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Research
Research
Young Hee Kim
Research Professor
* E-Mail : kyh1230@dau.ac.kr
2000.03.~2004.02 Han Nam University (B.S.)
2004.03.~2006.02 Soonchunhyang University (M.S.)
2006.03.~2009.02. Soonchunhyang University(Ph.D.)
2009.09.~2011.08 Soonchunhyang University (Research Professor)
2016.09.~Present Dong-A University (Research Professor)
<Research>
Pathological Schwann cells
Biomarker of Neuropathy
Publications
22. Kim YH, Yoon BA, Jo YR, Nam SH, Kim NH, Kim KH, Kim JK, Choi BO, Park HT. Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease. Eur J Neurol. 2023 Jun;30(6):1745-1754.
21. Han SH, Kim YH, Park SJ, Cho JG, Shin YK, Hong YB, Yun J, Han JY, Park HT, Park JI. COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20. J Neurochem. 2023 Jun;165(5):660-681.
20. Jo YR, Oh Y, Kim YH, Shin YK, Kim HR, Go H, Shin J, Park HJ, Koh H, Kim JK, Shin JE, Lee KE, Park HT. Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination. Cell Mol Life Sci. 2023 Jan 9;80(1):34.
19. Kim YH, Jang SY, Shin YK, Jo YR, Yoon BA, Nam SH, Choi BO, Shin HY, Kim SW, Kim SH, Kim JK, Park HT. Serum CXCL13 reflects local B-cell mediated inflammatory demyelinating peripheral neuropathy. Sci Rep. 2019 Nov 11;9(1):16535.
18. Park HT, Kim YH, Lee KE, Kim JK. Behind the pathology of macrophage-associated demyelination in inflammatory neuropathies: demyelinating Schwann cells. Cell Mol Life Sci. 2020 Jul;77(13):2497-2506.
17. Kim YH, Kim YH, Shin YK, Jo YR, Park DK, Song MY, Yoon BA, Nam SH, Kim JH, Choi BO, Shin HY, Kim SW, Kim SH, Hong YB, Kim JK, Park HT. p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies. Ann Clin Transl Neurol. 2019 Jul;6(7):1292-1301.
16. Jyoti MA, Nam KW, Jang WS, Kim YH, Kim SK, Lee BE, Song HY. Antimycobacterial activity of methanolic plant extract of Artemisia capillaris containing ursolic acid and hydroquinone against Mycobacterium tuberculosis. J Infect Chemother. 2016 Apr;22(4):200-8.
15. Kim YH, Kang JS. Micro-computed tomography evaluation and pathological analyses of female rats with collagen-induced arthritis. J Vet Sci. 2015;16(2):165-71.
14. Kim YH, Kwak KA, Gil HW, Song HY, Hong SY. Indoxyl sulfate promotes apoptosis in cultured osteoblast cells. BMC Pharmacol Toxicol. 2013 Dec 1;14:60.
13. Song HY, Kim YH, Seok SJ, Gil HW, Hong SY. In vitro cytotoxic effect of glyphosate mixture containing surfactants. J Korean Med Sci. 2012 Jul;27(7):711-5.
12. Kim YH, Kwak KA, Kang JS. Expression of neighbor of Punc E11 in hepatocarcinogenesis induced by diethylnitrosamine. Oncol Rep. 2014 Sep;32(3):1043-9.
11. Kim YH, Kwak KA, Kim TS, Seok JH, Roh HS, Lee JK, Jeong J, Meang EH, Hong JS, Lee YS, Kang JS. Retinopathy Induced by Zinc Oxide Nanoparticles in Rats Assessed by Micro-computed Tomography and Histopathology. Toxicol Res. 2015 Jun;31(2):157-63.
10: Choi JS, Jou SS, Oh MH, Kim YH, Park MJ, Gil HW, Song HY, Hong SY. The dose of cyclophosphamide for treating paraquat-induced rat lung injury. Korean J Intern Med. 2013 Jul;28(4):420-7.
9. Song HY, Kim YH, Seok SJ, Gil HW, Yang JO, Lee EY, Hong SY. Cellular toxicity of surfactants used as herbicide additives. J Korean Med Sci. 2012 Jan;27(1):3-9.
8. Kim YH, Kang JS. Effect of methotrexate on collagen-induced arthritis assessed by micro-computed tomography and histopathological examination in female rats. Biomol Ther (Seoul). 2015 Mar;23(2):195-200.
7. Nguyen TH, Kim YH, Song HY, Lee BT. Nano Ag loaded PVA nano-fibrous mats for skin applications. J Biomed Mater Res B Appl Biomater. 2011 Feb;96(2):225-33.
6. Kim YH, Hong JR, Gil HW, Song HY, Hong SY. Mixtures of glyphosate and surfactant TN20 accelerate cell death via mitochondrial damage-induced apoptosis and necrosis. Toxicol In Vitro. 2013 Feb;27(1):191-7.
