Research in my laboratory includes synthetic inorganic and organic chemistry, biological chemistry to address important metal-mediated processes relevant to medicinal problems and fundamental inorganic chemistry problems. Novel molecular design, strategies are being used to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to help unsolved problems with broad implications to our society. Different research projects are pursued to attract students with different research interests and to provide them with a good training for their future chemistry careers. 

• Development of 2-bis(quinolin-2-ylmethylene)hydrazine based half-sandwich ruthenium(II) arene complexes with high cytotoxicity in castration-resistant prostate cancer cell, Khan, T. A.; Yadav, A.; Kumar, V.; Sharma, A. K. Eur. J. Inorg. Chem., 2025, e202400851.. 

• Evaluation of Anti-Alzheimer’s Potential of Azo-Stilbene-Thioflavin-T derived Multifunctional Molecules: Synthesis, Metal and A Species Binding and Cholinesterase Activity, Rana, M.; Terpstra, K.; Gutierrez, C.; Xu, K.; Arya, H.; Bhatt, T. K.; Mirica, L. M.; Sharma, A. K. Chem. Eur. J., 2024, e202402748.

• Bis-quinoline ruthenium(II) arene complexes with submicromolar cytotoxicity in castration-resistant prostate cancer cells, Khan, T. A.; Bhar, K.; Bhatt, S.; Kumar, V.; Kumari R.; Sharma, A. K. Chem. Commun., 2024, 60, 1579..

• Azo-Stilbene and Pyridine-Amine Hybrid Multifunctional Molecules to Target Metal Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s disease Rana, M.; Cho, H.J.; Arya, H.; Bhatt, T. K.; Bhar, K.; Mirica, L. M.; Sharma, A. K. Inorg. Chem. 2022, 61, 10294-10309. 

• Development, Evaluation and Effect of Anionic Co-ligand on the Biological Activity of Benzothiazole Derived Copper(II) Complexes, Jain, S.; Bhar, K.; Bandyopadhyaya, S.; Singh, V. K.; Mandal, C. C.; Tapryal, S.; Sharma, A. K. J. Inorg. Biochem., 2020, 210, 111174.