Yokoi Y., Wakui H., Garcia-Martin F., Hinou H., Matsuoka K., Nouso K., Kamiyama T., Taketomi A, Nishimura S-I.* “Impaired O‑Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes”. Biochemistry 59, 1221-1241 (2020). 10.1021/acs.biochem.0c00007 

19. Hideshima S.,* Hayashi H., Hinou H., Nambuya S, Kuroiwa S., Nakanishi T., Momma T., Nishimura S.-I., Sakoda Y., Osaka T.* “Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles” Scientific Reports 443, 11616, (2019). 10.1038/s41598-019-48076-6

20. Hinou H.* “Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides” Int. J. Mass Specytom., 443, 109-115 (2019). 10.1016/j.ijms.2019.06.006 

21. Hinou H.,* Kikuchi S., Ochi R., Igarashi K., Takada W., Nishimura S-I. “Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification”, Bioorg. Med. Chem., 27, 2822-2831 (2019). 10.1016/j.bmc.2019.05.008 

22. Gebrehiwot A. G., Seifu M. D., Mamo K. Y., Gemechu T., Lako W., Hinou H., Nishimura S-I.* “Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women” BMC Cancer, 19, 588 (2019). 10.1186/s12885-019-5817-8  

23. Sanes J. T., Hinou H., Lee Y. C., Nishimura S.-I.* “Glycoblotting of Egg White Reveals Diverse N-Glycan Expression in Quail Species” J. Agr. Food Chem. 67, 531-540 (2019). 10.1021/acs.jafc.8b04782

24. Takayama R., Hayakawa S., Hinou H., Albericio F., Garcia-Martin F. “Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase” J. Pept. Sci. 24, e3111 (2018). 10.1002/psc.3111 

25. Yogesh K. V., Kamiyama T., Ohyama C., Yoneyama T., Nouso K., Kimura S., Hinou H., Nishimura S.-I.* “Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers” Medchemcomm, 9, 1351-1358 (2018).

26. Hammura K., Ishikawa A., Kumar H. V. R., Miyoshi R., Yokoi Y., Tanaka M., Hinou H., Nishimura S.-I.* “Synthetic Glycopeptides Allow for the Quantitation of Scarce Nonfucosylated IgG Fc N-Glycans of Therapeutic Antibody” ACS Med. Chem. Lett., 9, 889-894 (2018).

27. Gebrehiwot, A. G. Seifu M. D., Mamo K. Y., Rehan I. F., Rangappa S., Hinou H., Kamiyama T., Nishimura S-I.* “Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers” Plos One 13, (2018).

28. Artigas, G., Hinou H.,* Garcia-Martin F., Gabius H. J.,* Nishimura S.-I.* “Synthetic Mucin-Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-Regulatory Galectins in Arrays” Chem. Asian J., 12, 159-167 (2017). https://doi.org/10.1002/asia.201601420 

29. Hayakawa S., Yokoi Y., Hinou H., Nishimura S.-I. “Chemical Synthesis Demonstrates That Dynamic O-Glycosylation Regulates the Folding and Functional Conformation of a Pivotal EGF12 Domain of the Human NOTCH1 Receptor” Biochemistry, 56, 4379-4391 (2017).

30. Artigas G., Monteiro J., Hinou H., Nishimura S.-I., Lepenies B., Garcia-Martin F.* “Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile Toward Macrophage Galactose-Type Lectin (MGL) Orthologs” J. Med. Chem., 60, 9012-9021 (2017).

31. Furukawa T., Hinou H., Takeda S., Chiba H., Nishimura S.-I., Hui* S. P. “An efficient glycoblotting-based analysis of oxidized lipids in liposomes and a lipoprotein” ChemBioChem, 18, 1903-1909 (2017).

32. Hayakawa S., Yokoi Y., Hinou H., Nishimura S.-I.* “Chemical synthesis demonstrates that dynamic O-glycosylation regulates the folding and functional conformation of a pivotal EGF12 domain of the human NOTCH1 receptor” Biochemistry, 56, 4379-4391 (2017).

33. Somovilla V., Bermejo I., Albuquerque I., Martínez-Sáez N., Castro-López J., Garcia-Martin F., Compañón I., Hinou H., Nishimura S.-I., Jiménez-Barbero J., Asensio J., Avenoza A., Jesús Busto J., Hurtado-Guerrero R., Peregrina J., Bernardes G.*, Corzana F.* “The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer” Journal of the American Chemical Society, 139, 18255-18261 (2017). 

