I am with the Measurements & Instrumentation Group in the EE Dept. of IIT Madras. I have more than 9 years experience in medical device development as Chief Technologist of Healthcare Technology Innovation Centre, IIT Madras.
I focus on development of novel sensing systems and instruments for non-invasive and non-contact assessment of the human physiology, and have a special interest in vascular health. I strive towards developing innovative sensing technology and solutions, that not only work in our laboratory, but operate reliably in a clinical setting for enabling large scale validation studies that are necessary to drive clinical adoption of our research.
I apply system design and product development concepts in my research to ensure that our research prototypes are reliable and usable in real-world clinical settings. In addition to engineering research and technology development in the lab, I perform pre-clinical validation using physiological phantoms, ex-vivo studies using excised tissues and in-vitro studies in small and large animals in collaboration with animal study partners, to ensure that the technologies that we develop are safe and reliable. I perform clinical validation of our technologies in collaboration with multiples hospitals in India and abroad.
I primarily work on novel sensing technologies, intelligent signal processing and automated measurement algorithms, and system design for medical devices. I also have a keen interest in renewable energy from ocean waves.
Affordable, Accessible and Scalable technologies for creating large impact
Devices for early screening, diagnosis and chronic disease management
Cuff less blood pressure measurement
Non contact physiological sensing
Wearable sensors for health monitoring
Point of care diagnostics
ARTSENS : Image-free ultrasound for vascular ageing assessment
Magnetic Plethysmo Graph (MPG)
Accelerometer Plethysmo Graph (APG)
Local PWV sensing with piezo and pressure cuffs
Portable fluorescent imaging modules for quantitative immunoassay testing
Immunoassay based rapid testing devices and instrumentation
Instrumentation for digital histology and computational neuroanatomy of human brain
Renewable energy from ocean waves
Oscillating Water Column based wave power modules
1. J. Joseph, M. Sivaparakasam, J.K. Vasan, R.Kumaraswamy, R. Manoj, S. Chandrashekaran, N. Hari“Automated coverslipper for large format slides with switchable compatibility to handle multi format slides”, Indian Patent No. 546396, granted 30/07/2024
2. P. M. Nabeel, J. Joseph, M. Rahul, V. Raj Kiran, and M. Sivaprakasam, “A system for noninvasive calibration-free blood pressure (BP) measurement,” Indian Patent 541554, Jun. 12, 2024.
3. J. Joseph, V. Raj Kiran, P. M. Nabeel, and M. Sivaprakasam, “Method for tracing the motion of blood vessel boundaries,” Indian Patent 541123, Jun. 07, 2024.
4. J. Joseph, V. Raj Kiran, P. M. Nabeel, and M. Sivaprakasam, “Methods for identifying the boundaries of a blood vessel,” Indian Patent 532001, Apr. 05, 2024.
5. P. M. Nabeel, J. Joseph, M. Sivaprakasam, and V. Raj Kiran, “Multi-modal ultrasound probe for calibration-free cuff-less evaluation of blood pressure,” Indian Patent 525987, Mar. 14, 2024.
6. J. Joseph, C. Dinu, P. M. Nabeel, V. Raj Kiran, and M. Sivaprakasam, “Augmented multimodal flow mediated dilatation,” Indian Patent 521447, Mar. 07, 2024.
7. J. Joseph, P. M. Nabeel, M. I. Shah, V. Raj Kiran, and M. Sivaprakasam, “Image-free ultrasound for noninvasive assessment of early vascular health markers,” Indian Patent 512325, Feb. 19, 2024.
8. J. Joseph, P. M. Nabeel, M. I. Shah, V. Raj Kiran, and M. Sivaprakasam, “Image-free ultrasound for noninvasive assessment of early vascular health markers,” European Patent EP3884855, granted 24/01/2024
9. J. Joseph, M. Sivaprakasam, and P. M. Nabeel, “Method and system for cuff-less blood pressure (BP) measurement of a subject,” Indian Patent 462614, Oct. 27, 2023.
