SCHOLARLY WORK
EMPIRICAL PEER-REVIEWED PUBLICATIONS
BOOKS
D’Esposito M (Editor). Neurological Foundations of Cognitive Neuroscience,
MIT Press, 2002.
Devinsky O & D’Esposito M. The Neurology of Cognitive and Behavioral Disorders,
Oxford University Press, 2003.D’Esposito M (Editor). Functional MRI: Applications in Clinical Neurology and Psychiatry, Taylor & Francis, 2006.
Osaka N, Logie R, D’Esposito M (Editors), Working Memory: Behavioral and Neural Correlates, Oxford University Press, 2007.
Jagust W & D’Esposito M (Editors), Imaging the Aging Brain, Oxford University Press, 2009.
D’Esposito M & Grafman J. The Frontal Lobes, Handbook of Neurology, Elsevier, 2019.
BOOK CHAPTERS/ REVIEWS/COMMENTARIES
METHODOLOGICAL
D’Esposito M, Zarahn E, Aguirre G. Event-related fMRI: implications for cognitive psychology, Psychological Bulletin, 125:155-64, 1999.
Aguirre GK, D’Esposito M. Experimental Design for Brain fMRI. In CTW. Moonen & PA Bandettini (Eds.), Functional MRI (pp. 369-380). Berlin: Springer Verlag, 1999.
D’Esposito M. Functional neuroimaging studies of cognition, Seminars in Neurology, 20:487-498, 2000.
Millman KJ, D'Esposito M. Data and Analysis Management for Functional Magnetic Resonance Imaging Studies, Proceedings of the 2nd International Advanced Database Conference, M. Amin et al., Eds., US Education Service, June 2006.
D’Esposito M. Functional MRI: Cognitive Neuroscience Applications. In: SH Faro & FB Mohamed (Eds.) Functional MRI. Springer-Verlag, Berlin, 468-495, 2006.
Gazzaley, A, D’Esposito M. Considerations for the application of BOLD fMRI to neurological impaired populations, In: Deluca J., Hillary F. Functional Neuroimaging of Neurological Disorders, Guilford Publications, New York, NY, 2007.
D’Esposito M, Kayser A, Chen A. Functional MRI: Applications in Cognitive Neuroscience. In: M. Filippi (Ed.) Functional MRI Techniques and Protocols. Humana Press, 2009.
D’Esposito M, Kayser A, Chen A. Functional MRI: Cognitive Neuroscience Applications. In: SH Faro, FB Mohamed, M Law, JT Ulmer (Eds.) Functional Neuroradiology: Principles and Clinical Applications. Springer-Verlag, Berlin, 2011.
Kayser AS, D’Esposito M. Neurotechnologies. In: V.S. Ramachandran, Editor. Encyclopedia of Human Behavior, 2nd Edition, Elsevier, Oxford, UK, 2012.
D’Esposito M. Why methods matter in the study of the biological basis of the mind: a behavioral neurologist’s perspective. Reuter-Lorenz P.A., Baynes K, Mangun G.R., Phelps E.A. The Cognitive Neuroscience of Mind: A Tribute to Michael Gazzaniga, MIT Press, Cambridge, MA, 2010.
D’Esposito M, Sreenivasan K, Kayser A. Functional MRI: Cognitive Neuroscience Applications. In: K. Ugurbil, K. Uludag, L.J. Berliner, Editors. FMRI: From Nuclear Spins to Brain Function, Springer, New York, 2015.
Wittmann B, D’Esposito M. Functional Magnetic Resonance Imaging. In: H. Cooper, Editor, APA Handbook of Research Methods in Psychology, American Psychological Association, Washington, DC, 2012.
Cole MA, Soda CN, D’Esposito M. History of Functional Brain Imaging. In: B. Barr, L. Bielauskas (Eds.) The Oxford Handbook of the History of Clinical Neuropsychology, Oxford University Press, Oxford, 2016.
Kayser AS, D’Esposito M. Neurotechnologies. In: Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, Oxford, UK, 2017.
D’Esposito M. Are individual differences in human brain organization measured with functional MRI meaningful? Proceedings of the National Academy of Sciences, 116:22432-22434, 2019.
Kayser A, Chen A, D’Esposito M. Functional MRI: Cognitive Neuroscience Applications. In: SH Faro, FB Mohamed, M (Eds.) Functional Neuroradiology: Principles and Clinical Applications (2nd Edition). Springer-Verlag, Berlin, 2023
Helfrich RF, Knight RT, D’Esposito M. Methods to Study Human Memory. In: M.J. Kahana, A.D. Wagner (Eds.) The Oxford Handbook of Human Memory, Oxford University Press, New York, 2023.
