PUBLICATIONS

28. Huang, H.-C., Wang, T.-Y., Rousseau, J., Orlando, M., Mungaray M., Michaud, C., Plaisier, C., Chen, Z. B., and Wang, K.C.  Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis.  Biomaterials. 2024; 306: 122505. doi: 10.1016/j.biomaterials.2024.122505.

27. Ravi, K., Manoharan, T. J. M., Wang, K.-C., and Nikkhah, M. Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment. Biomaterials. 2024; 305: 122428. doi: 10.1016/j.biomaterials.2023.122428.

26. Cai, X, Wang, K.-C., and Meng, Z. Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression. Front Cell Dev Biol. 2021;9:673599. doi:10.3389/fcell.2021.673599 

25. Chang, Y.-J. and Wang, K.-C. Therapeutic perspectives of extracellular vesicles and extracellular microRNAs in atherosclerosis. Curr Top Membr. 2021;87:255-277. doi:10.1016/bs.ctm.2021.08.005 

24. Chang YJ, Li YS, Wu CC, Wang, K.-C., Huang, Z.-C., Chen, Z. B., and Chien S. Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication. Arterioscler Thromb Vasc Biol. 2019;39(12):2492-2504. doi:10.1161/ATVBAHA.119.312707 

23. Yeh, Y.-T., Wei, J., Thorossian, S., Nguyen, K., Hoffman, C., del Alamo, J. C., Serrano, R., Li, Y.-S., Wang, K.-C.*, and Chien S.*. MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells. Biomaterials. 2019;204:59-69. doi:10.1016/j.biomaterials.2019.03.003

22. Meng, Z., Qiu, Y., Lin, K.-C., Kumar, A., Placone J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., Moroishi, T., Luo, M., Plouffe, S. W., Diao, Y., Ye, Z., Park, H. W., Wang, Z., Yu, F.-X., Chien, S., Wang, C.-Y., Ren, B., Engler, A. J., and Guan, K.-L. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018;560(7720):655-660. doi:10.1038/s41586-018-0444-0 

21. Zhu, J.-J., Liu, Y.-F., Zhang, Y.-P., Zhao, C.-R., Yao, W.-J., Li, Y.-S., Wang, K.-C., Huang, T.-S., Pang, W., Wang, X., Chien, S., and Zhou, J. VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia. Proc Natl Acad Sci U S A. 2017;114(31):8271-8276. doi:10.1073/pnas.1700561114

20. Huang, T.-S., Wang, K.-C., Quon, S., Nguyen, P., Chang, T.-Y., Chen, Z., Li, Y.-S., Subramaniam, S., Shyy, J.,and Chien, S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017;49(7):339-345. doi:10.1152/physiolgenomics.00132.2016 

19. Lin, T.-Y., Wei, T.-W., Li, S., Wang, S.-C., He, M., Martin, M., Zhang, J., Shentu, T.-P., Xiao, H., Wang K.-C., Chen, Z., Chien, S., Tsai, M.-D., and Shyy, J. TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2016;113(52):15078-15083. doi:10.1073/pnas.1618773114 

18. Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S., and Chien, S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016;113(41):11525-11530. doi:10.1073/pnas.1613121113 

17. Hu*, CM, Fang, RH*, Wang, K.-C.*, Luk, B., Thamphiwatana, S., Dehaini, D., Angsantikul, P., Wen, C. H., Kroll, A. V., Carpenter, C., Ramesh, M., Patel, S. H., Zhu, J., Shi, W., Hofman, F. M., Chen T. C., Gao, W., Zhang K., Chien, S., Zhang, L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015;526(7571):118-121. doi:10.1038/nature15373. *Co-first author. 

