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Current Research Projects
Current Research Projects
Membrane Mimetic Models for Drug Delivery
Development of nanoscale structures as biophysical models of the cell membrane. Applications include study of
Drug Delivery; insights into mechanism and dynamics of small molecule and drug delivery vehicle mediated drug permeation/endosome escape
Membrane Proteins; including transmembrane proteins. We are assessing lipid and protein diffusion over such structures using Fluorescence Lifetime Correlation Spectroscopy and fluorescence recovery after photobleaching
Lipid Protein Interactions; Aggregation and Network formation at the membrane.
Luminescent Probes and Particles for Imaging and Sensing within the Cellular environment.
We work on the design and synthesis of environmentally sensitive charge-transfer probes, both inorganic and organic as probes for sensing within the cellular environment. Highly specific organelle, nucleic acid or protein targeting is achieved using peptides and oligonucleotides and the performance of these materials is explored in a range of mammalian cell lines. Target in-cell analytes include molecular oxygen, Reactive oxygen species, nucleic acids, metals, protein signals and membrane viscosity. Such parameters are key markers of cellular metabolism and health and the capacity to monitor these parameters in real time has wide-ranging application across medical sciences, biology and pharmacy.
Biocompatible Nanostructured Interfaces for Cell Capture and Surface Enhanced Raman Spectroscopy
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