WORKING MEMORY/COGNITIVE CONTROL/EXECUTIVE FUNCTION
D’Esposito M, Grossman M. The physiological basis of executive functioning and working memory. The Neuroscientist, 2:345-352,1996.
Kimberg DY, D’Esposito M, Farah MJ. Cognitive functions in the prefrontal cortex: working memory and executive control, Current Directions in Psychological Science6:185-192, 1998.
D’Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies, Experimental Brain Research, 133:3-11, 2000.
D’Esposito M. The neural basis of working memory: evidence from neuropsychological, pharmacological and neuroimaging studies. In: Connor L, Obler LK. Neurobehavior of Language and Cognition: Studies of Normal Aging and Brain Damage, Kluwer Academic Publishers, pp. 197-200, 2000.
Kimberg, DY, D'Esposito, M. Frontal lobes II: Cognitive issues. In: Farah, Martha J. Martha J. Farah, Todd E. Feinberg, Ed. Patient-based approaches to cognitive neuroscience. pp. 317-326, The MIT Press: Cambridge, MA, 2000.
D’Esposito M, Postle BR. Neural correlates of component processes of working memory: evidence from neuropsychological and pharmacological studies, Attention & Performance XVIII “Control of Cognitive Processes”, (Eds. S. Monsell, J. Driver), 2000.
D’Esposito M. Working Memory. In: R. Cabeza, A. Kingstone. Handbook of Functional Neuroimaging of Cognition, pp. 293-327, MIT Press, Cambridge, MA, 2001.
D’Esposito M, Postle BR. The neural basis of working memory storage, rehearsal and control processes: evidence from patient and functional MRI studies. In: L.S. Squire & D. Schacter (Eds.) Neuropsychology of Memory, Third Edition. Guilford, New York, 2002.
D’Esposito M, Postle BR, Rypma B. The role of lateral prefrontal cortex in working memory: Evidence from event-related fMRI studies. In: Hirata, K., Koga, Y., Nagata, K. & Yamazaki, K. (Eds.), Recent Advances in Human Brain Mapping. New York: Elsevier, 2002.
D’Esposito M, Postle BR. The organization of working memory function in lateral prefrontal cortex: evidence from event-related functional MRI. In: DT Stuss & RT Knight (Eds.) Principles of Frontal Lobe Function. Oxford University Press, New York, 2002.
D’Esposito M. Executive Function and Frontal Systems. In: B. S. Fogel, R. B. Schiffer, & S. M. Rao (Eds.), Neuropsychiatry, Baltimore, MD: Williams and Wilkins, 2003.
Curtis C, D’Esposito M. The meaning of persistent prefrontal activity during working memory delays: evidence from functional neuroimaging, Trends in Cognitive Science, 7:415-423, 2003
Ranganath C, D’Esposito M. Directing the mind’s eye: Prefrontal, inferior, and medial temporal mechanisms for visual working memory, Current Opinion in Neurobiology, 15:175-82, 2005.
Miller BT, D’Esposito M. Searching for the “top” in top-down control?” Neuron, 48:535-8, 2005.
Curtis CE, D’Esposito M. Working Memory. In: R. Cabeza, A. Kingstone. Handbook of Functional Neuroimaging of Cognition, 2nd Edition, MIT Press, Cambridge, MA, 2006.
Gazzaley A, D’Esposito M. Top-down modulation in visual working memory. In: Osaka N, Logie R, D’Esposito M (Editors), Working Memory: Behavioral and Neural Correlates, Oxford University Press, 2007.
D'Esposito M. From cognitive to neural models of working memory, Phil. Trans. Biol. Sc., 362: 761-72, 2007.
Gazzaley A, D’Esposito M. Unifying the prefrontal Cortex: executive control, neural networks and top-down modulation. In: Miller B., Cummings JL. The Human Frontal Lobes, 2nd Edition, Guilford Publications, New York, NY, 187-206, 2006.
D’Esposito M. Attention, please! How your brain manages its need to heed. In Mind Matters, the Scientific American blog on science and mind. http://www.scientificamerican.com/blog/post.cfm?id=attention-how-your-brain-manages-it , Oct 16, 2007.
D’Esposito M. Working Memory. In: M. Aminoff, F. Boller, R. Swaab, Handbook of Clinical Neurology, 3rd Ed., Neuropsychology and Behavioral Neurology (B. Miller, G. Goldenberg, series editors), Elsevier, U.K., 88:237-247, 2008.
