Dr, Intekhab Alam, Research associate

ixa57@case.edu

Research Showcase 2015, Case Western Reserve University, Cleveland, Ohio. (Best Poster Award)

July 2003-November 2005: Department of Biotechnology, Government of India, Studentship for Master’s Degree.

September 2007-September 2009: Korea University Studentship for Ph.D.

Junior Research Fellowship form Indian Council of Medical Research (ICMR), government of India in year 2005

Junior Research Fellowship form Council of Scientific, Industrial Research Fellowship (CSIR), government of India, 2005

List of Publications:

  • Zhang J, Gurusaran M, Fujiwara Y, Zhang K, Echbarthi M, Vorontsov E, Guo R, Pendlebury D, Alam I, Livera G, Emmanuelle M, Wang P, Nandakumar J, Davies O, Shibuya HThe BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nat Commun 11, 2055 (2020). https://doi.org/10.1038/s41467-020-15954-x

  • Lee, J.H*., Park, B.S*., Alam, I*., Han, K.R., Biering, S.B, Kim, S.J., Choi, J., Seok, J.H., Chung, M.S, Kim, H.M., Hwang, S., and Kim, K.H. (2018). Insight into the interaction between RNA polymerase and VPg for Murine Norovirus Replication. Frontiers in Microbiology 9, 1466-1478. (Co-first author)

  • Ahmad, M.F*., Alam, I*., Huff, S.E*., Pink, J., Flanagan, S.A., Shewach, D., Misko, T.A., Oleinick, N.L., Harte, W.E., Viswanathan, R., et al. (2017). Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A 114, 8241-8246. (Co-first author)

  • Ahmad, M.F., Huff, S.E., Pink, J., Alam, I., Zhang, A., Perry, K., Harris, M.E., Misko, T., Porwal, S.K., Oleinick, N.L., et al. (2015). Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem 58, 9498-9509.

  • Alam, I., Lee, J.H., Cho, K.J., Han, K.R., Yang, J.M., Chung, M.S., and Kim, K.H. (2012). Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin. Virology 426, 143-151.

  • Lee, J.H*., Alam, I*., Han, K.R., Cho, S., Shin, S., Kang, S., Yang, J.M., and Kim, K.H. (2011). Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase. J Gen Virol 92, 1607-1616. (Co-first author)

  • Geronikaki, A., Eleftheriou, P., Vicini, P., Alam, I., Dixit, A., and Saxena, A.K. (2008a). 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action. J Med Chem 51, 5221-5228.

  • Geronikaki, A.A., Lagunin, A.A., Hadjipavlou-Litina, D.I., Eleftheriou, P.T., Filimonov, D.A., Poroikov, V.V., Alam, I., and Saxena, A.K. (2008b). Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition. J Med Chem 51, 1601-1609.

  • Saxena, A.K., Alam, I., Dixit, A., and Saxena, M. (2008). Internet resources in GPCR modelling. SAR QSAR Environ Res 19, 11-25.