Singh's MBHI Lab - Projects

Ongoing Projects:

Exploring the efficacy of promising RAR-Gama agonists in pre-clinical (in-vitro and in-vivo) heterotopic ossification models for therapeutic implications in Fibrodysplasia ossificans progressive (FOP) (2024-27; Funded by ICMR, Govt. of India)
Immunotherapeutic role of Vitamin A (Retinoic acid) in the in vitro model of tuberculosis.(2022-24; Funded by SERB-DST)
Identification of the molecular mechanism of mechano transduction pathways that act upstream of Hippo Pathway for treatment of breast cancer.(2021-24; Funded by ICMR, Govt. of India)
Design, synthesis and biological evaluation of novel lead compounds for treatment of Fibrodysplasia Ossificans Progressiva.(FOP) (2020-2024; Funded by ICMR, Govt. of India)

Completed Projects:

Pharmacophore modelling to design novel inhibitors of MCL-1 as targeted therapy of human cancer.(2019-2022; Funded by DHR, Govt. of India)
Cloning and functional characterisation of Helicoverpa inducible hevein-like protein from chickpea (2013-16; Funded by SERB, DST)
Identification and characterization of genes involved in defense against Spodopteralitura from Maize (Zea mays) (2013-16; Funded by SERB, DST)
The impact of lifestyle change during adolescence on lifestyle chronic Diseases (2015-16; Funded by UGC/DU)
dsRNA-conjugated nanoparticles for gene silencing in Aedesaegypti(Raman Postdoctoral Fellowship; 2016-17; Funded by UGC)
Design and development of novel inhibitors of AKRIC1 as potential lead candidates in treatment of breast, cervical & endometrial cancer (2016-19; Funded by DHR, Govt. of India)
A comparative analysis of Jasmonoyl-L-iso levcine turn-over in the QTL mapping population of Nicotiana attenuata during Manduca sexta infestation(2019-19; Funded by Max Planck Society, Germany)

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