5. Kim YH, Kang JS. Expression of glypican-3 in mouse embryo stem cells and its derived hepatic lineage cells treated with diethylnitrosamine in vitro. Asian Pac J Cancer Prev. 2013;14(11):6341-5.
4. Kim YH, Jyoti MA, Youn MH, Youn HS, Seo HS, Lee BT, Song HY. In vitro and in vivo evaluation of a macro porous β-TCP granule-shaped bone substitute fabricated by the fibrous monolithic process. Biomed Mater. 2010 Jun;5(3):35007.
3. Kim YH, Anirban JM, Song HY, Seo HS, Lee BT. In vitro and in vivo evaluations of 3D porous TCP-coated and non-coated alumina scaffolds. J Biomater
Appl. 2011 Feb;25(6):539-58.
2. Choi JS, Kwak KA, Park MJ, Kim YH, Gil HW, Song HY, Hong SY. Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat. Med Sci Monit. 2013 Jan 9;19:28-33.
1. Seok S, Kim YH, Gil HW, Song HY, Hong SY. The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for
death and organ failure in acute paraquat intoxication. J Korean Med Sci. 2012 Sep;27(9):993-8.
So Young Jang
Research Professor
* E-Mail : Soung3e@dau.ac.kr
2005.03.~2009.02 Pukyoung National University (B.S.)
2010.03.~2012.02 Dong-A University (M.S.)
2012.03.~2016.02. Dong-A University (Ph.D.)
2016.02.~Present Dong-A University (Research Professor)
<Research>
Role of Autophagy in Myelinating or Demyelinating Schwann cell
Publications
18. Jeon H*, Jang SY*, Kwak G*, Yi YW*, You MH*, Park NY*, Jo JH, Yang JW, Jang HJ, Jeong WY, Moon SK, Doo HM, Nahm M, Kim D, Chang JW, Choi BO, Hong YB. TGFβ4 alleviates the phenotype of Charcot-Marie-Tooth disease type 1A. Brain. 2023 May awad147. doi:10.1093/brain/awad147
17. Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 Jan;35(1):e21225
16. Kim YH, Jang SY, Shin YK, Jo YR, Yoon BA, Nam SH, Choi BO, Shin HY, Kim SW, Kim SH, Kim JK, Park HT. Serum CXCL13 reflects local B-cell mediated inflammatory demyelinating peripheral neuropathy. Sci Rep. 2019 Nov 11;9(1):16535.
15. Jang SY, Yoon BA, Shin YK, Yun SH, Jo YR, Choi YY, Ahn M, Shin T, Park JI, Kim JK, Park HT. Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination. Glia. 2017 Nov; 65(11):1848-1862.
14. Shin YK, Jang SY, Yun SH, Choi YY, Yoon BA, Jo YR, Park SY, Pak MG, Park JI, Park HT. Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair. Glia. 2017 Nov; 65(11):1794-1808.
13. Park SY, Jang SY, Shin YK, Yoon BA, Lee HJ, Park HT. Grb2-associated binder-1 is required for extrafusal and intrafusal muscle fiber development. Neuroreport. 2017 Jul 5;28(10):604-609.
12. Park SY, Jang SY, Shin YK, Jung DK, Yoon BA, Kim JK, Jo YR, Lee HJ, Park HT. The Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation. Exp Neurobiol. 2017 Jun;26(3):141-150.
11. Jang SY, Shin YK, Park SY, Park JY, Lee HJ, Yoo YH, Kim JK, Park HT. Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. Glia. 2016 May; 64(5):730-742.
10. Jang SY, Shin YK, Park SY, Park JY, Rha SH, Kim JK, Lee HJ, Park HT. Autophagy is involved in the reduction of myelinating Schwann cell cytoplasm during myelin maturation of the peripheral nerve. PLoS One. 2015. Jan; 12;10(1):e0116624.
9. Shin YK, Jang SY, Park SY, Park JY, Kim JK, Kim JP, Suh DJ, Lee HJ, Park HT. Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination. The Journal of Neuroscience. 2014. May; 28;34(22):7657-7662
8. Park JY, Jang SY, Shin YK, Suh DJ, Park HT. Calcium-dependent proteasome activation is required for axonal neurofilament degradation. Neural Regen Res. 2013 Dec 25;8(36):3401-9.
7. Shin YK, Jang SY, Park JY, Park SY, Lee HJ, Suh DJ, Park HT. The Neuregulin-Rac-MKK7 pathway regulates antagonistic c-jun/Krox20 expression in Schwann cell dedifferentiation. Glia. 2013. Jun; 61(6):892-904.
