A. Content Objective: The skin and mucous membranes form primary defense again pathogens and blood clotting helps maintain this barrier by fixing cuts using a complex series of chemical reactions.
B. Language Objective: The cascade reaction, clotting factors, fibrinogen and fibrin all work together to form a blood clot.
C. Syllabus Details:
Clotting
C3.2.2—Skin and mucous membranes as a primary defence - "The skin acts as both a physical and chemical barrier to pathogens. Students are not required to draw or label diagrams of skin."
C3.2.3—Sealing of cuts in skin by blood clotting - "Include release of clotting factors from platelets and the subsequent cascade pathway that results in rapid conversion of fibrinogen to fibrin by thrombin and trapping of erythrocytes to form a clot. No further details are required."
Resources
Clotting
Video:
Innate Immunity - Watch until 3:00 (i)
Immune System Primary defences (i)
Reading:
Bioninjia - Blood Clotting (ii-iv)
Immunity (i-iv) - focus on 1,9 and 10
Activity 1
Immune System - The Amoeba Sisters
Focus on the big picture and create a set of notes outlining the three lines of defence
Activity 2
Blood Clotting Skits
Objective - Create a skit that shows blood clotting using all the keywords below.
Guidelines:
You must use at least 5 different props in the skit...you can work with in groups of up to 4 people.
You need a narrator and the following keywords must be used.
You will then film the skit and put it in this folder.
We will watch them all and hopefully laugh!
Keywords:
Blood vessels
Platelets
Fibrin strands
Coagulation Cascade
Vasoconstriction
prothrombin (enzyme)
thrombin (enzyme)
fibrinogen
fibrin
A. Strengthen Your Skills
B. Expand Your Knowledge
Here is the full description of blood clotting - Good for medical school
Muscosal Immunity Overview - Interesting, but I'm a biology teacher