10.Lalit Mahajan, N. Mahajan, J. Joseph, J.K. Vasan, M. Sivaprakasam, “An improved analyser system,” Indian Patent. 479238, Dec 08, 2023.
11.P. M. Nabeel, J. Joseph, M. Sivaprakasam, and V. Raj Kiran, “Multi-modal ultrasound probe for calibration-free cuff-less evaluation of blood pressure,” United States Patent US11432792B2, Sep. 06, 2022.
12.P. M. Nabeel, J. Joseph, M. Sivaprakasam, and V. Raj Kiran, “Multi-modal accelerometer probe for calibration-free cuff-less evaluation of blood pressure,” United States Patent US11406349B2, Aug. 06, 2022.
13. J. Joseph, V. Jayashankar and B.George, “ A magnetic transducer system for non-invasive detection of blood flow pulse and evaluation of arterial compliance,” Indian Patent 381839, Nov 15, 2021
14. J. Joseph, M. Sivaprakasam, and P. M. Nabeel, “System for cuff-less blood pressure (BP) measurement of a subject,” European Patent EP3157416B1, Jul. 15, 2020.
15.J. Joseph, M. Sivaprakasam, and P. M. Nabeel, “Method and system for cuff-less blood pressure (BP) measurement of a subject,” United States Patent US10709424B2, Jul. 14, 2020.
16.J. Joseph, S. Seshadri, J. Venkataraman, M. Sivaprakasam, and A. Kumar Sahani, “Automated evaluation of arterial stiffness for a non-invasive screening,” Indian Patent 345719, Aug. 24, 2020.
17.Lalit Mahajan, N. Mahajan, J. Joseph, J.K. Vasan, M. Sivaprakasam “A fluorescence analyser system for rapid lateral flow assays,” Indian Patent No. 332279, granted 18/02/2020.
Journal Publications:
1. R. Manoj, V. R. Kiran, P. M. Nabeel, M. Sivaprakasam, and J. Joseph, “Carotid Pressure Wave Separation Analysis Using Multi-Rayleigh Flow Model,” IEEE Transactions on Biomedical Engineering, pp. 1–11, 2024, doi: 10.1109/TBME.2024.3515819.
2. K. M. van der Sluijs et al., “Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study,” Scandinavian Journal of Medicine & Science in Sports, vol. 34, no. 11, p. e14757, 2024, doi: 10.1111/sms.14757.
3. S. Zanelli et al., “Developing technologies to assess vascular ageing: a roadmap from VascAgeNet,” Physiol. Meas., Jun. 2024, doi: 10.1088/1361-6579/ad548e.
4. R. Verma et al., “Histological characterization and development of mesial surface sulci in the human brain at 13–15 gestational weeks through high-resolution histology,” Journal of Comparative Neurology, vol. 532, no. 4, p. e25612, 2024, doi: 10.1002/cne.25612.
5. K. M. Van Der Sluijs et al., “Association of objectively measured sedentary time with central and local arterial stiffness,” European Journal of Preventive Cardiology, vol. 31, no. Supplement_1, p. zwae175.401, Jun. 2024, doi: 10.1093/eurjpc/zwae175.401.
6. K. Pandurangan et al., “Systematic development of immunohistochemistry protocol for large cryosections-specific to non-perfused fetal brain,” Journal of Neuroscience Methods, vol. 405, p. 110085, May 2024, doi: 10.1016/j.jneumeth.2024.110085.
7. R. Manoj, P. M. Nabeel, V. Raj Kiran, M. Sivaprakasam, and J. Joseph, “Quantification of reflected wave magnitude and transit time using a multi-Rayleigh flow waveform model: A simplified approach to arterial wave separation analysis,” Biomedical Signal Processing and Control, vol. 93, p. 106129, Jul. 2024, doi: 10.1016/j.bspc.2024.106129.
8. K. M. van der Sluijs et al., “The Association Between Sedentary Behavior And Arterial Stiffness In Relation To Cardiovascular Health Status: 1226,” Medicine & Science in Sports & Exercise, vol. 55, no. 9S, p. 398, Sep. 2023, doi: 10.1249/01.mss.0000983536.26032.30.
