Publications

Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow. 

Takuya Koike, Kentaro Fujii, Kohei Kometani, Noah S Butler, Kenji Funakoshi, Shinya Yari, Junichi Kikuta, Masaru Ishii, Tomohiro Kurosaki, Wataru Ise

The Journal of experimental medicine 220(2) 2023年2月6日

BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors. 

Kota Itahashi, Takuma Irie, Junichiro Yuda, Shogo Kumagai, Tokiyoshi Tanegashima, Yi-Tzu Lin, Sho Watanabe, Yasushi Goto, Jun Suzuki, Keiju Aokage, Masahiro Tsuboi, Yosuke Minami, Genichiro Ishii, Yuichiro Ohe, Wataru Ise, Tomohiro Kurosaki, Yutaka Suzuki, Shohei Koyama, Hiroyoshi Nishikawa

Science immunology 7(76) eabk0957 2022年10月14日  

Batf-mediated epigenetic control of effector CD8+ T cell differentiation. 

Hsiao-Wei Tsao, James Kaminski, Makoto Kurachi, R Anthony Barnitz, Michael A DiIorio, Martin W LaFleur, Wataru Ise, Tomohiro Kurosaki, E John Wherry, W Nicholas Haining, Nir Yosef

Science immunology 7(68) eabi4919 2022年2月18日  

Silencing and activating anergic B cells. 

Shinya Tanaka, Wataru Ise, Yoshihiro Baba, Tomohiro Kurosaki

Immunological reviews 2021年12月14日  

Plasma cell generation during T-cell-dependent immune responses. 

Wataru Ise, Tomohiro Kurosaki

International immunology 33(12) 797-801 2021年11月25日  

Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. 

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki

Nature immunology 21(12) 1611-1612 2020年12月  

Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4. 

Kentaro Fujii, Shinya Tanaka, Takanori Hasegawa, Masashi Narazaki, Atsushi Kumanogoh, Haruhiko Koseki, Tomohiro Kurosaki, Wataru Ise

International immunology 32(10) 683-690 2020年9月30日  

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant. 

Michelle Sue Jann Lee, Yayoi Natsume-Kitatani, Burcu Temizoz, Yukiko Fujita, Aki Konishi, Kyoko Matsuda, Yoshikatsu Igari, Toshihiro Tsukui, Kouji Kobiyama, Etsushi Kuroda, Motoyasu Onishi, Thomas Marichal, Wataru Ise, Takeshi Inoue, Tomohiro Kurosaki, Kenji Mizuguchi, Shizuo Akira, Ken J Ishii, Cevayir Coban

European journal of immunology 49(9) 1433-1440 2019年9月

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. 

Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America 115(33) 8418-8423 2018年8月14日 

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. 

Etsushi Kuroda, Koji Ozasa, Burcu Temizoz, Keiichi Ohata, Christine X Koo, Tomohiro Kanuma, Takato Kusakabe, Shingo Kobari, Masanori Horie, Yasuo Morimoto, Saeko Nakajima, Kenji Kabashima, Steven F Ziegler, Yoichiro Iwakura, Wataru Ise, Tomohiro Kurosaki, Takahiro Nagatake, Jun Kunisawa, Naoki Takemura, Satoshi Uematsu, Masayuki Hayashi, Taiki Aoshi, Kouji Kobiyama, Cevayir Coban, Ken J Ishii

Immunity 45(6) 1299-1310 2016年12月20日  

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. 

Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita

Nature communications 7 12596-12596 2016年9月1日 

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. 

Yuhsuke Ohmi, Wataru Ise, Akira Harazono, Daisuke Takakura, Hidehiro Fukuyama, Yoshihiro Baba, Masashi Narazaki, Hirofumi Shoda, Nobunori Takahashi, Yuki Ohkawa, Shuting Ji, Fumihiro Sugiyama, Keishi Fujio, Atsushi Kumanogoh, Kazuhiko Yamamoto, Nana Kawasaki, Tomohiro Kurosaki, Yoshimasa Takahashi, Koichi Furukawa

Nature communications 7 11205-11205 2016年4月5日 

Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen. 