34. Ohyabu N., Kakiya K., Yokoi Y., Hinou H., Nishimura S.-I. “Convergent solid-phase synthesis of macromoleculer MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases” J. Am. Chem. Soc., 138, 8392-8395 (2016).

35. Tan R. S., Hinou H., Nishimura S.-I. “Novel β-galactosynthase - β-mannosynthase dual activity of β- galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates” RSC Advances, 6, 50833-50836 (2016).

36. Rangappa S., Artigas S. G., Miyoshi R., Yokoi Y., Hayakawa S., Garcia-Martin F., Hinou H., Nishimura S.-I. “Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats” Med. Chem. Commun., 7, 1102-1122 (2016).

37. Gizae S. T., Ohashi T., Tanaka T., Hinou H., Nishimura S.-I. “Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery” BBA-General Subject, 17, 1716-1717 (2016).

38. Hayakawa S., Koide R., Hinou H., Nishimura S.-I. “Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-glycans in the Ligand-binding Region” Biochemistry, 55, 776-787 (2016).

39. Hinou H.,* Abe Y., Hayakawa S., Naruchi K., Fujitani N., Nishimura S.-I. “Solid-phase Synthesis of C-mannosylated Glycopeptide on WSXWS Motif of Human Erythropoietin Receptor” Tetrahedron Lett., 57,791-795 (2016).

40. Rehan I. F., Ueda K., Mitani T., Amano M., Hinou H., Ohashi T., Kondo S., Nishimura S.-I. “Large- Scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows” J. Agric. Food Chem., 63,10578-10590 (2015).

41. Tan R., Naruchi K., Amano M., Hinou H., Nishimura S.-I. “Rapid endolysosomal escape and controlled intracellular trafficking of cell surface mimetic quantum dots-anchored peptides and glycopeptides” ACS Chemical Biology, 10, 2073-2086 (2015).

42. Coelho H., Matsushita T., Artigas G., Hinou H., Canada F. J., Lo-man R., Leclerc C., Cabrita E. J., Jimenez-Barbero J., Nishimura S.-I., Garcia-Martin F., Marcelo F. “The quest for anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related monoclonal antibodies by combining microarray screening and saturation transfer difference NMR”, J. Am. Chem. Soc., 137, 12438-12441 (2015).

43. Gizae S., Koda T., Amano M., Kamimura K., Ohashi T., Hinou H., Nishimura S.-I. “A comprehensive glycome profiling of Huntington's disease transgenic mice” BBA-General Subject, 1850, 1704-1718 (2015).

44. Garcia-Martin F., Matsushita T., Hinou H., Nishimura S.-I. “Fast Epitope Mapping for the Anti-MUC1 Monoclonal Antibody by Combining a One-Bead-One-Glycopeptide Library and a Microarray Platform” Chemistry: A Europian Journal, 20, 15891-15902 (2014).

45. Ishida J., Hinou H., Naruchi K., Nishimura S.-I.* “Synthesis of neoglycophingolipids from methoxyamino-functionalized ceramide” Bioorg. Med. Chem. Lett., 24, 1197-1200, (2014).

46. Matsushita T., Takada W., Igarashi K., Naruchi K., Garcia-Martin F., Amano M., Hinou H., Nishimura S.-I.* “A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides” BBA-General Subject, 1840, 1105-1116 (2014).

47. Kumar H. V. R., Naruchi K., Miyoshi R., Hinou H., Nishimura S.-I.* “A New Approach for the Synthesis of Hyper-Branched N-Glycan Core Structures from Locust Bean Gum” Organic Letters, 15, 6278-6281 (2013).

48. Hideshima S., Hinou H., Ebihara D., Sato R., Kuroiwa S., Nakanishi T., Nishimura S.-I., Osaka T.* “Attomolar-level Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-blotted Field Effect Transistor Biosensor” Analytical Chemistry, 85, 5641-5644 (2013).

49. Izumi R., Matsushita T., Fujitani N., Naruchi K., Shimizu H., Tsuda S., Hinou H., Nishimura S.-I.* “Microwave-assisted solid-phase synthesis of antifreeze glycopeptides” Chem. Euro. J., 19, 3913-3920 (2013).

