The jugular venous pulse (JVP) is a critical physiological indicator of right atrial hemodynamics, characterized by six distinct contour markers, three ascents (a, c, v) and three descents (x, x', y), that provide comprehensive insights into right heart function. JVP contour analysis facilitates the identification of cardiac anomalies, including tricuspid stenosis, cardiac tamponade, and pulmonary hypertension, which often evade early diagnosis due to the inherent limitations of current diagnostic methodologies. Addressing these limitations, our research focuses on developing methods and systems for the non-invasive acquisition of jugular venous pulse and quantification of its pulse contour markers for early detection of cardiac anomalies. The developed A-mode ultrasound system operates at an acquisition rate of 250 Hz, capturing high-fidelity JVP waveforms with a temporal resolution of 4 ms. 

Cardiovascular disease (CVD) is a leading global cause of death, highlighting the importance of early detection and prevention. Traditional vascular screening using markers like stiffness (β), compliance (AC), Ep, and PWV is limited by cost and complexity. Echocardiography, often performed after symptoms like angina, requires expensive equipment. CARDIOSENS estimates surrogate markers for cardiac output, LVEF, and AT/ET ratio using carotid and jugular vein pulses. LVEF is a vital predictor of heart failure mortality, while jugular vein pressure provides an approximation of central venous pressure.

Cardiovascular disease (CVD) remains one of the leading causes of mortality worldwide. To lower cardiac-related deaths, early recognition and prevention of CVD are crucial. There is an urgent demand for an affordable and user-friendly device capable of quantifying flow profiles and providing insights into vascular and cardiac markers. Pulse transit time (PTT), stroke volume(SV) and cardiac output(CO) calculations based on continuous bio-impedance measurements are essential for monitoring an individual's haemodynamics.

Frequent monitoring of vascular aging is becoming increasingly important, yet there is currently a lack of wearable technologies capable of tracking it through changes in vascular stiffness. To address this gap, we developed a wearable accelerometric device designed to detect variations in vascular stiffness by leveraging empirically derived markers from the amplitude features of acceleration plethysmogram (APG) signals captured at the carotid artery. Identifying amplitude-based markers from the APG that show significant changes in response to physiologically induced hemodynamic disturbances, and evaluating how the responses of these APG-derived markers compare in magnitude to established carotid stiffness metrics (β, Ep, and AC) measured with a clinically validated device. 

Introducing an arterial stiffness self-measurement device, a pioneering stride into home healthcare. This user-friendly, ergonomically crafted tool ensures effortless measurements, eliminating operator dependence. Transforming the home environment into a hub for cardiovascular assessment, it empowers individuals to monitor arterial stiffness comfortably. This innovative device heralds a new era in healthcare accessibility, providing a convenient solution for regular assessments without the need for external expertise. Embracing simplicity and independence, it paves the way for proactive cardiovascular well-being within the confines of one's home.

Developing an improved, calibration-free blood pressure measurement method that combines auscultatory, oscillometric techniques and pulse morphology analysis. By utilizing Korotkoff sounds and oscillogram data, this method accurately determines systolic and diastolic BP values, significantly minimizing error. Unlike traditional methods, it does not require specialized expertise, making it accessible. This approach enhances measurement accuracy while maintaining ease of use, addressing the limitations of conventional auscultation and oscillometric techniques in BP monitoring solutions.

A non-invasive endothelial reactivity assessment (ERA) device has been developed to evaluate the response of arterial material properties and stiffness to shear stimuli. Utilizing cuff-based pressure sensors and A-mode ultrasound, it continuously measures brachial artery pressure and diameter. Results show high repeatability (ICC > 0.9) and strong correlation with standard flow-mediated dilation (R² > 0.8), validated on over 50 healthy individuals. This innovative device offers a novel approach to quantifying endothelial reactivity through local stiffness responses during reactive hyperemia.