publications

1) HJ Kim*, HG Ryu*, M Kang, N Lee, HJ Kim, D Lee, C Chung, S Kim, KH Lee, W Kim, JS Byun, KT Kim, DY Kim (2024). SYNCRIP promotes cell cycle progression and lung tumorigenesis by modulating AURKB translation. Cancer Commun (Lond). doi: 10.1002/cac2.12634. Online ahead of print. [*Co-first author]

2) JU Park, JH Jo, S Kim, CE Redon, MI Aladjem, Y Seo, SJ Jang, SM Jang (2024). RepID as a potential biomarker and therapeutic target for lung neuroendocrine tumor. Sci Rep. 14: 27487. 

3) J Na, HG Ryu, Haeun Park, Hyeonwoo Park, E Lee, Y Nam, H Kim, SM Jang, DY Kim, S Kim (2024). FoxO1 Alleviates the Mitochondrial ROS Levels Induced by α‑Synuclein Preformed Fibrils in BV‑2 Microglial Cells. Inflammation. doi: 10.1007/s10753-024-02119-x. Online ahead of print.

4) E Lee*, Hyeonwoo Park*, S Kim (2024). Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases. Mol. Cells. 47(8): 100089. [*Co-first author]

5) SH Kweon*, HG Ryu*, SH Kwon, Hyeonwoo Park, S Lee, NS Kim, SX Ma, HJ Jee, S Kim#, HS Ko# (2024). Gba1 E326K renders motor and non-motor symptoms with pathological α-synuclein, tau and glial activation. Brain. 147 (12), 4072-4083. [*Co-first author, #Co-corresponding author]

6) X Mao, H Gu, D Kim, Y Kimura, N Wang, E Xu, R Kumbhar, X Ming, H Wang, C Chen, S Zhang, C Jia, Y Liu, H Bian, SS Karuppagounder, F Akkentli, Q Chen, L Jia, H Hwang, SH Lee, X Ke, M Chang, A Li, J Yang, C Rastegar, M Sriparna, P Ge, S Brahmachari, S Kim, S Zhang, Y Shimoda, M Saar, H Liu, SH Kweon, M Ying, CJ Workman, DAA Vaignali, UC Muller, C Liu, HS Ko, VL Dawson, TM Dawson (2024). Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein. Nat Commun. 15(1): 4663

7) H Koh, W Kang, YY Mao, J Park, S Kim, SH Hong, JH Lee (2024). Employment of diverse in vitro systems for analyzing multiple aspects of disease, hereditary hemorrhagic telangiectasia (HHT). Cell & Bioscience 14(1): 65

8) Y Nam*, J Na*, SX Ma, Haeun Park, Hyeonwoo Park, E Lee, H Kim, SM Jang, HS Ko, S Kim (2024). DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency. Genes & Genomics. 46 (5): 519-529. [*Co-first author]

1) JH Jo, JU Park, YM Kim, SM Ok, DK Kim, DH Jung, HJ Kim, HA Seong, HJ Cho, J Nah, S Kim, H Fu, CE Redon, MI Aladjem, SM Jang (2023). RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter. Cell Commun Signal. 21(1):219.

1) SH Kuo, I Tasset, MM Cheng, A Diaz, MK Pan, OJ Lieberman, SJ Hutten, RN Alcalay, S Kim, P Ximénez-Embún, L Fan, D Kim, HS Ko, T Yacoubian, E Kanter, L Liu, G Tang, J Muñoz, SP Sardi, A Li, L Gan, AM Cuervo, D Sulzer (2022). Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy. Sci Adv. 8(6):eabm6393.

2) Y Kim, H Kim, D Kim, D Jung, HJ Cho, S Kim, J Nah, SM Jang (2022). Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction. Biochemical and Biophysical Research Communications, 637, 341-347.

3) J Park, D Kim, J Kim, J Jo, Y Kim, D Jung, H Kim, S Ok, HJ Cho, S Kim, CE Redon, MI Aladjem, SM Jang (2022). The differentially expressed gene signatures of the cullin 3-RING ubiquitin ligases in neuroendocrine cancer. Biochemical and Biophysical Research Communications, 636, 71-78.

