Gonyea CR, Shen Y, Nelson KM, Bird RN, Gilbert RM, Olutoye OO 2nd, Keswani SG, Gleghorn JP. The nitrofen/bisdiamine murine model of congenital diaphragmatic hernia has a pulmonary hypertension vascular phenotype consistent with human CDH. Am J Physiol Lung Cell Mol Physiol. 2025 Jul 1;329(1):L48-L60. doi: 10.1152/ajplung.00233.2024. Epub 2025 May 30. PMID: 40445713; PMCID: PMC12235656.
Shen Y, Gleghorn JP. Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease. J Cardiovasc Transl Res. 2025 Apr;18(2):392-407. doi: 10.1007/s12265-024-10581-z. Epub 2025 Jan 16. PMID: 39821606; PMCID: PMC12043424.
Shen Y. Will Stub1 Be the Next Target for Pulmonary Hypertension Therapy Development? Am J Respir Cell Mol Biol. 2025 Sep;73(3):329-331. doi: 10.1165/rcmb.2025-0034ED. PMID: 40042807; PMCID: PMC12416299.
Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. Sci Rep. 2023 Apr 22;13(1):6593. doi: 10.1038/s41598-023-33779-8. PMID: 37087509; PMCID: PMC10122657.
Shen Y, Goncharov DA, Pena A, Baust J, Chavez Barragan A, Ray A, Rode A, Bachman TN, Chang B, Jiang L, Dieffenbach P, Fredenburgh LE, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Sci Signal. 2022 Dec 6;15(763):eabn2743. doi: 10.1126/scisignal.abn2743. Epub 2022 Dec 6. PMID: 36473049; PMCID: PMC9869933.
Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA, Kudryashova TV. Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Front Med (Lausanne). 2022 Jun 28;9:886868. doi: 10.3389/fmed.2022.886868. PMID: 35836951; PMCID: PMC9274086.
Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circ Res. 2022 Mar 4;130(5):760-778. doi: 10.1161/CIRCRESAHA.121.319100. Epub 2022 Feb 7. PMID: 35124974; PMCID: PMC8897250.
Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA. The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study. Front Med (Lausanne). 2022 Jan 10;8:751338. doi: 10.3389/fmed.2021.751338. PMID: 35083230; PMCID: PMC8784691.
Sarode GV, Neier K, Shibata NM, Shen Y, Goncharov DA, Goncharova EA, Mazi TA, Joshi N, Settles ML, LaSalle JM, Medici V. Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation. Cell Mol Gastroenterol Hepatol. 2021;12(4):1457-1477. doi: 10.1016/j.jcmgh.2021.05.020. Epub 2021 Jun 4. PMID: 34098115; PMCID: PMC8487080.
Daneva Z, Marziano C, Ottolini M, Chen YL, Baker TM, Kuppusamy M, Zhang A, Ta HQ, Reagan CE, Mihalek AD, Kasetti RB, Shen Y, Isakson BE, Minshall RD, Zode GS, Goncharova EA, Laubach VE, Sonkusare SK. Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2023130118. doi: 10.1073/pnas.2023130118. PMID: 33879616; PMCID: PMC8092599.
Shen Y, Shi Z, Fan JT, Yan B. Dechlorination and demethylation of ochratoxin A enhance blocking activity of PXR activation, suppress PXR expression and reduce cytotoxicity. Toxicol Lett. 2020 Oct 10;332:171-180. doi: 10.1016/j.toxlet.2020.07.012. Epub 2020 Jul 10. PMID: 32659470; PMCID: PMC8279013.
Shen Y, Goncharov DA, Avolio T, Ray A, Okorie E, DeLisser H, Mora AL, Vanderpool R, Kudryashova TV, Goncharova EA. Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats. Pulm Circ. 2020 Feb 12;10(1):2045894019898593. doi: 10.1177/2045894019898593. PMID: 32110386; PMCID: PMC7016388.
Shen Y, Lau-Cam CA. Taurine Enhances the Protective Actions of Fish Oil Against D-Galactosamine-Induced Metabolic Changes and Hepatic Lipid Accumulation and Injury in the Rat. Adv Exp Med Biol. 2019;1155:71-85. doi: 10.1007/978-981-13-8023-5_7. PMID: 31468387.
Zuo TT, Li YL, He HZ, Jin HY, Zhang L, Sun L, Gao F, Wang Q, Shen YJ, Ma SC, He LC. Refined assessment of heavy metal-associated health risk due to the consumption of traditional animal medicines in humans. Environ Monit Assess. 2019 Feb 19;191(3):171. doi: 10.1007/s10661-019-7270-1. PMID: 30783770.
Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA. Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Sep 28;19(10):2957. doi: 10.3390/ijms19102957. PMID: 30274147; PMCID: PMC6212879.
Shen YS, Goncharova EA. TWISTed HIF: revisiting smooth muscle HIF-1α signaling in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L387-L389. doi: 10.1152/ajplung.00285.2018. Epub 2018 Jul 5. PMID: 29975104; PMCID: PMC6172622.
Shen Y, Yan B. Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil. J Hepatol. 2017 Mar;66(3):660-661. doi: 10.1016/j.jhep.2016.11.025. Epub 2016 Dec 10. PMID: 27965153; PMCID: PMC8297416.
Parikh MC, Patel SN, Shen Y, Lau-Cam CA. Role of taurine on the actions of alcohol against systemic and cardiac biochemical changes in the diabetic rat. Adv Exp Med Biol. 2015;803:313-38. doi: 10.1007/978-3-319-15126-7_25. PMID: 25833507.
Gu X, Zhang W, Liu J, Shaw JP, Shen Y, Xu Y, Lu H, Wu Z. Preparation and characterization of a lovastatin-loaded protein-free nanostructured lipid carrier resembling high-density lipoprotein and evaluation of its targeting to foam cells. AAPS PharmSciTech. 2011 Dec;12(4):1200-8. doi: 10.1208/s12249-011-9668-0. Epub 2011 Sep 17. PMID: 21927961; PMCID: PMC3225525.