9. P. Srivastava, P.M. Nabeel, K.V, Raj, M.Soneja,S.Chandran, J.Joseph, N.Wig, A.K. Jaryal,D.Thijssen, and K.K. Deepak, “Baroreflex sensitivity is impaired in survivors of mild COVID‐19 at 3–6 months of clinical recovery; association with carotid artery stiffness,” Physiological Reports, vol. 11, no. 21, p. e15845, Nov. 2023, doi: 10.14814/phy2.15845.
10. S. Natarajan, J. Joseph, B. Vinayagamurthy, and P. Estrela, “A Lateral Flow Assay for the Detection of Leptospira lipL32 Gene Using CRISPR Technology,” Sensors, vol. 23, no. 14, Art. no. 14, Jan. 2023, doi: 10.3390/s23146544.
11. S. Natarajan, J. Joseph, and D. M. F. Prazeres, “Graphene oxide coatings enhance fluorescence signals in a lateral flow immunoassay for the detection of UCH-L1, a marker for trauma brain injury,” Sensors and Actuators B: Chemical, vol. 393, p. 134336, Oct. 2023, doi: 10.1016/j.snb.2023.134336.
12. S. Natarajan and J. Joseph, “Signal enhancement using the europium nanoparticle over the organic dye in the quantitative lateral flow immunoassay development for the detection of the cTroponin I,” Science Talks, vol. 5, p. 100151, Mar. 2023, doi: 10.1016/j.sctalk.2023.100151.
13. K. M. van der Sluijs et al., “Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 324, no. 1, pp. H47–H56, Jan. 2023, doi: 10.1152/ajpheart.00335.2022.
14. S. Karthik et al., “Wide field block face imaging using deep ultraviolet induced autofluorescence of the human brain,” Journal of Neuroscience Methods, p. 109921, Jul. 2023, doi: 10.1016/j.jneumeth.2023.109921.
15. R. I. James et al., “A Standardized Protocol for the Safe Retrieval of Infectious Postmortem Human Brain for Studying Whole-Brain Pathology,” Am J Forensic Med Pathol, (in press), 2023.
16. S. Lyra et al., “Camera fusion for real-time temperature monitoring of neonates using deep learning,” Med Biol Eng Comput, vol. 60, no. 6, pp. 1787–1800, Jun. 2022, doi: 10.1007/s11517-022-02561-9.
17. K. V. Raj, P. M. Nabeel, M. Sivaprakasam, and J. Joseph, “Time-warping for robust automated arterial wall-recognition and tracking from single-scan-line ultrasound signals,” Ultrasonics, vol. 126, p. 106828, Dec. 2022, doi: 10.1016/j.ultras.2022.106828.
18. R. Manoj, K. V. Raj, P. M. Nabeel, M. Sivaprakasam, and J. Joseph, “Arterial pressure pulse wave separation analysis using a multi-Gaussian decomposition model,” Physiol Meas, vol. 43, no. 5, May 2022, doi: 10.1088/1361-6579/ac6e56.
19. P. M. Nabeel, K. V. Raj, and J. Joseph, “Image-free ultrasound for local and regional vascular stiffness assessment: the ARTSENS Plus,” Journal of Hypertension, vol. 38, no. 1, p. 10.1097/HJH.0000000000003181, Apr. 2022, doi: 10.1097/HJH.0000000000003181.
20. S. Natarajan, E. Saatçi, and J. Joseph, “Development and Evaluation of Europium-Based Quantitative Lateral Flow Immunoassay for the Chronic Kidney Disease Marker Cystatin-C,” J Fluoresc, vol. 32, no. 2, pp. 419–426, Mar. 2022, doi: 10.1007/s10895-021-02886-y.
21. K. V. Raj, P. M. Nabeel, and J. Joseph, “Image-Free Fast Ultrasound for Measurement of Local Pulse Wave Velocity: In Vitro Validation and In Vivo Feasibility,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 69, no. 7, pp. 2248–2256, Jul. 2022, doi: 10.1109/TUFFC.2022.3172265.