Buchsbaum BR. D’Esposito M. Short term and working memory systems. In: J.H Byrne, Editor. Learning and Memory: A Comprehensive Reference, Elsevier, Oxford, U.K., Vol 3:237-260, 2008.
Curtis C, D’Esposito M. The inhibition of unwanted actions. In: E Morsella, J Bargh, P Gollwitzer, Oxford Handbook of Action, Oxford University Press, UK, 2008.
D'Esposito M. From cognitive to neural models of working memory, In: J.Driver, P Haggard, T Shallice, Editors. Mental Processes in the Human Brain, Oxford University Press, Oxford, U.K., 2008.
Badre D, D’Esposito M. Is the rostro-caudal axis of the frontal lobe hierarchical? Nature Reviews Neuroscience, 10:659-69, 2009.
Buchsbaum BR, D’Esposito M. Is there anything special about working memory? In: F Rösler, C Ranganath, B Röder, RH Kluwe (Eds.) Neuroimaging and Psychological Theories of Human Memory, Oxford University Press, Oxford, U.K., 2009.
D’Esposito M, Badre D. Combining the insights derived from lesion and fMRI studies to understand the function of prefrontal cortex. In: Levine, B. Craik, F.I.M. Mind and the Frontal Lobes: Cognition, Behavior, and Brain Imaging. Oxford University Press, New York, 2011.
Buchsbaum BR, D’Esposito M. Working Memory. In: K. Ochsner, S. Kosslyn, Editors. Oxford Handbook of Cognitive Neuroscience, Oxford University Press, Oxford, U.K., 2013.
Sreenivasan KK, Curtis CE, D’Esposito M. Revising the role of persistent neural activity in working memory, Trends in Cognitive Science, 18:82-89, 2014.
D’Esposito M, Postle BR. The cognitive neuroscience of working memory, Annual Reviews of Psychology, 66:115-42, 2015.
Nee, DE, D’Esposito, M. Working memory. In A.W. Toga (Ed.), Brain Mapping: An Encyclopedic Reference. Academic Press: Elsevier, 2015.
Nee DE, D’Esposito M. The representational basis of working memory. In: Clark RE, Martin S (Eds.) Behavioral Neuroscience of Learning and Memory, Springer Berlin Heidelberg, New York, 2016.
D’Esposito M, Kayser A, Chen A. Functional MRI: Applications in Cognitive Neuroscience. In: M. Filippi (Ed.) Functional MRI Techniques and Protocols, 2nd Edition. Springer, New York, 2016.
Buchsbaum BR, D’Esposito M. Short Term and Working Memory. In: H. Eichenbaum (ed.) Learning and Memory: A Comprehensive Reference, 2nd Edition, J.H. Byrne (ed.), Oxford:Academic Press, UK, 263-274, 2017
Gazzaley A, Lee TG, D’Esposito M. The Frontal Lobes and Executive Control. In: Miller B., Cummings JL. The Human Frontal Lobes, 3rd Edition, Guilford Publications, New York, NY, 2017.
Scimeca JM, Kiyonaga A, D'Esposito M. Reaffirming the Sensory Recruitment Account of Working Memory. Trends in Cognitive Science. 22:190-192, 2018.
Buchsbaum BR, D’Esposito M. A sensorimotor view of working memory, Cortex, 112:134-148, 2019.
Sreenivasan KK, D’Esposito M. The what, where and how of delay activity, Nature Reviews Neuroscience, 20:466-481, 2019.
Kiyonaga A, D’Esposito M. Competition and control during working memory, In: M. Chun (Ed) The Cambridge Elements of Perception, Cambridge University Press, Cambridge, UK, 2020.
Hwang K, D’Esposito M. The human thalamus in cognitive control. In: M. Halassa (Ed.) The Thalamus, Cambridge University Press, Cambridge, 2022.
Miller JA, D’Esposito M, Weiner KS. Using tertiary sulci to map the “cognitive globe’ of prefrontal cortex, Journal of Cognitive Neuroscience, in press.
COGNITION: OTHER
Johnson MK, Hayes SM, D’Esposito M, Raye CL. Confabulation. In: L.S. Cermak (Ed). Handbook of Neuropsychology (2nd Edition, Vol. 2), Elsevier Science:Amsterdam, pp. 359-383, 2001.
Ranganath C, Lokendra S, D’Esposito, M. A new view of the medial temporal lobes and the structure of memory. Technical Report. International Computer Science Institute, Berkeley, CA. 2002.
Klein HE, D’Esposito M. Neurocognitive inefficacy of the strategy process, Annals of the New York Academy of Science, 1118: 163–185, 2007.