50. Nishimura S.-I.*, Matsushita T., Handa S., Naruchi K., Garcia-Martin F., Hinou H. "A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications" Polymer Journal, 45, 854-862 (2013).

51. Matsushita T., Ohyabu N., Fujitani N., Naruchi K., Shimizu H., Hinou H., Nishimura S.-I.* “Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for anti-KL-6 monoclonal antibody” Biochemistry, 52, 402-414 (2013).

52. Kai H., Hinou H.*, Naruchi K., Matsushita T., Nishimura S.-I.* “Macrocyclic Mechanism-based Inhibitor for Neuraminidases” Chem. Euro. J., 19, 1364-1372 (2013).

53. Furukawa T., Arai M., Garcia-Martin F., Amano M., Hinou H., Nishimura S.-I.* “Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation” Glycoconjugate J., 30, 171-182 (2013).

54. Furukawa T., Hinou H.*, Nishimura S.-I. “Strict stereocontrol by 2,4-O-di-tert-butylsilylene group on β-glucuronylations” Organic Lett., 14, 2102-2105 (2012).

55. Kai H., Hinou H.*, Nishimura S.-I. “Aglycone-focused randomization of 2-difluoromethylphenylsialoside-type suicide substrates for neuraminidases” Bioorg. Med. Chem., 20, 2739-2746 (2012).

56. Hinou H.*, Hyugaji K., Garcia-Martin F., Nishimura S.-I., Albericio F.* “H-Bonding Promotion of Peptide Solubility and Cyclization by Fluorinated Alcohol” RSC Advances, 2, 2729-2731 (2012).

57. Hoshi H., Shimawaki K., Takegawa Y., Oyanagi T., Amano M., Hinou H., Nishimura S.-I.* “Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes” Biochim. Biophys. Acta, 1820, 1391-1398 (2012).

58. Garcia-Martin F., Hinou H., Matsushita T., Hayakawa S., Nishimura S-I.* "An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation" Org. Biomol. Chem., 10, 1612-1617 (2012).

59. Furukawa T., Hinou H.*, Shimawaki K., Nishimura S.-I.* “A Potential Glucuronate Glycosyl Donor with 2-O-acyl-6,3-lactone Structure: Efficient Synthesis of Glycosaminoglycan Disaccharides” Tetrahedron Lett., 52, 5567-5570 (2011).

60. Ohyanagi T., Nagahori N., Shimawaki K., Hinou H., Yamashita T., Sasaki A., Jin T., Iwanaga T., Kinjo M., Nishimura S.-I.* "Importance of sialic acid residues illuminaterd by live animal imaging using phosphorylcholine self-assembled monolayers-coated quantum dots" J. Am. Chem. Soc., 133, 12507-12517 (2011).

61. Hinou H.*, Saito N., Maeda T., Matsuda M., Kamiya Y., Nishimura S.-I.* “Toward Green and Sustainable Chemical Glycosylation: Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO4/ZrO2 by CaCl2 Doping” J. Carbohydr. Chem., 30, 575-586 (2011).

62. Hinou H.*, Miyoshi R., Takasu Y., Kai H., Kurogochi M., Arioka S., Gao X.-D., Miura N., Fujitani N., Otomo S., Yoshinaga T., Fujiwara T., Noshi T., Togame H., Takemoto H., Nishimura S.-I.* "Novel Strategy for Neuraminidase Inhibitors Using Mechanism-based Labeling Information" Chem. Asian J., 6, 1048-1056 (2011).

63. Hashimoto R., Fujitani N., Takegawa T., Kurogochi M., Matsushita T., Naruchi K., Ohyabu N., Hinou H., Gao X.D., Manri N., Satake H., Kaneko A., Sakamoto T., Nishimura S.-I.* "An efficient approach for the characterization of mucin type glycopeptides: The effect of O-glycosylation on the conformation of synthetic mucin peptides" Chem. Eur. J., 17, 2393-2404 (2011).

64. Miura Y., Kato K., Takegawa Y., Kurogouchi M., Furukawa J.-i., Shinohara Y., Nagahori N., Amano M., Hinou H., Nishimura S.-I.* ”Glycoblotting-assisted O-glycomics: Ammonium carbamate allows for highly efficient O-glycan release from glycoproteins” Anal. Chem., 82, 10021-10029, (2010).