22. K. V. Raj, P. M. Nabeel, D. Chandran, M. Sivaprakasam, and J. Joseph, “High-frame-rate A-mode ultrasound for calibration-free cuffless carotid pressure: feasibility study using lower body negative pressure intervention,” Blood Pressure, pp. 1–12, Jan. 2022, doi: 10.1080/08037051.2021.2022453.
23. S. Natarajan and J. Joseph, “A novel time-resolved fluorescent lateral flow immunoassay for quantitative detection of the trauma brain injury biomarker-glial fibrillary acidic protein,” Sensors & Diagnostics, 2022, doi: 10.1039/D1SD00021G.
24. D. Dayanand, Irudhayanathan I, Kundu D, Manesh A, Abraham V, Abhilash KP, Chacko B, Moorthy M, Samuel P, Peerawaranun P, Mukaka M, Joseph J, Sivaprakasam M and Varghese GM, “Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention,” Int J Infect Dis, pp. S1201-9712(21)01255–8, Dec. 2021, doi: 10.1016/j.ijid.2021.12.356.
25. A. K. Sahani, D. Srivastava, M. Sivaprakasam, and J. Joseph, “A Machine Learning Pipeline for Measurement of Arterial Stiffness in A-Mode Ultrasound,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, pp. 1–1, 2021, doi: 10.1109/TUFFC.2021.3109117.
26. P. M. Nabeel, D. S. Chandran, P. Kaur, S. Thanikachalam, M. Sivaprakasam, and J. Joseph, “Association of incremental pulse wave velocity with cardiometabolic risk factors,” Sci Rep, vol. 11, no. 1, p. 15413, Dec. 2021, doi: 10.1038/s41598-021-94723-2.
27. Malik et al., “Single M-Line Is as Reliable as Multiple M-Line Ultrasound for Carotid Artery Screening,” Front. Physiol., vol. 12, p. 787083, Dec. 2021, doi: 10.3389/fphys.2021.787083.
28. L. P. Bheemavarapu, M. I. Shah, J. Joseph, and M. Sivaprakasam, “IQVision: An Image-Based Evaluation Tool for Quantitative Lateral Flow Immunoassay Kits,” Biosensors, vol. 11, no. 7, Art. no. 7, Jul. 2021, doi: 10.3390/bios11070211.
29. R. Arathy, P. M. Nabeel, V. V. Abhidev, M. Sivaprakasam, and J. Joseph, “An Accelerometric Sensor System With Integrated Hydrostatic Pressure Correction to Assess Carotid Arterial Stiffness,” IEEE Sensors Journal, vol. 21, no. 9, pp. 11163–11175, May 2021, doi: 10.1109/JSEN.2021.3059292.
30. S. Natarajan, J. Joseph, and D. M. F. Prazeres, “A Cellulose Paper-Based Fluorescent Lateral Flow Immunoassay for the Quantitative Detection of Cardiac Troponin I,” Biosensors, vol. 11, no. 2, Art. no. 2, Feb. 2021, doi: 10.3390/bios11020049.
31. S. Natarajan, M. C. DeRosa, M. I. Shah, and J. Joseph, “Development and Evaluation of a Quantitative Fluorescent Lateral Flow Immunoassay for Cystatin-C, a Renal Dysfunction Biomarker,” Sensors, vol. 21, no. 9, Art. no. 9, Jan. 2021, doi: 10.3390/s21093178
32. J. Joseph, P. M. Nabeel, S. R. Rao, R. Venkatachalam, M. I. Shah, and P. Kaur, “Assessment of Carotid Arterial Stiffness in Community Settings with ARTSENS®,” IEEE Journal of Translational Engineering in Health and Medicine, pp. 1–1, 2020, doi: 10.1109/JTEHM.2020.3042386. Impact factor: 1.754
33. Raj Kiran. V, J. Joseph, N. P. M, and M. Sivaprakasam, “Automated Measurement of Compression-Decompression in Arterial Diameter and Wall Thickness by Image-Free Ultrasound,” Computer Methods and Programs in Biomedicine, p. 105557, May 2020, doi: 10.1016/j.cmpb.2020.105557.