4) S Lee*, HG Ryu*, SH Kweon, H Kim, Hyeonwoo Park, KH Lee, SM Jang, CH Na, S Kim#, HS Ko# (2022). c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation. Cells, 11, 3972. [*Co-first author, #Co-corresponding author]

1) BA Seo, D Kim, H Hwang, MS Kim, SX Ma, SH Kwon, SH Kweon, H Wang, JM Yoo, S Choi, SH Kwon, SU Kang, TI Kam, K Kim, SS Karuppagounder, BG Kang, S Lee, H Park, S Kim, W Yan, YS Li, SH Kuo, J Redding-Ochoa, O Pletnikova, JC Troncoso, G Lee, X Mao, VL Dawson, TM Dawson, HS Ko (2021). TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Neuron. 3758-3774. e11

2) SH Kwon*, S Kim*, AY Park*, S Lee, CG Gadhe, BA Seo, JS Park, S Jo, Y Oh, SH Kweon, SX Ma, WR Kim, M Kim, H Kim, JE Kim, S Lee, J Lee, HS Ko (2021). Novel, Selective c-Abl inhibitor, Compound 5 prevents neurodegeneration in Parkinson’s disease. J Med Chem. 64(20):15091-15110. [*Co-first author]

1) X Mao, H Gu, D Kim, Y Kimura, N Wang, E Xu, H Wang, C Chen, S Zhang, C Jia, Y Liu, H Bian, SS Karuppagounder, L Jia, X Ke, M Chang, A Li, J Yang, C Rastegar, M Sriparna, P Ge, S Brahmachari, S Kim, S Zhang, Y Shimoda, M Saar, CJ Workman, DAA Vaignali, UC Muller, C Liu, HS Ko, VL Dawson, TM Dawson (2021). Aplp1 and the Aplp1-Lag3 complex facilitates transmission of pathologic α-synuclein. bioRxiv 2021.05.01.442157; doi: https://doi.org/10.1101/2021.05.01.442157

2) SX Ma, BA Seo, D Kim, Y Xiong, SH Kwon, S Brahmachari, S Kim, TI Kam, RS Nirujogi, SH Kwon, VL Dawson, TM Dawson, A Pandey, CH Na and HS Ko (2021). Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in alpha-synuclein-based mouse models of Parkinson’s disease. J. Proteome Res. 20(7), 3428-3443

3) S Kim*, SH Kwon*, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, WR Kim, M Kook, CA Foss, C Shen, H Lee, S Kulkarni, PJ Pasricha, G Lee, MG Pomper, VL Dawson, TM Dawson and HS Ko (2019). Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease. Neuron. 103(4):627-641. [*Co-first author].

4) S Brahmachari*, S Lee*, S Kim*, C Yuan, SS Karuppagounder, P Ge, R Shi, EJ Kim, A Liu, D Kim, S Quintin, H Jiang, M Kumar, SP Yun, TI Kam, X Mao, Y Lee, DA Swing, L Tessarollo, HS Ko, VL Dawson and TM Dawson (2019). Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain. 142(8):2380-2401. [*Co-first author].

5) J Lee, S Lee, YJ Ryu, D Lee, S Kim, JY Seo, E Oh, SH Paek, SU Kim, CM Ha, SY Choi and KT Kim (2019). Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment. Glia. 67(9):1667-1679.

6) S Ham, H Kim, S Hwang, H Kang, SP Yun, S Kim, D Kim, HS Kwon, YS Lee, M Cho, HM Shin, H Choi, KY Chung, HS Ko, GH Lee, Y Lee (2019). Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 42(6):480-494.

7) Y Suh, SJ Noh, S Lee, BK Suh, SB Lee, J Choi, J Jeong, S Kim, SK Park (2019). Dopamine D1 Receptor (D1R) Expression is Controlled by a Transcriptional Repressor Complex Containing DISC1. Mol Neurobiol. 56(10):6725-6735.

8) HG Rye*, S Kim*, S Lee, E Lee, HJ Kim, DY Kim and KT Kim (2019). HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of Vaccinia-related kinase 2. J Neurochem. 149(3):413-426 [*Co-first author].

9) YH Jeong, JH Choi, S Kim, KT Kim (2018). Vaccinia-related kinase 2 modulates role of dysbindin by regulating protein stability. J Neurochem. 147(5):609-625.