65. Matsushita T., Nagashima I., Fumoto M., Ohta T., Yamada K., Shimizu H., Hinou H., Naruchi K., Ito T., Kondo H., Nishimura S.-I.* “Artificial Golgi apparatus: Globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis”, J. Am. Chem. Soc., 132, 16651-16656 (2010).

66. Shimizu K., Hosoguchi K., Liu Y., Fujitani N., Ohta T., Hinou H., Matsushita T., Shimizu H., Feizi T., Nishimura S.-I.* "Chemical synthesis, folding and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor", J. Am. Chem. Soc., 132, 17102-17109 (2010).

67. Hosoguchi K., Maeda T., Furukawa J.-i., Shinohara Y., Hinou H., Sekiguchi M., Togame H., Takemoto H., Kondo H., and Nishimura S.-I.* "An Efficient Approach to the Discovdery of Potent Inhibitors against Glycosyltransferases", J. Med. Chem., 53, 5607-5619 (2010).

68. Yoshimura Y., Matsushita T., Fujitani N., Takegawa Y., Fujihara H., Naruchi K., Gao X-D., Manri N., Sakamoto T., Kato K., Hinou H., and Nishimura S.-I.* "Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide alpha-N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups”, Biochemistry, 49, 5929-5941 (2010).

69. Carvalho S., Sola-Penna M., Oliveira I., Pita S., Goncalves A., Neves B., Sousa F., Freire-de-Lima L., Kurogochi M., Hinou H., Nishimura S-I., Previato J., and Todeschini A.* "A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence", Glycobiology., 20, 1034-1045 (2010).

70. Arioka S., Sakagami S., Uematsu R., Yamaguchi H., Togame H., Takemoto H., Hinou H., Nishimura S.-I.* “Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase” Bioorg. Med. Chem., 18, 1633-1640 (2010).

71. Hinou H.,* Saito N., Ogawa M., Maeda T., Nishimura S.-I.* “Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide” Int. J. Mol. Sci. 10, 5285-5295 (2009).

72. Matsushita T., Sadamoto R., Oyabu N., Nakata H., Fumoto M., Fujitani N., Takegawa Y., Sakamoto T., Kurogochi M., Hinou H., Shimizu H., Ito T., Naruchi K., Togame H., Takemoto H., Kondo H., Nishimura S.-I.* “Functional Neoglycopeptides: Synthesis and Characterization of New Class MUC1 Glycoprotein Models Having Core 2-based O-Glycan and Complex-type N-Glycan Chains”, Biochemistry, 48, 11117-11133 (2009).

73. Ohyabu N., Hinou H., Matsushita T., Izumi R., Shimizu H., Kawamoto K., Numata Y., Togame H., Takemoto H., Kondo H., Nishimura S.-I.* "An Essential Epitope of Anti-MUC1 Monoclonal Antibody KL-6 Revealed by Focused Glycopeptide Library", J. Am. Chem. Soc., 131, 17102-17109 (2009).

74. Hachisu M., Hinou H., Takamichi M., Tsuda S., Koshida S., Nishimura S.-I.* “One-pot synthesis of cyclic antifreeze glycopeptides”, Chemical Communications, 13, 1641-1643 (2009).

75. Shimizu H., Yoshimura Y., Hinou H., Nishimura S.-I.* “A new glycosylation method part 3: study of microwave effects at low temperatures to control reaction pathways and reduce byproducts”, Tetrahedron, 64, 10091-10096 (2008).

76. Shimawaki K., Fujisawa Y., Sato F., Fujitani N., Kurogochi M., Hoshi H., Hinou H., and Nishimura S.-I.* “Highly efficient synthesis of versatile proteoglycan core structures from 1,6-anhydro-β-lactose as a key starting material”, Angew. Chem. Int. Ed. 46, 3074 -3079 (2007).

77. Shimaoka H., Kuramoto H., Furukawa J., Miura Y., Kurogochi M., Kita Y., Hinou H., Shinohara Y., and Nishimura S.-I.* “One-Pot Solid-Phase Glycoblotting and Probing by Transoximization for High-Throughput Glycomics and Glycoproteomics”, Chem. Eur. J., 13, 1664-1673 (2007).

78. Deguchi K.*, Ito H., Baba T., Hirabayashi A., Nakagawa H., Fumoto M., Hinou H., and Nishimura S.-I. “Structural analysis of O-glycopeptides employing negative- and positive-ion MSn spectra obtained by collision-induced and electron-capture dissociations in linear ion trap time-of-flight mass spectrometry”, Rapid Commun. Mass Spectrom., 21, 691-698 (2007).

