Publications
Bauminger, H., Chandran, S. K., Zaidan, H., Akirav, I., & Gaisler-Salomon, I. (2025). Chemogenetic attenuation of PFC pyramidal neurons restores recognition memory deficits following adolescent NMDA receptor blockade. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 111359.
Asraf, K., Zaidan, H., Natoor, B., & Gaisler-Salomon, I. (2023). Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression. Translational Psychiatry, 13(1), 248. https://doi.org/10.1038/s41398-023-02534-y
Zaidan, H., Wnuk, A., Aderka, I. M., Kajta, M., & Gaisler-Salomon, I. (2023). Pre-reproductive stress in adolescent female rats alters maternal care and DNA methylation patterns across generations. Stress, 26(1). https://doi.org/10.1080/10253890.2023.2201325
Bauminger, H., & Gaisler-Salomon, I. (2022). Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia. International Journal of Molecular Sciences, 23(15), 8617. https://doi.org/10.3390/ijms23158617
Bauminger, H., Zaidan, H., Akirav, I., & Gaisler-Salomon, I. (2022). Anandamide hydrolysis inhibition reverses the long-term behavioral and gene expression alterations induced by MK-801 in male rats: Differential CB1 and CB2 receptor-mediated effects. Schizophrenia Bulletin, 48(4), 795-803. https://doi.org/10.1093/schbul/sbab153
Zaidan, H., Galiani, D. & Gaisler-Salomon, I. Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms. Transl Psychiatry 11, 113 (2021). https://doi.org/10.1038/s41398-021-01220-1
Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I. Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction. Schizophr Bull. 2019 Jan 1;45(1):127-137. doi: 10.1093/schbul/sby011. PubMed PMID: 29471549; PubMed Central PMCID: PMC6293228.
Zaidan H, Ramaswami G, Barak M, Li JB, Gaisler-Salomon I. Pre-reproductive stress and fluoxetine treatment in rats affect offspring A-to-I RNA editing, gene expression and social behavior. Environ Epigenet. 2018 Apr;4(2):dvy021. doi: 10.1093/eep/dvy021. eCollection 2018 Apr. PubMed PMID: 30109132; PubMed Central PMCID: PMC6084559.
Zaidan H, Ramaswami G, Golumbic Y, Sher N, Malik A, Barak M, Galiani D, Dekel N, Li J, Gaisler-Salomon I. A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations. BMC Genomics. 2018-1-; 19(1):-. doi: 10.1186/s12864-017-4409-8.
Mingote S, Chuhma N, Kalmbach A, Thomsen GM, Wang Y, Mihali A, Sferrazza C, Zucker-Scharff I, Siena AC, Welch MG, Lizardi-Ortiz J, Sulzer D, Moore H, Gaisler-Salomon I, Rayport S. Dopamine neuron dependent behaviors mediated by glutamate cotransmission. Elife. 2017 Jul 13;6. doi: 10.7554/eLife.27566. PubMed PMID: 28703706; PubMed Central PMCID: PMC5599237.
Braun K, Bock J, Wainstock T, Matas E, Gaisler-Salomon I, Fegert J, Ziegenhain U, Segal M. Experience-induced transgenerational (re-)programming of neuronal structure and functions: Impact of stress prior and during pregnancy. Neurosci Biobehav Rev. 2020 Oct;117:281-296. doi: 10.1016/j.neubiorev.2017.05.021. Epub 2017 May 29. Review. PubMed PMID: 28571876.
Lander SS, Linder-Shacham D, Gaisler-Salomon I. Differential effects of social isolation in adolescent and adult mice on behavior and cortical gene expression. Behav Brain Res. 2017 Jan 1;316:245-254. doi: 10.1016/j.bbr.2016.09.005. Epub 2016 Sep 13. PubMed PMID: 27618762.
Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun. 2016 Sep 6;7:12743. doi: 10.1038/ncomms12743. PubMed PMID: 27597321; PubMed Central PMCID: PMC5025847.
Bock J, Poeschel J, Schindler J, Börner F, Shachar-Dadon A, Ferdman N, Gaisler-Salomon I, Leshem M, Braun K, Poeggel G. Transgenerational sex-specific impact of preconception stress on the development of dendritic spines and dendritic length in the medial prefrontal cortex. Brain Struct Funct. 2016 Mar;221(2):855-63. doi: 10.1007/s00429-014-0940-4. Epub 2014 Nov 14. PubMed PMID: 25395153.
