Brandeis University

2023

Sanjoy Adak, Naike Ye, Logan A Calderone, Rebecca J B Schäfer, April L Lukowski, Maria-Eirini Pandelia, Catherine L Drennan, Bradley S Moore. 'Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme', bioRxiv,  link 

Jiahua Chen, Logan A. Calderone, Luying Pan, Trent Quist, Maria-Eirini Pandelia. ' The Fe and Zn cofactor dilemma', Biochim Biophys Acta Proteins Proteomics, link

2022

Sining Sun, Richard Wang, and Maria-Eirini Pandelia.'Vibrio cholerae V-cGAP3 Is an HD-GYP Phosphodiesterase with a Metal Tunable Substrate Selectivity',  Biochemistry 2022. link 

Michelle Langton, Matthew Appell, Jeremy Koob, and Maria-Eirini Pandelia. 'Domain Fusion of Two Oxygenases Affords Organophosphonate Degradation in Pathogenic Fungi', Biochemistry Comm 2022. link 

Sun S, He Z, Jiang P, Baral R, Pandelia ME.' Metal Dependence and Functional Diversity of Type I Cas3 Nucleases'  Biochemistry. 2022 Feb 21. doi: 10.1021/acs.biochem.1c00779. link 

Ueda C, Langton M, Chen J, Pandelia ME. 'The HBx protein from Hepatitis B Virus coordinates a redox-active Fe-S cluster.' J Biol Chem. 2022 Feb 8:101698. doi: 10.1016/j.jbc.2022.101698. link 

2021

Chie Ueda, Michelle Langton, Maria-Eirini Pandelia. 'Characterization of Fe-S Clusters in Proteins by Mӧssbauer Spectroscopy', Fe-S proteins in Methods in Molecular Biology, Springer, 2021, Pages 281-305. 

2020

Langton, M.; Sun, S.; Ueda, C.; Markey, M.; Chen, J.; Paddy, I.; Jiang, P.; Chin, N.; Milne, A.; Pandelia, M.-E. 'The HD-Domain Metalloprotein Superfamily: An Apparent Common Protein Scaffold with Diverse Chemistries'     Catalysts 2020, 10, 1191. link 

Michelle Langton, Maria-Eirini Pandelia, 'Hepatitis B Virus Oncoprotein HBx Is Not an ATPase', ACS Omega (2020), link

Sun Sining, Pandelia ME, 'HD-[HD-GYP] Phosphodiesterases: Activities and Evolutionary Diversification within the HD-GYP Family', Biochemistry, (2020), link-ahead of print

2019

Rose HR, Maggiolo AO, McBride MJ, Palowitch GM,Pandelia ME, Davis KM, Yennawar NH, Boal AK. 'Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis', Biochemistry, 58(14):1845-1860 (2019) link

Lauren Rajakovich, Maria-Eirini Pandelia, Andrew Mitchell, Wei-chen Chang, Bo Zhang, Amie K. Boal, Carsten Krebs, Martin J. Bollinger, Jr. ‘A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases’, Biochemistry, 58(12):1627-1647 (2019), link

R. Ayikpoe, T. Ngendahimana, M. Langton, S. Bonitatibus, L. Walker, S. Eaton, G. Eaton, M.E. Pandelia, S.J. Elliott, J. Latham. ‘Spectroscopic and electrochemical characterization of the mycofactocin biosynthetic protein, MftC, provides insight into its redox flipping mechanism, Biochemistry (2019), 10.1021/acs.biochem.8b01082

2018

Wittenborn EC, Merrouch M, Ueda C, Fradale L, Léger C, Fourmond V, Pandelia ME, Dementin S, Drennan CL.'Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase.',  Elife. 2018 Oct 2;7. pii: e39451. doi: 10.7554/eLife.39451.

Nitzan Koppel, Jordan E Bisanz, Maria-Eirini Pandelia, Peter J Turnbaugh , Emily P Balskus. 'Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins', eLife 2018

Rose H, Ghosh M, Maggiolo A, Pollock CJ, Blaesi EJ, Hajj V, Wei Y, Rajakovich LJ, Chang WC, Han Y, Hajj M, Krebs C*, Silakov A*, Pandelia ME*, Bollinger JM Jr*, Boal AK*. 'Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by its Dimanganese Cofactor' Biochemistry. 2018 Apr 2, published ahead of print

Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM Jr., Krebs C, Kelleher NL, Rosenzweig AC. 'The biosynthesis of methanobactin". Science. 2018 Mar 23;359(6382):1411-1416.

