Biography

Dr. Matt Hoare is Assistant Professor of Hepatology at the University of Cambridge, based at the Early Cancer Institute and hepatologist at Addenbrooke’s Hospital in Cambridge. He leads the East of England service for hepatocellular carcinoma (HCC), seeing patients from across the region and contributing to numerous observational and interventional clinical trials in HCC.

His research interests centre around the diseased liver microenvironment and why this drives carcinogenesis. He completed his Wellcome Trust-funded PhD at the Department of Medicine in Cambridge, investigating the presence and functionality of senescent immune cells in the liver microenvironment. During CRUK Clinician Scientist fellowships at the CRUK Cambridge Institute, he investigated mechanisms of senescence secretome control and their roles in long-term tumorigenesis in the liver microenvironment.

After being appointed Assistant Professor in 2020, he has defined the genomic consequences of chronic liver disease, allowing us to understand the burden of DNA damage and the clonal dynamics of cirrhotic nodules in CLD. This work has developed an understanding of the cancerisation field effect that exists in CLD. More recently a CRUK Programme Foundation Award will see him start a new lab in the Early Cancer Institute.