BRAIN Networks

The D'Esposito Cognitive Neuroscience and Neurology Lab studies the basic mechanisms underlying the large-scale network organization of the brain and its relationship to behavior using functional MRI (fMRI), electrophysiology, transcranial stimulation (TMS) and studies of patients with focal lesions.

For example, using a novel approach to analyze fMRI data collected from patients with focal brain lesions, we have discovered that critical connector hubs exist in the brain that preserves its modular structure (Gratton et al., 2012). Damage to these hubs disrupts network organization, impairing connectivity throughout the brain, even between regions remote from the injury. These findings provide a mechanism for the long-standing idea of “diaschisis” and provide a foundation for understanding recovery of function following brain injury. We have also demonstrated that measurements of network connectivity can serve as imaging “biomarkers”, which can predict who will or will not respond to therapies to improve cognition (Arnemann et al., 2015; Gallen et al., 2016).

Below is a full listing of our published work.

NETWORK PUBLICATIONS

Gratton C, Nomura E, Perez F, D’Esposito M. Focal brain lesions cause widespread disruption of the modular organization of the brain, Journal of Cognitive Neuroscience, 24(6):1275-85, 2012.
Sadaghiani S, Scheeringa R, Lehonge K, Morillon B, Giraud A-L, D’Esposito M, Kleinschmidt A., Alpha-band phase synchrony is related to activity in the fronto-parietal adaptive control network, Journal of Neuroscience, 32:14305-14310, 2012.
Blumenfeld RS, Nomura EM, Gratton C, D’Esposito M. Lateral prefrontal cortex is organized into parallel dorsal and ventral streams along the rostral-caudal axis, Cerebral Cortex, 23:2457-2466, 2013.
Gratton C, Lee TG, Nomura EM, D’Esposito M. The effect of theta-burst TMS on cognitive control networks, Frontiers in Systems Neuroscience, 7:124, 2013.
Blumenfeld RS, Bliss DP, Perez P, D’Esposito M. CoCoTools: Open-source software for building connectomes using the CoCoMac anatomical database, Journal of Cognitive Neuroscience, 26:722-45, 2014.
Cohen JR, Jacobs E, D’Esposito M. Quantifying the reconfiguration of intrinsic networks during working memory, PLoSOne, 9:e106636, 2014.
Gratton C, Lee TG, D’Esposito M. Perfusion MRI indexes variability in the functional brain effects of theta burst transcranial magnetic stimulation, PLoSOne, Jul 3;9(7):e101430, 2014.
Arnemann KL, Chen AJ, Novakovic-Agopian T, Gratton C, Nomura EM, D’Esposito M. Functional brain network modularity predicts response to cognitive training after brain injury. Neurology, 84:1568-74, 2015.
Sadaghiani S, D’Esposito M. Functional characterization of the cingulo-opercular network in the maintenance of intrinsic alertness, Cerebral Cortex, 25:2763-73, 2015.
Sadaghiani S, Kleinschmidt A, D’Esposito M. Dynamic intrinsic connectivity predicts perception, Proceedings of the National Academy of Sciences, 112:8463-8, 2015.
Bertolero MA, Yeo BTT, D’Esposito, M. The modular and integrative functional architecture of the human brain, Proceedings of the National Academy of Sciences, 112:E6798-807, 2015.
Gallen CL, Turner, GR, Areeba A, D’Esposito M. Reconfiguration of intrinsic brain network architecture to support executive control in normal aging, Neurobiology of Aging, 44:42-52, 2016.
Gallen CL, Baniqued PL, Chapman SB, Aslan S, Keebler M, Didehbani N, D’Esposito M. Modular brain network organization predicts response to cognitive training in older adults, PLoS One, 11:.e0169015, 2017.
Hwang K, Bertolero M, Liu W, D’Esposito M. The human thalamus is an integrative hub for functional brain networks, Journal of Neuroscience, 37:5594-5607, 2017.
Bertolero MA, Yeo BTT, D’Esposito, M. The Diverse Club: The Integrative Core of Complex Networks, Nature Communications, 8:1277, 2017.
Bertolero MA, Yeo BTT, Bassett DS, D’Esposito, M. A mechanistic model of connector hubs, modularity, and cognition, Nature Human Behavior, 2:765-777, 2018.
Baniqued PL, Gallen CL, Voss MW, Burzynska AZ, Wong CN, Cooke GE, Duffy K, Fanning J, Ehlers D, Salerno EA, Aguinaga S, McAuley E, Kramer AF, D’Esposito M. Brain network modularity predicts exercise-related executive function gains in older adults, Frontiers in Aging Neuroscience, 9:246, 2018.
Blumenfeld RS, Bliss DP, D’Esposito M, Turner GR. Quantitative anatomical evidence for dorsoventral and rostrocaudal segregation within the nonhuman primate frontal cortex, Journal of Cognitive Neuroscience, 30:353-364, 2018.
Hwang K, Shine JM, Jagadeesh A, D’Esposito M. Fronto-parietal activity interacts with task-evoked changes in functional connectivity, Cerebral Cortex, 29:802-813, 2019.
Baniqued PL, Gallen CL, Kranz MB, Kramer AF, D’Esposito M. Brain network modularity predicts cognitive training-related gains in young adults, Neuropsychologia, 131:205-215, 2019.
D’Esposito M. Are individual differences in human brain organization measured with functional MRI meaningful? Proceedings of the National Academy of Sciences, 116:22432-22434, 2019.
Hwang K, Shine JM, Cellier C, D’Esposito M. The human intraparietal sulcus modulates task-evoked functional connectivity, Cerebral Cortex, 29:802-813, 2019.
Sadaghiani S, Pascasie L. Dombert PL, Lovstad M, Funderud I, Meling TR, Endestad T, Robert T. Knight RT, Solbakk AK, D’Esposito M. Lesions to the fronto-parietal network impact alpha-band phase synchrony and cognitive control, Cerebral Cortex, 29:4143-4153, 2020.
Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Renier N, D’Esposito M, Contet C, Olivier G. Brain-wide functional architecture remodeling by alcohol dependence and abstinence, Proceedings of the National Academy of Sciences, 117:2149-2159, 2020.
Eichenbaum A, Pappas I, Lurie D, Cohen JR, D’Esposito, M. Differential contributions of static and time-varying functional connectivity to human behavior, Network Neuroscience, 5:145-165, 2021.
Cohen JR, D’Esposito M. An integrated, dynamic functional connector underlies intelligence, In: A.K. Barbey, S Karama, RJ Haier (Eds.) The Cambridge Handbook of Intelligence and Cognitive Neuroscience, Cambridge University Press, Cambridge, UK, 2021.
Menon V, D’Esposito M. The role of PFC networks in cognitive control and executive function, Neuropsychopharmacology, 47:90-103, 2022.
Cookson SL, D’Esposito M. Evaluating the reliability, validity, and utility of overlapping networks: Implications for cognitive control, Human Brain Mapping, 44(3):1030-1045, 2023.
Motzkin JC, Kanungo I, D’Esposito M, Shirvalkar P. Network targets for therapeutic brain stimulation: towards personalized therapy for pain, Frontiers in Pain Research, 4:1156108, 2023.

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