Motoyasu Onishi, Koji Ozasa, Kouji Kobiyama, Keiichi Ohata, Mitsutaka Kitano, Keiichi Taniguchi, Tomoyuki Homma, Masanori Kobayashi, Akihiko Sato, Yuko Katakai, Yasuhiro Yasutomi, Edward Wijaya, Yoshinobu Igarashi, Noriyuki Nakatsu, Wataru Ise, Takeshi Inoue, Hiroshi Yamada, Alexis Vandenbon, Daron M Standley, Tomohiro Kurosaki, Cevayir Coban, Taiki Aoshi, Etsushi Kuroda, Ken J Ishii

Journal of immunology (Baltimore, Md. : 1950) 194(6) 2673-82 2015年3月15日  

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4. 

James Badger Wing, Wataru Ise, Tomohiro Kurosaki, Shimon Sakaguchi

Immunity 41(6) 1013-25 2014年12月18日 

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. 

Brian T Edelson, Wumesh KC, Richard Juang, Masako Kohyama, Loralyn A Benoit, Paul A Klekotka, Clara Moon, Jörn C Albring, Wataru Ise, Drew G Michael, Deepta Bhattacharya, Thaddeus S Stappenbeck, Michael J Holtzman, Sun-Sang J Sung, Theresa L Murphy, Kai Hildner, Kenneth M Murphy

The Journal of experimental medicine 207(4) 823-36 2010年4月12日

The AP-1 transcription factor Batf controls T(H)17 differentiation. 

Barbara U Schraml, Kai Hildner, Wataru Ise, Wan-Ling Lee, Whitney A-E Smith, Ben Solomon, Gurmukh Sahota, Julia Sim, Ryuta Mukasa, Saso Cemerski, Robin D Hatton, Gary D Stormo, Casey T Weaver, John H Russell, Theresa L Murphy, Kenneth M Murphy

Nature 460(7253) 405-9 2009年7月16日

Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation. 

Wataru Ise, Kentaro Nakamura, Nobuko Shimizu, Hirofumi Goto, Kenichiro Fujimoto, Shuichi Kaminogawa, Satoshi Hachimura

Journal of immunology (Baltimore, Md. : 1950) 175(2) 829-38 2005年7月15日  

Ca2+ signaling down-regulates TGF-beta1 gene expression in CD4+ T cells. 

Masako Kohyama, Yasuhito Yasogi, Naoko Nakano, Wataru Ise, Shuichi Kaminogawa, Nobumichi Hozumi

Biochemical and biophysical research communications 327(2) 494-9 2005年2月11日

Dendritic Cells from Spleen, Mesenteric Lymph Node and Peyer's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4(+) T Cells in a Dose-Dependent Manner. 

Masanobu Hibi, Satoshi Hachimura, Wataru Ise, Ayuko Sato, Tadashi Yoshida, Tsuyoshi Takayama, Kastumi Sasaki, Takashi Senga, Shuichi Hashizume, Mamoru Totsuka, Shuichi Kaminogawa

Cytotechnology 43(1-3) 49-55 2003年11月 

Identification of the genes specifically expressed in orally tolerized T cells. 

Takayasu Gotoh, Wataru Ise, Atsuko Nonaka, Shuichi Hamaguchi, Satoshi Hachimura, Shuichi Kaminogawa

Cytotechnology 43(1-3) 73-80 2003年11月

Interleukin 12 and CD86 Regulate Th1 and Th2 Development Induced by a Range of Antigen Doses Presented by Peyer's Patch and Spleen Cells. 

Tadashi Yoshida, Satoshi Hachimura, Mina Ishimori, Wataru Ise, Mamoru Totsuka, Akio Ametani, Shuichi Kaminogawa

Cytotechnology 43(1-3) 81-8 2003年11月

Antigen presentation by Peyer's patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells. 

Tadashi Yoshida, Satoshi Hachimura, Mina Ishimori, Fumitaka Kinugasa, Wataru Ise, Mamoru Totsuka, Akio Ametani, Shuichi Kaminogawa

Bioscience, biotechnology, and biochemistry 66(5) 963-9 2002年5月