SW480, CHTN06, SB051, and SB521 Cell lines are the current cell lines used as the experimental model
The NeuroBioImpact Lab is committed to advancing undergraduate research in cancer biology, providing students with opportunities to investigate the molecular and cellular mechanisms driving cancer progression, therapy response, and resistance. Our research is designed to prepare students for graduate and medical programs while contributing meaningful insights to the broader biomedical community.
1. Molecular and Cellular Mechanisms of Cancer
Using human cancer cell lines (SW480, CHTN06, SB051, SB521) as experimental models, students investigate:
Oncogenic signaling pathways driving tumor growth and proliferation.
Apoptosis and cell death regulation in response to therapeutic compounds.
Oxidative stress and metabolic alterations associated with cancer progression.
2. Natural Products and Cancer Therapeutics
Screening plant-derived compounds and dietary phytochemicals for anti-proliferative, pro-apoptotic, and anti-metastatic properties.
Exploring how natural products can sensitize cancer cells to existing treatments and reduce therapy resistance.
3. Translational and Interdisciplinary Approaches
Integrating molecular biology, pharmacology, and systems biology to identify potential therapeutic targets.
Collaborating across disciplines to bridge basic research with clinical relevance.
TBA
Lucia Suazo et al.
Evaluating Colorectal Cancer Responses to Garlic Extract.
Presented at Research and Creative Arts Day 2025 ( April 23, 2025) at Caldwell University.
Requires further data collection and analysis (2023–2024)
Students interested in pursuing cancer biology projects must secure a research grant (internal or external) to support costs associated with specialized reagents, assays, and maintenance of human cancer cell lines. This ensures sustainability of research and provides students with valuable experience in scientific proposal writing and grant management.
The NeuroBioImpact Lab emphasizes:
Rigorous training in experimental design, data analysis, and laboratory techniques.
Development of critical thinking, scientific writing, and presentation skills.
Interdisciplinary teamwork that prepares students for careers in academia, healthcare, and the life sciences industry.
Our cancer biology program benefits from:
Collaborations with Stony Brook School of Medicine (Dr. Jennie Williams) and Old Dominion University (Dr. Alvin Holder) to enhance translational research opportunities.
Cross-departmental partnerships at Caldwell University for interdisciplinary projects.
Engagement with community organizations, including the NJ Academy of Science and the National Association of Academies of Science, to broaden the impact of student research.
Interactions with Life Sciences Industry partners to connect academic discoveries with real-world applications.
Through cancer biology research, the NeuroBioImpact Lab empowers students to contribute to the fight against cancer while gaining the skills, knowledge, and professional networks needed to become the next generation of biomedical leaders.
Students: Aneel Pitchumoni, Paige Rawls, Sydney Hains, Sharaya Soni, Olivia Olson, Walter Steinmann, Elissa Pena, Lauren Elsky, Benjamin Misthal, Ella Perez