Cohen JR, D’Esposito M. An integrated, dynamic functional connector underlies intelligence, In: A.K. Barbey, S Karama, RJ Haier (Eds.) The Cambridge Handbook of Intelligence and Cognitive Neuroscience, Cambridge University Press, Cambridge, UK, 2021.
NEUROPHARMACOLOGY
D’Esposito M, Albert M. The pharmacology of memory, In: Memory and Aging, Symposium of the National Foundation of Gerontology, Paris, France, 1991.
D’Esposito M. Dopamine in cerebral aging: the key to memory, Brochure. Servier International, France, 2002.
Cools R, D’Esposito M. Dopaminergic modulation of flexible cognitive control in humans. Björklund A., Dunnett S.B, Iversen L.L., Iversen S.D. Dopamine Handbook, Oxford University Press, Oxford, 2009.
Cools R, D’Esposito M. Inverted-U shaped dopamine actions on human working memory and cognitive control, Biological Psychiatry, 69(12):e113-125, 2011.
Vogelsang DA, D’Esposito M. Is there evidence for a rostral-caudal gradient in fronto-striatal loops and what role does dopamine play?, Frontiers in Decision Neuroscience, 12:242, 2018.
AGING
D’Esposito M. Cognitive aging: new answers to old questions, Current Biology, 9:R939-R941, 1999.
D’Esposito M, Weksler ME. Brain aging and memory: new findings help differentiate forgetfulness and dementia, Geriatrics, 55:55-62, 2000.
Rypma B, D’Esposito M. Age-related changes in brain-behavior relationships: evidence from event-related functional MRI studies, In: U.Mayr, D.Spieler & R.Kliegl (Eds.). Ageing and executive control. Psychology Press, Hove, UK, 2001.
Gazzaley A, D'Esposito M. The contribution of functional brain imaging to our understanding of cognitive aging. Science's SAGE KE, http://sageke.sciencemag.org/cgi/content/full/sageke; 2003/4/pe2, 29 Jan 2003.
D’Esposito M, Deouell L, Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: A challenge for neuroimaging. Nature Reviews Neuroscience, 4:863-72, 2003.
Gazzaley A, D’Esposito M. BOLD fMRI and Cognitive Aging. In: R. Cabezza, D. Park, L. Nyberg. Squire & D. Schacter (Eds.) Cognitive Neuroscience of Aging. Oxford University Press, New York, 2005.
Gazzaley A, D’Esposito M. Top-down modulation and normal aging, Annals of the New York Academy of Sciences, 1097: 67-83, 2007.
Samenez-Larking GR, D’Esposito M. Group comparisons: imaging the aging brain, Social, Cognitive and Affective Neuroscience, 3:290-297, 2008.
Gazzaley A, Clapp W, Kelley J, McEvoy K, Knight RT, D’Esposito M. Age-related top-down suppression deficit in the early stages of cortical visual memory processing, Proceeding of the National Academy of Sciences, 105:13122-13126, 2008.
Turner GR, D'Esposito, M. Functional Neuroimaging of Aging. In: Knoefel J, Albert ML. Clinical Neurology of Aging, 3rd Edition, Oxford University Press, Oxford, CA, 2011.
Rajah MN, Bastianetto S, Bromley-Brits K, Cools R, D’Esposito M, Grady CL, Poirier J, Quirion R, Raz N, Rogaeva E, Song EW, Pruessner J. Biological changes associated with healthy versus pathological aging: a symposium review, Aging Research Reviews, 8:140-6, 2009.
CLINICAL
D’Esposito M, Alexander MP. The clinical profiles, recovery and rehabilitation of memory disorders, Neurorehabilitation, 5:141-159, 1995.
D’Esposito M. (1997) Specific stroke syndromes. In: VM Mills, JW Cassidy, DI Katz, Neurologic Rehabilitation: A Guide to Diagnosis, Prognosis, and treatment planning, Cambridge, Blackwell Science, pp. 59-103.
D’Esposito M. (1998) Serotonin neurotoxicity: implications for cognitive neuroscience and neurology, Neurology, 51:1529-30.
Aguirre GK, D’Esposito M. Topographical disorientation: a synthesis and taxonomy, Brain, 122:1613-1628, 1999.
D’Esposito M. Post-concussive syndrome. In: M. Stern, M. Brown. Penn Neurology 2000: Management of Common Neurological Problems, 2000.
Ances BM, D’Esposito M. Functional neuroimaging of recovery of function after stroke: implications for rehabilitation, Neurorehabilitation and Neural Repair, 14:171-179, 2000.