34. J. Joseph et al., “ARTSENS® Pen – portable easy-to-use device for carotid stiffness measurement: Technology validation and clinical-utility assessment,” Biomedical Physics & Engineering Express, Feb. 2020, doi: 10.1088/2057-1976/ab74ff. Impact Factor: 1.100
35. M. Paul, S. Karthik, J. Joseph et al., “Non-contact sensing of neonatal pulse rate using camera-based imaging: a clinical feasibility study,” Physiol. Meas., vol. 41, no. 2, p. 024001, Mar. 2020, doi: 10.1088/1361-6579/ab755c. Impact Factor:2.309
36. C. H. Antink et al., “Fast body part segmentation and tracking of neonatal video data using deep learning,” Med Biol Eng Comput, vol. 58, no. 12, pp. 3049–3061, Dec. 2020, doi: 10.1007/s11517-020-02251-4. Impact Facor:1.820
37. S. Natarajan, F. Su, J. Joseph, M. I. Shah and Y. Huang, “A paper microfluidics-based fluorescent lateral flow immunoassay for point-of-care diagnostics of non-communicable diseases,” Analyst (Royal Society of Chemistry), vol. 144, no. 21, pp.6291-6303, 2019. doi: 10.1039/C9AN01382B. Impact Factor: 4.019
38. P. Nabeel, V. Raj, J. Joseph, V. Abhidev, and M. Sivaprakasam, “Local pulse wave velocity: theory, methods, advancements, and clinical applications,” IEEE Reviews in Biomedical Engineering, Jul 29. doi: 10.1109/RBME.2019.2931587, 2019. Impact Factor: 2.880
39. R. Arathy, P. Nabeel, J. Joseph, and M. Sivaprakasam, “Accelerometric patch probe for cuffless blood pressure evaluation from carotid local pulse wave velocity: design, development, and in vivo experimental study,” Biomedical Physics & Engineering Express (IOP), vol. 5, no. 4, p. 045010, 2019. Impact Factor: 1.100
40. J. Joseph, P M. Nabeel, M. I. Shah, and M. Sivaprakasam, “Arterial compliance probe for cuffless evaluation of carotid pulse pressure,” PLoS One, vol. 13, no. 8, p. e0202480, Aug. 2018. Citation count: 2, Impact factor: 2.766
41. P M. Nabeel, J. Joseph, S. Karthik, M. Sivaprakasam and M. Chenniappan, "Bi-Modal Arterial Compliance Probe for Calibration-Free Cuffless Blood Pressure Estimation," in IEEE Transactions on Biomedical Engineering. doi: 10.1109/TBME.2018.2866332. Citation count: 2, Impact factor: 4.288
42. P M. Nabeel, S. Karthik, J. Joseph, and M. Sivaprakasam, “Arterial blood pressure estimation from local pulse wave velocity using dual-element photoplethysmograph
probe,” IEEE Transactions on Instrumentation and Measurement, vol. 67, no. 6, pp.
