Sea slug enzymes

The marine gastropod Tritonia deomedea is an invertebrate model organism. We obtain tissue samples from Professor James Murray (Department of Biological Sciences, CSUEB) who studies the neurobiology and behavior of this sea slug.

Glutathione-S-transferase (GST)

GST is a detoxification enzyme. The marine slug Tritonia diomedea can feed upon a toxic soft coral called Ptilosarcus gurneyi. To elucidate the molecular mechanisms within marine food chains graduate students were purifying and characterizing the GST enzyme from the slug's digestive gland. Sam Cooney, Miguel Garcia and Shuang Huang completed their master theses on this project:

Cooney, Sam. "Purification of glutathione-S-transferase from digestive glands of Tritonia diomedea" (2022). https://scholarworks.calstate.edu/concern/theses/9z903577b?locale=en

Garcia, Miguel. "Large scale purification of glutathione-S-transferase from the marine gastropod Tritonia diomedea." (2021). https://scholarworks.calstate.edu/downloads/wm117v22s

Huang, Shuang Cui. "Characterization of Glutathione-S-transferase from Toxin-Resistant Gastropod Tritonia diomedea." (2016). https://scholarworks.calstate.edu/downloads/2r36tz28b

Acetylcholinesterase (AChE)

AChE terminates cholinergic signaling by cleaving the neurotransmitter acetylcholine into choline and acetate. The characterization of AChE is important, since Tritonia diomedea is an invertebrate model for studying the neuronal basis of behavior. Several graduate students were involved in this project. Their master theses are listed here:

Coreas Cruz, Jahiro. "Characterization of acetylcholinesterase within Tritonea diomedea" (2023). https://scholarworks.calstate.edu/concern/theses/cz30q095s

Sahebi, Showhib. "Identifying acetylcholinesterase oligomerization states in Tritonia diomedea tissues." (2020). https://scholarworks.calstate.edu/downloads/3484zk05g

Makani, Leena Priya. "Method Development to Characterize Acetlycholinesterase Isoforms of Tritonia tetraquetra." (2018). http://csueastbay-dspace.calstate.edu/bitstream/handle/10211.3/207686/Leena.Priya.MakaniThesis.pdf?sequence=1

Ureno, Eric. "Purification and Characterization of Acetylcholinesterase from Tritonia tetraquetra Hemolymph." (2015). http://csueastbay-dspace.calstate.edu/bitstream/handle/10211.3/158634/Eric.UrenoThesis.pdf?sequence=1

Tran, Vu. "Enzyme Kinetic Characterization of Acetylcholinesterase from Tritonia Diomedea." (2012).

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