Mingote S, Masson J, Gellman C, Thomsen GM, Lin CS, Merker RJ, Gaisler-Salomon I, Wang Y, Ernst R, Hen R, Rayport S. Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice. Front Syst Neurosci. 2015;9:165. doi: 10.3389/fnsys.2015.00165. eCollection 2015. PubMed PMID: 26778975; PubMed Central PMCID: PMC4705219.
Zaidan H, Gaisler-Salomon I. Prereproductive stress in adolescent female rats affects behavior and corticosterone levels in second-generation offspring. Psychoneuroendocrinology. 2015 Aug;58:120-9. doi: 10.1016/j.psyneuen.2015.04.013. Epub 2015 Apr 24. PubMed PMID: 25973567.
Brande-Eilat N, Golumbic YN, Zaidan H, Gaisler-Salomon I. Acquisition of conditioned fear is followed by region-specific changes in RNA editing of glutamate receptors. Stress. 2015;18(3):309-18. doi: 10.3109/10253890.2015.1073254. PubMed PMID: 26383032.
Hazan L, Gaisler-Salomon I. Glutaminase1 heterozygous mice show enhanced trace fear conditioning and Arc/Arg3.1 expression in hippocampus and cingulate cortex. Eur Neuropsychopharmacol. 2014 Dec;24(12):1916-24. doi: 10.1016/j.euroneuro.2014.10.003. Epub 2014 Oct 18. PubMed PMID: 25453483.
Gaisler-Salomon I, Kravitz E, Feiler Y, Safran M, Biegon A, Amariglio N, Rechavi G. Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease. Neurobiol Aging. 2014 Aug;35(8):1785-91. doi: 10.1016/j.neurobiolaging.2014.02.018. Epub 2014 Mar 1. PubMed PMID: 24679603.
Kravitz E, Gaisler-Salomon I, Biegon A. Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. PLoS One. 2013;8(11):e81244. doi: 10.1371/journal.pone.0081244. eCollection 2013. PubMed PMID: 24312282; PubMed Central PMCID: PMC3842934.
Zaidan H, Leshem M, Gaisler-Salomon I. Prereproductive stress to female rats alters corticotropin releasing factor type 1 expression in ova and behavior and brain corticotropin releasing factor type 1 expression in offspring. Biol Psychiatry. 2013 Nov 1;74(9):680-7. doi: 10.1016/j.biopsych.2013.04.014. Epub 2013 May 29. PubMed PMID: 23726318.
Mihali A, Subramani S, Kaunitz G, Rayport S, Gaisler-Salomon I. Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery. Expert Rev Neurother. 2012 Jul;12(7):785-99. doi: 10.1586/ern.12.60. Review. PubMed PMID: 22853787; PubMed Central PMCID: PMC3509194.
Gaisler-Salomon I, Wang Y, Chuhma N, Zhang H, Golumbic YN, Mihali A, Arancio O, Sibille E, Rayport S. Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation. Hippocampus. 2012 May;22(5):1027-39. doi: 10.1002/hipo.22014. Epub 2012 Mar 19. PubMed PMID: 22431402; PubMed Central PMCID: PMC3531559.
Gaisler-Salomon I, Schobel SA, Small SA, Rayport S. How high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophrenia. Schizophr Bull. 2009 Nov;35(6):1037-44. doi: 10.1093/schbul/sbp114. Epub 2009 Oct 14. PubMed PMID: 19828591; PubMed Central PMCID: PMC2762634.
Gaisler-Salomon I, Miller GM, Chuhma N, Lee S, Zhang H, Ghoddoussi F, Lewandowski N, Fairhurst S, Wang Y, Conjard-Duplany A, Masson J, Balsam P, Hen R, Arancio O, Galloway MP, Moore HM, Small SA, Rayport S. Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology. 2009 Sep;34(10):2305-22. doi: 10.1038/npp.2009.58. Epub 2009 Jun 10. PubMed PMID: 19516252; PubMed Central PMCID: PMC2811085.