Clinical Research
On-going Investigator Initiated Research
Effectiveness of myopia control treatments – a retrospective cohort study of Myopia Control Clinic of UC Berkeley Eye Center
Higher order aberrations induced by novel contact lenses for myopia control
Role of dynamic pupillometry in guiding novel CL designs for better visual performance and more predictable imposed defocus as myopia-inhibiting dosage
Short-term choroidal responses to novel SCL for myopia control
Optimizing contact lens designs to maximize anti-myopia efficacy
Developing and evaluating customized algorithms in the quantification of post-OrthoK corneal topographical changes and its impact on myopia control
Short- and intermediate-term clinical surrogate markers for long-term anti-myopia efficacy
On-going Industry sponsored Multi-Centered Clinical trials (PI Sarah Singh)
CHAMP Study
Can an atropine eye drop used daily before bedtime can safely slow the progression of myopia in children?
The CHAMP study is a multicenter, double-masked, placebo-controlled study that's ongoing at more than 20 sites across the US and Europe. Closed for enrollment.
Chaperone Study
Is low concentration atropine delivered in a microdose dispenser effective in slowing progression of pedatric myopia?
The Chaperone study is a U.S.-based, multi-center, randomized, double-masked trial where low contractoin atropine is delivered as a gentle mist with a specialized dispenser. Each mist of the medication is about ¼ the volume of an eye drop.
*open for enrolment*
Past Research & Selected Peer-Reviewed Publications
K M. Alanazi,Essam S. Almutleb,Yousef S. Badawood,Mohammed A. Kudam,M Liu.Perspectives and clinical practices of optometrists in Saudi Arabia concerning myopia in children.Int J Ophthalmol 2023;16(2):267-273,doi:10.18240/ijo.2023.02.14
Alanazi M, Caroline P, Alshamrani A, Alanazi T, Liu M. Visual Performance with Multifocal Corneal Gas-Permeable Contact Lenses in Young Adults: A Pilot Study. Journal of Optometry 15 (4), 305-312
Alanazi M, Caroline P, Alshamrani A, Alanazi T, Liu M. Regional Distribution of Choroidal Thickness and Diurnal Variation in Choroidal Thickness and Axial Length in Young Adults. Clin Ophthalmol. 2021;15:4573-4584 https://doi.org/10.2147/OPTH.S334619
Liu M. Contributing author. IMI - Prevention of Myopia and its Progression. IOVS April 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.5.6
Liu M. Contributing author. IMI – Clinical Management Guidelines Report. IOVS. February 2019, Vol.60, M184-M203. doi:10.1167/iovs.18-25977
Y Zhang, Y Liu, Y Hang, et al. Differential gene expression of BMP2 and BMP receptors in chick retina & choroid induced by imposed optical defocus. Vis Neurosci. 2016 Jan;33:E015. doi: 10.1017/S0952523816000122.
T Aller, Y Liu, C Wildsoet. Myopia control with bifocal contact lenses: a randomized clinical trial. Optom Vis Sci. 2016 Jan 18 Epub
Y Liu and P Xie. Safety of orthokeratology – a systematic review. Eye and Contact Lens. 2016 Jan;42(1):35-42
Y Zhang, Y Liu, C Ho, CF Wildsoet. Effects of imposed defocus of opposite sign on temporal gene
expression patterns of BMP4 and BMP7 in chick RPE. Experimental Eye Research (2013), http://dx.doi.org/10.1016/j.exer.2013.02.010.
Y Liu and C.F. Wildsoet. The effective add inherent in 2-zone negative lenses inhibits eye growth in young chicks. IOVS 2012, Jul;53(8):5085-93
Y Zhang, Y Liu, and C.F. Wildsoet. Bidirectional, Optical Sign-Dependent Regulation of BMP2 Gene Expression in Chick Retinal Pigment Epithelium. IOVS 2012, Sep; 53(10): 6072-80
L Ostrin, Y Liu, V Choh, and C.F. Wildsoet. The role of iris in chick accommodation. IOVS 2011 Jul 1;52(7):4710-6
Y Liu and C.F. Wildsoet. The effect of 2-zone concentric bifocal spectacle lenses on refractive error
development and eye growth in young chicks. IOVS. 2010, Sep; 10.1167 doi:https://doi.org/10.1167/iovs.10-5716
I Vedamurthy, W Harrison, Y Liu, I Cox, and CM Schor. The influence of first near-spectacle reading correction on accommodation and its interaction with convergence. IOVS. 2009, Sep;50(9):4215-22
Our Research Instruments
Topcon MYAH
Multi-functional instrument including biometry (OLCR platform), corneal topography, dynamic pupillometry, anterior cornea wavefront analysis and contact lens fitting software
Topcon Triton SS-OCT
Swept-source technology for deeper penetration through cataracts, hemorrhages, gas bubbles and other media opacities. 100 kHz scanning speed for fewer motion artifacts and better image quality than SD-OCT.
Topcon Maestro OCT-A
Automated OCT-Fundus Camera system allowing for detailed visualization of macula, optic disc and anterior segment
Topcon SP-1P
Automated specular microscope for fast and accurate imaging and analysis of endothelial cells
Medmont Meridia
Multifunctional placido-based topography, anterior segment videography, and dry eye analysis
Haag-Streit Lenstar 500
OLCR-based biometer and static pupillometry
Rotlex Optical Profiler
Objective, accurate and repeatable power measurements of all types of refractive contact lenses, in air and in solution
Grand Seiko Autorefractor
Binocular autorefraction/keratometer that measures refractive error and accommodation in natural viewing condiction