79. Naruchi K., Hamamoto T., Kurogochi M., Hinou H., Shimizu H., Matsushita T.,  Fujitani N., Kondo H., Nishimura S.-I.* “Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and sphingoglycolipids”, J. Org. Chem., 71, 9609 - 9621 (2006).

80. X.-B. Li, Ogawa M., Monden T., Maeda T., Yamashita E., Naka M., Matsuda M., Hinou H., and Nishimura S.-I.* “Glycosidation Promoted by a Reusable Solid Superacid in Supercritical Carbon Dioxide”, Angew. Chem. Int. Ed., 45, 5652-5655 (2006).

81. Matsushita T., Hinou H., Fumoto M., Kurogochi M., Fujitani N., Shimizu H., Nishimura S.-I.* “Construction of Highly Glycosylated Mucin-Type Glycopeptides Based on Microwave-Assisted Solid Phase Synthesis and Enzymatic Modifications”, J. Org. Chem., 71, 3051 -3063, (2006).

82. Hinou H., Kurogochi M., Shimizu H., Nishimura S.-I.* “Characterization of Vibrio Cholerae Neuraminidase by a Novel Mechanism-Based Fluorescent Labeling Reagent” Biochemistry, 44, 11669-11675 (2005).

83. Fumoto M., Hinou H., Ohta T., Ito T., Yamada K., Takimoto A., Kondo H., Shimizu H.,  Inazu T., Nakahara Y., Nishimura S.-I.* “Combinatorial synthesis of MUC1 glycopeptides: Polymer blotting facilitates chemical and enzymatic synthesis of highly complicated mucin glycopeptides” J. Am. Chem. Soc., 127, 11804-11818 (2005).

84. Yoshimura Y., Shimizu H., Hinou H., Nishimura S.-I.* “A novel glycosylation concept; Microwave-assisted acetal-exchange type glycosylations from methyl glycosides donors”, Tetrahedron Lett., 46, 4701-4705 (2005).

85. Fumoto M., Hinou H., Matsushita T., Kurogochi M., Ohta T., Ito T., Yamada K., Takimoto A., Kondo H., Inazu T., and Nishimura S.-I.* “Molecular Transporter Between Polymer Platforms: Highly Efficient Chemoenzymatic Glycopeptide Synthesis by the Combined Use of Solid-Phase and Water-Soluble Polymer Supports”, Angew. Chem. Int. Ed., 44, 2534-2538 (2005).

86. Matsushita T., Hinou H., Kurogochi M., Shimizu H., and Nishimura S.-I.* “Rapid Microwave-Assisted Solid-Phase Glycopeptide Synthesis”, Org. Lett., 7, 877-880 (2005).

87. Nishimura S.-I.*, Niikura K., Kurogochi M., Matsushita T., Fumoto M., Hinou H., Kamitani R., Nakagawa H., Deguchi K., Miura N., Monde K., Kondo H. “High-Throughput Protein Glycomics: Combined Use of Chemoselective Glycoblotting and MALDI-TOF/TOF Mass Spectrometry” Angew. Chem. Int. Ed., 44, 91-96 (2005).

88. Matsuoka K.*, Ohtawa T., Hinou H., Koyama T., Esumi Y., Nishimura S.-I., Hatano K. and Terunuma D., “Synthesis of a useful anomeric thioacetate of an N-acetyllactosamine derivative and its application”, Tetrahedr Lett. 44, 3617-3620 (2003).

89. Kawamura K, Hinou H., Matsuo G, Nakata T.* “Efficient strategy for convergent synthesis of trans-fused polycyclic ethers based on an intramolecular SmI2-promoted cyclization of iodo ester” Tetrahedron Lett., 44, 5259-5261 (2003).

90. Hinou H., Sun X.-L., Ito Y.* “Systematic syntheses and inhibitory activities of bisubstrate-type inhibitors of sialyltransferases” J. Org. Chem., 68, 5602-5613, (2003).

91. Hinou H., Sun X.-L., Ito Y.* “Bisubstrate-type inhibitor of sialyltransferases” Tetrahedron Lett., 43, 9147-9150 (2002).

92. Matsuo G., Hinou H., Koshino H., Suenaga T., Nakata T.* "Efficient Convergent Synthesis of a trans-fused 6-6-6-6-membered tetracyclic ether ring system" Tetrahedron Lett., 41, 903-906 (2000).

