Content Objective: XXX
Language Objective: XXX
Syllabus Details:
D1.2.13 - Initiation of transcription at the promoter - "Consider transcription factors that bind to the promoter as an example. However, students are not required to name other types."
D1.2.14 - Non-coding sequences in DNA do not code for polypeptides - "Limit examples to regulators of gene expression, introns, telomeres, and genes for rRNAs and tRNAs in eukaryotes."
D1.2.15 - Post-transcriptional modification in eukaryotic cells - "Include removal of introns and splicing together of exons to form mature mRNA and also the addition of 5' caps and 3' polyA tails to stabilize mRNA transcripts."
D1.2.16 - Alternative splicing of exons to produce variants of a protein from a single gene - "Use alternative splicing of transcripts of the troponin T gene in foetal and adult heart muscle as an example."
B2.2.2 - Advantage of the separation of the nucleus and cytoplasm into separate compartments - "Limit to separation of the activities of gene transcription and translation—post-transcriptional modification of mRNA can happen before the mRNA meets ribosomes in the cytoplasm. In prokaryotes, this is not possible—mRNA may immediately meet ribosomes."
B2.2.7 - Structure and function of free ribosomes and of the rough endoplasmic reticulum - "Contrast the synthesis by free ribosomes of proteins for retention in the cell with synthesis by membrane-bound ribosomes on the rough endoplasmic reticulum of proteins for transport within the cell and secretion."
B2.2.8 - Structure and function of the Golgi apparatus - "Limit to the roles of the Golgi apparatus in processing and secretion of protein."
B2.2.9 - Structure and function of vesicles in cells - "Include the role of clathrin in the formation of vesicles."
D1.2.18 - Modification of polypeptides into their functional state - "Students should appreciate that many polypeptides must be modified before they can function. The examples chosen should include the two-stage modification of pre-proinsulin to insulin."
D1.2.19 - Recycling of amino acids by proteasomes - "Limit to the understanding that sustaining a functional proteome requires constant protein breakdown and synthesis.”
Activity 1
Activity 2
Activity 3
A. Strengthen Your Skills
B. Expand Your Knowledge