Publications

Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin Y-H, Hsieh M-H, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. 

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

Cell, 2023, 186 (9) 1968-84

Yin K, Patten D, Gough S, de Barros Gonçalves S, Chan A, Olan I, Cassidy L, Poblocka M, Zhu H, Lun A, Schuijs M, Young A, Martinez-Jimenez C, Halim T, Shetty S, Narita M*, Hoare M*. *Co-corresponding authors

Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance. 

Genes and Development, 2022, 36(9-10):533-549. 

Ng SWK, Rouhani FJ, Brunner SF, Brzozowska N, Aitken SJ, Yang M, Abascal F, Moore L, Nikitopoulou E, Chappell L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders A, Williams N, Coorens THH, Teague J, Raine K, Butler AP, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies SE, Stratton MR, Martincorena I, Rahbari R, Frezza C, Hoare M*, Campbell PJ*. *Co-corresponding authors

Convergent somatic mutations in effectors of insulin signalling in chronic liver disease. 

Nature, 2021, 598 (7881) 473-478. 

Gonçalves S, Yin K, Ito Y, Chan, A, Olan I, Gough S, Cassidy L, Serrao E, Smith S, Young A, Narita M, Hoare M. 

COX2 regulates senescence secretome composition and senescence surveillance through PGE2. 

Cell Reports, 2021, 34(11):108860.

Brunner SF, Roberts ND, Wylie LA, Moore L, Aitken SJ, Davies SE, Sanders MA, Ellis P, Alder C, Hooks Y, Abascal F, Stratton MR, Martincorena I, Hoare M*, Campbell PJ*. *Co-corresponding authors

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. 

Nature, 2019, 574 (7779) 538.  

Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M. 

NOTCH1 mediates a switch between two distinct secretomes during senescence. 

Nature Cell Biology, 2016, 18(9) 979-992.