Thomas C. Pochapsky; Nathan Wong; Yihao Zhuang; Jeffrey Futcher; Maria-Eirini Pandelia; Drew R Tietz; Allison M Colthart "NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450.” Biochim Biophys Acta 2018 Jan;1866(1):126-133.

Previous Career

Dong M, Horitani M, Dzikovski B, Pandelia ME, Krebs C, Freed JH, Hoffman BM, Lin H. "Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme." J Am Chem Soc. 2016 Aug 10;138(31):9755-8.

Lanz ND, Lee KH, Horstmann AK, Pandelia ME, Cicchillo RM, Krebs C, Booker SJ (2016). "Characterization of Lipoyl Synthase from Mycobacterium tuberculosis."Biochemistry. 2016 Mar 8;55(9):1372-83.  

Aussignargues C, Pandelia ME, Sutter M, Plegaria JS, Zarzycki J, Turmo A, Huang J, Ducat DC, Hegg EL, Gibney BR, Kerfeld CA (2016). "Structure and Function of a Bacterial Microcompartment Shell Protein Engineered to Bind a [4Fe-4S] Cluster."  J Am Chem Soc. 2016 Apr 27;138(16):5262-70. 

Cox N, Nalepa A, Pandelia ME, Lubitz W, Savitsky A (2015). "Pulse Double-Resonance EPR Techniques for the Study of Metallobiomolecules." Methods Enzymol. 2015;563:211-49. 

Rajakovich LJ, Nørgaard H, Warui DM, Chang WC, Li N, Booker SJ, Krebs C, Bollinger JM Jr, Pandelia ME (2015). "Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism." J Am Chem Soc. 2015 Sep 16;137(36):11695-709.

Hadj-Saïd J, Pandelia ME, Léger C, Fourmond V, Dementin S (2015). "The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris." Biochim Biophys Acta. 2015 Dec;1847(12):1574-83.

Zhao Y, Vargas-Barbosa NM, Strayer ME, McCool NS, Pandelia ME, Saunders TP, Swierk JR, Callejas JF, Jensen L, Mallouk TE (2015). "Understanding the effect of monomeric iridium(III/IV) aquo complexes on the photoelectrochemistry of IrOx.nH2O-catalyzed water-splitting systems." J Am Chem Soc. 2015 Jul 15;137(27):8749-57.

Pandelia ME, Lanz ND, Booker SJ, Krebs C (2015). "Mössbauer spectroscopy of Fe/S proteins." Biochim Biophys Acta. 2015 Jun;1853(6):1395-1405.

Warui DM, Pandelia ME, Rajakovich LJ, Krebs C, Bollinger JM Jr, Booker SJ (2015). "Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase."Biochemistry 2015 Feb 3;54(4):1006-15.

Lanz ND, Pandelia ME, Kakar ES, Lee KH, Krebs C, Booker SJ (2014). "Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase."Biochemistry 2014, 53(28):4557-72.

Ludwig M, Pandelia ME, Chew CY, Zhang B, Golbeck JH, Krebs C, Bryant DA (2014). "ChlR protein of Synechococcus sp. PCC 7002 is a transcription activator that uses an oxygen-sensitive [4Fe-4S] cluster to control genes involved in pigment biosynthesis."J Biol Chem. 2014 Jun 13;289(24):16624-39.

Wörsdörfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME (2013). "Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases." Proc. Natl. Acad. Sci. USA, 2013, 110(47):18874-9.

Pandelia ME, Bykov D, Izsak R, Infossi P, Giudici-Orticoni MT, Bill E, Neese F, Lubitz W (2013). "Reply to Mouesca et al.: Electronic structure of the proximal [4Fe-3S] cluster of O2-tolerant [NiFe] hydrogenases." Proc Natl Acad Sci USA. 2013 Jul 9;110(28):E2539.