93. Hinou H., Umino A., Matsuoka K., Terunuma D., Takahashi S., Esumi Y., Kuzuhara H.* “Synthesis of Amphiphilic Chitopentaose and Chitoheptaose Derivatives Using a Common Disaccharidic Synthon as the Chain Elongation Unit” Bull. Chem. Soc. Jpn., 73, 163-171 (2000).

94. Hinou H., Kurosawa H., Matsuoka K., Terunuma D., Kuzuhara H.* "Novel Synthesis of L-Iduronic Acid Using Trehalose as the Disaccharidic Starting Material" Tetrahedron Lett., 40, 1501-1504 (1999).

95. Umino A., Hinou H., Matsuoka K., Terunuma D., Takahashi S., Kuzuhara H.* "Efficient Conversion of a 1,6-Anhydro Chitobiose Derivative into the Corresponding tetradecyl b-Glycoside Derivative by Means of Paraticipation of a Neighboring Tetradecanamide Group" J. Carbohy. Chem., 17, 231-239 (1998).

96. Ogawa Y., Hinou H., Matsuoka K., Terunuma D., Kuzuhara H.* "Synthetic Conversion of Cellobiose into the Glycal-Type Monomers and Their Polymerization" Tetrahedron Lett., 39, 5789-5792 (1998).

97. Hinou H., Umino A., Matsuoka K., Terunuma D., Takahashi S., Esumi Y., Kuzuhara H.* "Synthesis of Amphiphilic Chitoheptaose Derivative" Tetrahedron Lett., 38, 8041-8044, (1997).

Review, Books etc.　　　　

　Book publication in Japan.

1. Hinou H. “DHB matrix with additives for direct MALDI mass spectrometry of carbohydrates and glycoconjugates” Trends in Glycoscience and Glycotechnology, 35, E19-E22 (2023). https://doi.org/10.4052/tigg.2214.1E 

2. Urakami S., Hinou H. “Development of O Antigen Rapid Typing by MALDI-TOF MS” J. Mass Spectrom. Soc. Jpn., 70, 237-240 (2022). https://doi.org/10.5702/massspec.S22-60 

3. Hinou H. “Glycan-Diversity Focused Glycopeptide Library”, Peptide Medicine -Screening, Stability, and Formulation technology-, Technical Information Institute, 74-82 (2017).

4. Hinou H. “Contraction and Functional Analysis of Glycopeptide Library Focused on Glycan Diversity”, Peptide News Letter Japan, 98, 2-5 (2015).

5. Hinou H. and Nishimura S.-I., “Enzymatic Synthesis II; Synthesis of Glycans using Glycosyltransferases”, Handbook of Glycans for Development of New Functions and Applications, NTS Publications, 394-396 (2015).

6. Amano M., Hinou H., Miyoshi R., Nishimura S.-I. “Potential usage for in vivo lectin screening in live animals utilized by cell surface mimetic glyco-nanoparticles, phosphorylcholine-coated quantum dots (PC-QDs)”, Methods in Molecular Biology, vol. 1200, 361-369 (2014).

7. Hinou H. and Nishimura S.-I., “Glycan Exchanging on Glycoprotain: Efficient synthesis of glycoprotein having single glycoform”, Review of Chemistry in 2014, Chemistry, 69, 74-75 (2014).

8. Hinou H. and Nishimura S.-I., “Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases”, Current Topics in Medicinal Chemistry, 9, 106-116 (2009).

9. Hinou H., Kurogochi M., and Nishimura S.-I., “Mechanism-Based Inhibitors to Probe Transitional States of Glycoside Hydrolases”, Methods in Enzymology, Academic Press, 415, 202-212 (2006).

10. Hinou H., Shimizu H., and Nishimura S.-I. “Automated Synthesizer for Enzymatic Oligosaccharide and Glycoconjugate Synthesis” AIST TODAY、Vol. 6、No.2、22-23 (2006).

11. Hinou H., Nishimura S.-I. “Development of Automated Oligosaccharide and Glycoconjugate Synthesizer” CMC Publishing, 3-12 (2005).

12. Hinou H. "Disaccharides as Starting Materials for the Synthesis of Valuable Compounds" Trends in Glycoscience and Glycotechnology, 12, 185-190 (2000).