16. Wang, K.-C., Nguyen, P., Weiss, A., Yeh, Y.-T., Chien, H. S., Lee, A., Teng, D., Subramniam, S., Li, Y.-S., Chien, S. MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow. Arterioscler Thromb Vasc Biol. 2014;34(7):1437-1445. doi:10.1161/ATVBAHA.114.303473

15. Zhou, J., Li, Y.-S., Wang, K.C., Chien, S. Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1. Cell Mol Bioeng. 2014;7(2):218-224. doi:10.1007/s12195-014-0325-z 

14. Zhou, J., Li, Y.-S., Nguyen P, Wang, K.-C., Weiss, A., Kuo, Y.-C., Chiu, J.-J., Shyy, J., Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013;113(1):40-51. doi:10.1161/CIRCRESAHA.113.280883 

13. Yeh, Y.-T., Hur, S.S., Chang, J., Wang, K.-C., Chiu, J.-J., Li, Y.-S., Chien, S. Matrix stiffness regulates endothelial cell proliferation through septin 9. PLoS One. 2012;7(10):e46889. doi:10.1371/journal.pone.0046889 

12. Hur, S.S., del Álamo J.C., Park, J.S., Li, Y.-S., Nguyen, H., Teng, D., Wang, K.-C., Flores, L., Alonso-Latorre, B., Lasheras, J. C., Chien, S. Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012;109(28):11110-11115. doi:10.1073/pnas.1207326109 

11. Fero, D., Wang, K.-C., Nguyen, P., Li, Y.-S. Ephrin-A1 Regulates Cell Remodeling and Migration. Cel. Mol. Bioeng. 4, 648–655 (2011). doi.org/10.1007/s12195-011-0212-9

10. Wu, W., Xiao, H., Laguna-Fernandez, A., Villarreal, G., Wang, K.-C., Geary, G. G., Zhang, Y., Wang, W.-C., Huang, H.-D., Zhou, J., Li, Y.-S., Chien, S., Garcia-Cardena, G., Shyy, J. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011;124(5):633-641. doi:10.1161/CIRCULATIONAHA.110.005108

9. Zhou, J., Wang, K.-C., Wu, W., Subramaniam, S., Shyy, J., Chiu, J.-J., Li, Y.-S., Chien, S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011;108(25):10355-10360. doi:10.1073/pnas.1107052108 

8. Wang, K.-C., Garmire, L.-X., Young, A., Nguyen, P., Trihn, A., Subramaniam, S., Wang, N., Shyy, J., Li, Y.-S., Chien, S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010;107(7):3234-3239. doi:10.1073/pnas.0914825107 

7. Chiang, Y., Wu, J., Wang, K.-C., Chou, S., Hu, Y. Varied properties of hepatitis-delta virus-like particles produced by baculovirus-transduced mammalian cells. The Open Biotechnology Journal. 2007. 1(1), 34-40.

6.  Chiang, Y., Wu, J., Wang, K.-C., Lai, C., Hu, Y. Efficient expression of histidine-tagged large hepatitis delta antigen in baculovirus-transduced baby hamster kidney cells. World J Gastroenterol. 2006. 12(10):1551-1557.

5. Ho, Y., Huang, S., Chung, Y., Wang, K.-C., Hu, Y. Transgene expression and differentiation of baculovirus-transduced human mesenchymal stem cells. J. Gene. Med. 2005. 7:860-8.

4.  Chen, Y., Wu, J., Wang, K.-C., Chiang, Y., Lai, C., Chung, Y., Hu, Y. Baculovirus-mediated production of HDV-like particles in mammalian cells using a novel oscillating bioreactor. J. Biotechnol. 2005. 118 (2): 135-47.

3. Wang, K.-C., Wu, J., Chung, Y., Ho, Y., Chang, M. D., Hu, Y. Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells. Biotechnol. Bioeng. 2004. 89: 464-473.

2. Hsu, C., Ho, Y., Wang, K.-C., Hu, Y. Investigation of optimal transduction conditions for baculovirus-mediated gene transfer into mammalian cells. Biotechnol. Bioeng. 2004. 88: 42-51.

1. Ho, Y., Chen, H., Wang, K.-C., Hu, Y. Highly efficient baculovirus-mediated gene transfer into chondrocytes. Biotechnol. Bioeng. 2004. 88: 643-651.