1399-1408, Feb. 2018. Citation count: 5, Impact factor: 2.794
43. A.S Anusha, J. Joy, S.P. Preejith, J. Joseph and M. Sivaprakasam, “Physiological signal-based work stress detection using unobtrusive sensors, Biomedical Physics & Engineering Express, vol. 4, no. 6, pp. 065001, 2018, IOP Publishing. Impact factor: NA
44. P M. Nabeel, J. Joseph, and M. Sivaprakasam, “Single-source PPG based local pulse wave velocity measurement: a potential cuffless blood pressure estimation technique,” Physiological Measurement, vol. 38, no. 12, pp. 2122-2140, Nov. 2017. Citation count: 14, Impact factor: 2.006
45. P M. Nabeel, J. Joseph and M. Sivaprakasam, “A magnetic plethysmograph probe for local pulse wave velocity measurement,” IEEE Transactions on Biomedical Circuits and Systems, vol. 11, no. 5, pp. 1065-1076, Oct. 2017. Citation count: 8, Impact factor: 3.500
46. Thendral Ganesh, J. Joseph, B. Bhikkaji, M. Sivaprakasam, “Sparse models and recursive computations for determining arterial dynamics,” J. Biomedical Signal Processing and Control, vol. 38, pp. 9 -21, September 2017. Impact factor: 2.783
47. A.K. Sahani, J. Joseph, R. Radhakrishnan, M. Sivaprakasam, S. Seshadri “Comparison of measurement of the augmentation index from ARTSENS and eTRACKING,” Biomedical Physics & Engineering Express, vol. 2, no. 1, pp. 015007, January 2016. Impact factor: NA
48. P.S. Rajesh, G. K. Verma, N. Raghavan, J. Joseph, M. Sivaprakasam, “Cataract surgery in mobile eye surgical unit: Safe and viable alternative,” Indian Journal of Ophthalmology, vol. 64, no. 11, pp.835-839, 2016. Citation count: 5, Impact factor: 0.961
49. J. Joseph, R. Radhakrishnan, S. Kusmakar, A. Thrivikraman, and M. Sivaprakasam, “Technical Validation of ARTSENS–An Image Free Device for Evaluation of Vascular Stiffness,” IEEE Journal of Translational Engineering in Health and Medicine, vol. 3, no. 1, pp. 1–13, Dec. 2015. Citation Count :17, Impact factor: 1.754
50. A. K. Sahani, J. Joseph, R. Radhakrishnan, and M. Sivaprakasam, “Automatic Measurement of End-Diastolic Arterial Lumen Diameter in ARTSENS,” ASME Journal of Medical Devices, vol. 9, no. 4, pp. 041002 - 11, 2015, doi:10.1115/1.4030873. Citation count: 12, Impact factor: 0.412
51. A.K. Sahani, M. Shah, J. Joseph, and M. Sivaprakasam, “Carotid and Jugular Classification in ARTSENS,” IEEE Journal of Biomedical and Health Informatics, vol. PP, no. 99, pp. 1–1, 2015, doi: 10.1109/JBHI.2015.2403283. Citation count: 8, Impact factor: 3.850
52. A. K. Sahani, M. I. Shah, R. Radhakrishnan, J. Joseph and M. Sivaprakasam, "An Imageless Ultrasound Device to Measure Local and Regional Arterial Stiffness," in IEEE Transactions on Biomedical Circuits and Systems, vol. 10, no. 1, pp. 200-208, Feb. 2016, doi: 10.1109/TBCAS.2015.2394468. Citation count: 6, Impact factor: 3.500
53. A. K. Sahani, J. Joseph, and M. Sivaprakasam, “Evaluation of the algorithm for automatic identification of the common carotid artery in ARTSENS,” Physiological Measurement, vol. 35, no. 7, pp. 1299–1317, Jul. 2014. Citation count: 12, Impact factor: 2.006
54. K. Mala, J. Joseph, V. Jayashankar, T. M. Muruganandam, S. Santhakumar, M. Ravindran, M. Takao, T. Setoguchi, K. Toyota, and S. Nagata, “A twin unidirectional impulse turbine topology for OWC based wave energy plants – Experimental validation and scaling,” Renewable Energy, vol. 36, no. 1, pp. 307–314, Jan. 2011. Citation count: 26, Impact factor: 4.900
55. J. Joseph and V. Jayashankar, “A Virtual Instrument for Automated Measurement of Arterial Compliance,” ASME Journal of Medical Devices, vol. 4, no. 4, p. 045004, 2010. Citation count: 33, Impact factor: 0.412
EE, 2008, pp. 2281–2284.
“The technical journey of the Indian wave energy plant”, edited by V. Jayashankar, published by National Institute of Ocean Technology (Co-author of 3 chapters)