6. Park JY, Jang SY, Shin YK, Koh H, Suh DJ, Shinji T, Araki T, Park HT. Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration. Neuroscience. 2013 May 15;238:258-69.
5. Jang SY, Shin YK, Lee HY, Park JY, Suh DJ, Kim JK, Bae YS, Park HT. Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nerves. Glia. 2012. Oct; 60(10):1619-1628
4. Jung J, Cai W, Jang SY, Shin YK, Suh DJ, Kim JK, Park HT. Transient lysosomal activation is essential for p75 nerve growth factor receptor expression in myelinated Schwann cells during Wallerian degeneration.. Anat Cell Biol. 2011 Mar;44(1):41-9
3. Jung J, Cai W, Lee HK, Pellegatta M, Shin YK, Jang SY, Suh DJ, Wrabetz L, Feltri ML, Park HT. Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. The Journal of Neuroscience. 2011. Feb; 9;31(6):2009-2015.
2. Shin YK, Jang SY, Lee HK, Jung J, Suh DJ, Seo SY, Park HT. Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy. Glia. 2010. Dec; 58(16):1961-1976.
1. Jang SY, Shin YK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT. Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor. Neuroscience Letters. 2010. Nov; 12;485(1):37-42
Hye Ran Kim
Postdoctoral fellow
* E-Mail : khr99@dau.ac.kr
2014.03.~2019.02 Dong-A University (B.S.)
2019.03.~2021.02 Dong-A University (M.S.)
2021.03.~2024.02. Dong-A University (Ph.D.)
2024.09.~Present Dong-A University (postdoctoral fellow)
<Research>
The role of autophagy in peripheral sensory neuron development and regeneration
Pathogenesis of peripheral neurodegenerative diseases associated with SARM1-dependent axonal degeneration
Publications
3. Kim HR, Lee HJ, Joen Y, Jang SY, Shin YK, Yun JH, Park HJ, Koh H, Lee KE, Shin JE, Park HT. Targeting SARM1 improves autophagic stress-induced axonal neuropathy. Autophagy. 2024 Jan;20(1):29-44.
2. Jo YR, Oh Y, Kim YH, Shin YK, Kim HR, Go H, Shin J, Park HJ, Koh H, Kim JK, Shin JE, Lee KE, Park HT. Adaptive autophagy reprogramming in Schwann cells during peripheraldemyelination. Cell Mol Life Sci. 2023 Jan 9;80(1):34.
1. Jo YR*, Kim HR*, Jang SY*, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 Jan;35(1):e21225.
Da Jeong Jeong
Ph.D.course
* E-Mail : 0526ma@naver.com
2016.03.~2020.02 Dong-Eui Univertisy (B.S.)
2020.03.~2022.02 Dong-A University (M.S.)
2023.02.~2023.08 Dong-A University (Researcher)
2023.09.~Present Dong-A University (Ph.D.course)
<Research>
Role of autophagy in Schwann cell myelination and demyelination
Publications
Yun HJ, Jeoung DJ, Jin S, Park JH, Lee EW, Lee HT, Choi YH, Kim BW, Kwon HJ. Induction of Cell Cycle Arrest, Apoptosis, and Reducing the Expression of MCM Proteins in Human Lung Carcinoma A549 Cells by Cedrol, Isolated from Juniperus chinensis. J Microbiol Biotechnol. 2022 Jul 28;32(7):918-926.
Jin Young Lee
Researcher
* E-Mail : ljy1025@dau.ac.kr
2018.03.~2023.02 Dong-Eui Univertisy (B.S.)
2022.12.~2023.02 Dong-A University (Intern)
2023.03.~Present Dong-A University (Researcher)
<Research>
The role of autophagy in peripheral sensory neuron development and regeneration
Suyeon Jo
Researcher
* E-Mail : whtndus@dau.ac.kr
2019.03.~2023.02. Silla University (B.S.)
2023.03.~2025.02 Dong-A University (Assistant)
2025.03.~Present Dong-A University (Researcher)
Ju-Hye Han
Researcher
* E-Mail : hihi912@dau.ac.kr
2010.03-2014.02 SoonChunHyang university (B.S.)
2014.03-2016.02 SoonChunHyang university (M.S.)
2016.01-2016.12 SoonChunHyang university (Researcher)
2017.01-2020.12 Catholic Kwandong University (Researcher)
2023.07-Present Dong-A University (Researcher)
Staff
Staff
Na Eun Baek
Administration
* E-Mail : aaa5573@dau.ac.kr
2011.03.~2016.02 Dong-A Univertisy (B.S.)
2018.12.~Present (Administration)
Jushin Kim
Assistant
* E-Mail : juzzy825@dau.ac.kr
2017.03.~2021.02 동아대학교 음악학과 (B.S.)
2021.03.~Present 동아대학교 일반대학원 음악학과 (Administration)
2025.03.~Present Dong-A University (Assistant)
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