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Aims
Aims
To perform and explain the reactions of acid anhydrides
To perform and explain the reactions of acid anhydrides
To synthesise aspirin from 2-hydroxybenzoic acid
To synthesise aspirin from 2-hydroxybenzoic acid
A. Report & Analyse of Results
A. Report & Analyse of Results
1. Record the mass of dry aspirin obtained and its melting temperature range
Things to consider CPAC 5a
Things to consider CPAC 5a
5a - Uses appropriate software and/or tools to process data, carry out research and report findings.
· Carry out melting point analysis:
1. Has researched and recorded mp of aspirin form referenced & dated source
1. Confidently uses mp apparatus to assess mp of sample
2. Reports findings with date and citation
Things to consider CPAC 5b
Things to consider CPAC 5b
5b - Sources of information are cited demonstrating that research has taken place, supporting planning and conclusions.
· Use research to support their purity of aspirin sample obtained
· Use research to support conclusions drawn
· Compile a bibliography of texts from which material has been sourced in such a way that the reader may retrieve the information easily.
B. Evaluate your report by answering the questions
B. Evaluate your report by answering the questions
1. Which functional group of the 2-hydroxybenzoic acid reacts with the ethanoic anhydride?
2. Draw the structural formulae for the reactants and product involved in the formation of aspirin from 2-hydroxybenzoic acid.
3. Calculate the relative molecular masses of 2-hydroxybenzoic acid and aspirin.
4. Calculate the theoretical yield.
5. Calculate the percentage yield.
6. Why might the apparent yield be higher?
7. What would you expect to be the main impurity in your sample?
8. Research the melting point temperature of pure aspirin. Is this similar to the value you recorded? Why do you think there might have been a difference?
Math you will find useful
Math you will find useful
Substitute numerical values into algebraic equations using appropriate units for physical quantities
Learning Tip
Learning Tip
Percentage yield = (actual yield /expected yield) × 100
Required Resources
Required Resources
Core Parctical 16 - Student Sheet.docxConsult CLEAPSS Hazcards® 39,52,98A. Perform a risk assessment using up-to-date information before this practical is carried out
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