He became ill in early October 2006 because of a type of leukemia, which was the most aggressive one. When Carlo entered in the hospital, he knew that he would not get out. He offered the Lord his suffering to go straight to Heaven.

On October, 12th he died in a hospital in Italy called San Gerado de Monza. When he knew about his illness he made a video saying that he should be buried in Assisi.