Banci L, Ciofi-Baffoni S, Mikolajczyk M, Winkelmann J, Bill E, Pandelia ME (2013). "Human anamorsin binds [2Fe-2S] clusters with unique electronic properties." J. Biol. Inorg. Chem., 2013, 18,pp 883-893.

Kampa M, Pandelia ME, Lubitz W, van Gastel M, Neese F (2013). "A metal-metal bond in the light-induced state of [NiFe] hydrogenases with relevance to hydrogen evolution." J. Am. Chem. Soc., 2013, 135(10):3915-25.

Pandelia ME, Bykov D, Izsak R, Infossi P, Giudici-Orticoni MT, Bill E, Neese F, Lubitz W (2013). "Electronic structure of the unique [4Fe-3S] cluster in O2-tolerant hydrogenases characterized by 57Fe Mossbauer and EPR spectroscopy." J. Am. Chem. Soc. 2013 135(42):15801-12.

Dassama LM, Jiang W, Varano PT, Pandelia ME, Conner DA, Xie J, Bollinger JM Jr, Krebs C (2012). "Radical-translocation intermediates and hurdling of pathway defects in 'super-oxidized' (Mn(IV)/Fe(IV)) Chlamydia trachomatis ribonucleotide reductase." J. Am. Chem. Soc., 2012, 20498–20506.

Flores M, Okamura MY, Niklas J, Pandelia ME, Lubitz W (2012). "Pulse Q-band EPR and ENDOR spectroscopies of the photochemically generated monoprotonated benzosemiquinone radical in frozen alcoholic solution." J Phys Chem B, 2012 August 2, 116(30):8890-900.

Pandelia ME, Lubitz W, Nitschke W (2012). "Evolution and diversification of Group 1 [NiFe] hydrogenases. Is there a phylogenetic marker for O(2)-tolerance?" Biochim Biophys Acta, 2012, 1817(9):1565-75.

Pandelia ME, Infossi P, Stein M, Giudici-Orticoni MT, Lubitz W (2012). "Spectroscopic characterization of the key catalytic intermediate Ni-C in the O2-tolerant [NiFe] hydrogenase I from Aquifex aeolicus: evidence of a weakly bound hydride." Chem. Communications, 2012, 48, 823-825.

Hoppe A, Pandelia ME, Gärtner W, Lubitz W (2011). "[Fe4S4]- and [Fe3S4]-cluster formation in synthetic peptides." BBA-Bioenergetics 1807, 11,1414-1422.

Pandelia ME, Nitschke W, Infossi P, Giudici-Orticoni MT, Bill E, Lubitz W (2011). "Characterization of a unique [FeS] cluster in the electron transfer chain of the oxygen tolerant [NiFe] hydrogenase from Aquifex aeolicus." Proc. Nat. Acad. Sci. USA 2011 Apr 12; 108(15): 6097–6102.

Millo D, Hildebrandt P, Pandelia ME, Lubitz W, Zebger I (2011). "SEIRA spectroscopy of the electrochemical activation of an immobilized [NiFe] hydrogenase under turnover and non-turnover conditions." Ang. Chemie Int. Ed. 2011 Mar 7;50(11):2632-4.

Pandelia ME, Infossi P, Giudici-Orticoni MT, Lubitz W (2010). "The oxygen-tolerant hydrogenase I from Aquifex aeolicus weakly interacts with carbon monoxide: an electrochemical and time-resolved FTIR study." Biochemistry. 2010 Oct 19;49(41):8873-81.

Kellers P, Pandelia ME, Currell LJ, Görner H, Lubitz W (2009). "FTIR study on the light sensitivity of the [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F: Ni-C to Ni-L photoconversion, kinetics of proton rebinding and H/D isotope effect." Phys. Chem. Chem. Phys. 11: 8680 – 8683. *Equal authorship.

Pandelia ME, Fourmond V, Tron-Infossi P, Lojou E, Bertrand P, Léger C, Giudici-Orticoni MT, Lubitz W (2010). "Membrane-bound hydrogenase I from the hyperthermophilic bacterium Aquifex aeolicus: enzyme activation, redox intermediates and oxygen tolerance." J Am Chem Soc. 2010 May 26;132(20):6991-7004.