D’Esposito M, Gazzaley A. Neurorehabilitation of Executive Function. In: M.E. Selzer, L. Cohen, F.H. Gage, S. Clarke, P.W. Duncan (Eds.) Textbook of Neural Repair and Rehabilitation, Cambridge University Press, Cambridge, U.K., pp. 475-487, 2005.
Chen AJW, Abrams GM, D’Esposito M. Functional re-integration of prefrontal neural networks for enhancing recovery after brain injury, Journal of Head Trauma Rehabilitation, 21:107-118, 2006.
Boettiger CA, D’Esposito M. Addiction. In: Feinstein, S. (Ed.) Encyclopedia of the Brain and Learning. Greenwood Publishing Group, 2006.
D’Esposito M, Chen, AJW. Neural mechanisms of prefrontal cortical function: Implications for cognitive rehabilitation. In: Aage R. Møller, Sandra Bond Chapman and Stephen G. Lomber. “Reprogramming the Human Brain,” Progress in Brain Research, 2006.
Van Boven RW, Harrington GS, Hackney DB, Ebel A, Gauger G, Bremmer JD, D’Esposito M, Detre JA, Haacke EM, Jack CR, Jagust WJ, Le Bihan D, Mathis CA, Mueller S, Mukherjee P, Schuff N, Chen, AJW, Weiner M. Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder, Journal of Rehabilitation Research and Development, 46:717-57, 2009.
Chen AJ, D'Esposito, M. Traumatic brain injury: from bench to bedside to society, Neuron, 66:11-14, 2010.
D’Esposito M., Gazzaley A. Can age-associated memory decline be treated? New England Journal of Medicine, 365:1346-7, 2011. D’Esposito M, Chen AJW. Remediating frontal lobe dysfunction: from bench to bedside. In: DT Stuss & RT Knight (Eds.) The Oxford Handbook of Frontal Lobe Functions. Oxford University Press, New York, 2013.
Turner GR, D’Esposito M. Neurorehabilitation of Executive Functions. In: M.E. Selzer, S. Clarke, Kwakkel, Miller (Eds.) Textbook of Neural Repair and Rehabilitation, Cambridge University Press, Cambridge, U.K., 2014.
Chen AJW, D’Esposito M. Plasticity in prefrontal cortical networks after brain injury: finding the optimal paths. In: J.I. Tracy, B. Hampstead, K. Sathian (Eds.) Cognitive Plasticity in Neurologic Disorders, Oxford University Press, Oxford, U.K., 2015.
Kayser AS, Ballard ME, D’Esposito M. Working Memory and Traumatic Brain Injury. In: T Packiam Alloway (Ed.) Working Memory and Developmental Disorders, Taylor & Francis, Oxon, UK, 2018.
Gallen CL, D’Esposito M. Brain Modularity: a biomarker of intervention-related plasticity, Trends in Cognitive Sciences, 23:293-304, 2019.
Dawson WD, Smith E, Ibanez A… D’Esposito M… Eyre HA. Build Back Brainier! Base Policies on Brain Science, In: W Hynes, I Linkov, P Love (Eds.) New Approaches to Economic Challenges: Systemic Recovery, OECD Publishing, Paris, 2022.
Chapman, S.B., Robertson, I.H., Zientz, J., Eyre, H., Ling, G., D’Esposito, M. The neuroscience of brain health. In J.M. Rippe (Ed.). Lifestyle Medicine (4th Edition). Boca Raton, FL: CRC Press, 2023.
Motzkin JC, Kanungo I, D’Esposito M, Shirvalkar P. Network targets for therapeutic brain stimulation: towards personalized therapy for pain, Frontiers in Pain Research, 4:1156108, 2023.
POPULAR MEDIA/TALKS
Sane Society Interview (2012)
Congressional Neuroscience Caucus | The Center for BrainHealth® (2015)
The Real Social Network We Should Be Obsessed With: Our Brain (2018)
The Social Network That Matters Most: Your Brain (2022)
From the Neurology Clinic to the Lab and Back Again: Addressing Frontal Lobe Syndromes (2022)
A Tale About the Frontal Lobes as Told by a Neurologist (2023)
How To Optimize Cognitive Function and Brain Health (2024)
The Frontal Lobes: The Brain's CEO (2024)
Prefrontal Cortex and Dopaminergic System (2024)
Your Health. Matters - Optimize Your Brain Chemistry (2024)
Collective Insights - Cognitive Function (2025)
CONTRIBUTIONS TO PUBLIC POLICY