Optical interrogation of receptors in brain circuits
Optical interrogation of receptors in brain circuits
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- Photoswitchable GABAa receptors can integrate into synapses, allowing optical control of inhibitory postsynaptic currents in the brain.
from Lin et al., Neuron 2015
Functional Receptor Connectomics
Functional Receptor Connectomics
- Photocontrol of specific types of GABAa receptor reveals unique contributions at different inhbitory synapses in the cortical microcircuit.
Contribution of the alpha-1 receptor to individual synapses
Contribution of the alpha-1 receptor to all synapses in the circuit
- Photocontrol can be achieved in the brain of awake, behaving mice.
- Photocontrol in visual cortex implicates a specific GABAa receptor as critical for sensory-elicited oscillations.
- Photocontrol of a different GABAa receptor in hippocampus reveals a critical role in learning and memory.
from Lin et al., Neuron, 2015
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