10) D Kim, JM Yoo, H Hwang, J Lee, S Lee, SP Yun, M Park, MJ Lee, S Choi, SH Kwon, S Lee, SH Kwon, S Kim, YJ Park, M Kinoshita, YH Lee, S Shin, SR Paik, SJ Lee, S Lee, BH Hong, HS Ko (2018). Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease. Nat Nanotechnol. 13(9):812–818.

11) SP Yun, TI Kam, N Panicker, S Kim, Y Oh, JS Park, SH Kwon, YJ Park, SS Karuppagounder, H Park, S Kim, N Oh, NA Kim, S Lee, S Brahmachari, X Mao, JH Lee, M Kumar, D An, SU Kang, Y Lee, KC Lee, DH Na, D Kim, SH Lee, VV Roschke, SA Liddelow, Z Mari, BA Barres, VL Dawson, S Lee, TM Dawson, HS Ko (2018). Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease. Nat Med. 24(7):931-938.

12) S Lee*, S Kim*, YJ Park, SP Yun, SH Kwon, D Kim, DY Kim, JS Shin, DJ Cho, GY Lee, HS Ju, HJ Yun, JH Park, WR Kim, EA Jung, S Lee, HS Ko (2018). The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model. Hum Mol Genet. 27(13):2344-2356 [*Co-first author].

13) S Kim*, SP Yun*, S Lee, GE Umanah, VVR Bandaru, X Yin, P Rhee, SS Karuppagounder, SH Kwon, H Lee, X Mao, D Kim, A Pandey, G Lee, VL Dawson, TM Dawson and HS Ko (2018). GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proc. Natl. Acad. Sci. U. S. A. 115(4):798-803. [*Co-first author].

14) SP Yun*, D Kim*, S Kim*, SM Kim, SS Karuppagounder, SH Kwon, S Lee, TI Kam, S Lee, S Ham, JH Park, VL Dawson, TM Dawson, Y Lee, HS Ko (2018). α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. Mol. Neurodegener. 13(1):1. [*Co-first author].

15) E Lee, HG Ryu, S Kim, D Lee, YH Jeong and KT Kim (2016). Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity. Sci. Rep. 6:29097.

16) H Song, W Kim, JH Choi, SH Kim, D Lee, CH Park, S Kim, DY Kim and KT Kim (2016). Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation. Sci. Rep. 6:28634.

17) SH Kim, HN Lyu, YS Kim, YH Jeon, W Kim, S Kim, JK Lim, HW Lee, NI Baek, KY Choi, J Lee and KT Kim (2015). Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier- to-autointegration factor phosphorylation. J. Pharmacol. Exp. Ther. 352(1):175-84.

18) S Choi, D Kim, TI Kam, S Yun, S Kim, H Park, H Hwang, O Pletnikova, JC Troncoso, VL Dawson, TM Dawson and HS Ko (2015). Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS One. 10(12):e0143854.

19) S Kim*, D Lee*, J Lee, H Song, HJ Kim and KT Kim (2015). VRK2 controls the stability of the eukaryotic chaperonin TRiC/CCT by inhibiting the deubiquitinating enzyme USP25. Mol. Cell. Biol 35(10):1754-62. [*Co-first author].

20) S Kim and KT Kim (2014). Therapeutic approaches for inhibition of protein aggregation in Huntington’s disease. Exp Neurobiol. 23(1):36-44.

21) S Kim, DY Park, D Lee, W Kim, YH Jeong, J Lee, SK Chung, H Ha, BH Choi and KT Kim (2014). Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. Mol Cell Biol. 34(4):643-52.

22) J Im*, S Kim*, YH Jeong, W Kim, D Lee, WS Lee, YT Chang, KT Kim and SK Chung (2013). Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington’s disease. MedChemComm. 4:310-316. [*Co-first author], Cover story.

23) W Kim, G Chakraborty, S Kim, J Shin, CH Park, MW Jeong, N Bharatham, HS Yoon, and KT Kim (2012). MacroH2A1 suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 287:5278-89.

24) KC Woo, TD Kim, KH Lee, DY Kim, S Kim, HR Lee, HJ Kang, SJ Chung, S Senju, Y Nishimura, KT Kim (2011). Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs. FASEB J. 25:2757-69.

25) CH Park, BH Choi, MW Jeong, S Kim, W Kim, YS Song, KT Kim (2010). Protein kinase C {delta} regulates vaccinia related kinase 1 in DNA damage induced apoptosis. Mol Biol Cell 22:1398-408.