1
Biology
The Cell
BBC Radio 4 - In Our Time, The Cell
First observed by Robert Hooke in 1665, cells occur in nature in a bewildering variety of forms. Every organism alive today consists of one or more cells: a single human body contains up to a hundred trillion of them. The first life on Earth was a single-celled organism which is thought to have appeared around three and a half billion years ago. That simple cell resembled today's bacteria. But eventually these microscopic entities evolved into something far more complex, and single-celled life gave rise to much larger, complex multicellular organisms. But how did the first cell appear, and how did that prototype evolve into the sophisticated, highly specialised cells of the human body?
2
Biology
Microbiology
BBC Radio 4 - In Our Time, Microbiology
We have more microbes in our bodies than we have human cells. We fear them as the cause of disease, yet are reliant on them for processes as diverse as water purification, pharmaceuticals, bread-making and brewing. In the future, we may look to them to save the planet from environmental hazards as scientists exploit their ability to clean up pollution. For microbes are the great recyclers on the earth, processing everything – plants, animals and us. Without microbes life would grind to a halt. How did we first discover these invisible masters of the universe? The development of microscopes in the 17th Century played a key part, but for a while science seemed stuck in this purely observational role. It is only when Louis Pasteur and Robert Koch began to manipulate microbes in the lab two hundred years later that stunning advances were made. These breakthroughs led to an understanding of how microbes transform matter, spread disease and also prevent it with the development of antibiotics and vaccines.
3
Biology
Fungi
BBC Radio 4 - In Our Time, Fungi
These organisms are not plants or animals but a kingdom of their own. Millions of species of fungi live on the Earth and they play a crucial role in ecosystems, enabling plants to obtain nutrients and causing material to decay. Without fungi, life as we know it simply would not exist. They are also a significant part of our daily life, making possible the production of bread, wine and certain antibiotics. Although fungi brought about the colonisation of the planet by plants about 450 million years ago, some species can kill humans and devastate trees.
4
Biology
Bacteriophages
BBC Radio 4 - In Our Time, Bacteriophages
Bacteriophages are the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.
5
Biology
Hormones
BBC Radio 4 - In Our Time, Hormones
Hormones, the chemical signals coursing through our bodies throughout our lives, produced in separate areas and spreading via the bloodstream. We call these 'hormones' and we produce more than 80 of them of which the best known are arguably oestrogen, testosterone, adrenalin, insulin and cortisol. On the whole hormones operate without us being immediately conscious of them as their goal is homeostasis, maintaining the levels of everything in the body as required without us having to think about them first. Their actions are vital for our health and wellbeing and influence many different aspects of the way our bodies work.
6
Biology
Plankton
BBC Radio 4 - In Our Time, Plankton
Plancton, the tiny drifting organisms in the oceans that sustain the food chain for all the lifeforms in the water and so for the billions of people who, in turn, depend on the seas for their diet. In Earth's development, the plant-like ones among them, the phytoplankton, produced so much oxygen through photosynthesis that around half the oxygen we breathe today originated there. And each day as the sun rises, the animal ones, the zooplankton, sink to the depths of the seas to avoid predators in such density that they appear on ship sonars like a new seabed, only to rise again at night in the largest migration of life on this planet.
7
Biology
The microscope
BBC Radio 4 - In Our Time, The Microscope
In the seventeenth century the pioneering work of two scientists, the Dutchman Antonie van Leeuwenhoek and Robert Hooke in England, revealed the teeming microscopic world that exists at scales beyond the capabilities of the naked eye. The microscope became an essential component of scientific enquiry by the nineteenth century, but in the 1930s a German physicist, Ernst Ruska, discovered that by using a beam of electrons he could view structures much tinier than was possible using visible light. Today light and electron microscopy are among the most powerful tools at the disposal of modern science, and new techniques are still being developed.
8
Biology
Immunisation
BBC Radio 4 - In Our Time, Immunisation
In 1717, Lady Mary Wortley Montagu, the wife of the British Ambassador to the Ottoman Empire, wrote a letter to her friend describing how she had witnessed the practice of smallpox inoculation in Constantinople. This involved the transfer of material from a smallpox postule into multiple cuts made in a vein. Lady Montagu had lost her brother to smallpox and was amazed that the Middle Eastern practice of inoculation rendered the fatal disease harmless. In Britain, the practice was unknown. Inoculation was an early attempt at creating immunity to disease, but was later dismissed when Edward Jenner pioneered immunisation through vaccination in 1796. Vaccination was hailed a huge success.
9
Biology
Enzymes
BBC Radio 4 - In Our Time, Enzymes
Enzymes, the proteins that control the speed of chemical reactions in living organisms. Without enzymes, these reactions would take place too slowly to keep organisms alive: with their actions as catalysts, changes which might otherwise take millions of years can happen hundreds of times a second. Some enzymes break down large molecules into smaller ones, like the ones in human intestines, while others use small molecules to build up larger, complex ones, such as those that make DNA. Enzymes also help keep cell growth under control, by regulating the time for cells to live and their time to die, and provide a way for cells to communicate with each other.
10
Biology
Mitochondria
BBC Radio 4 - In Our Time, Mitochondria
Inside each cell of every complex organism there are structures known as mitochondria. The 19th century scientists who first observed them thought they were bacteria which had somehow invaded the cells they were studying. We now understand that mitochondria take components from the food we eat and convert them into energy. Mitochondria are essential for complex life, but as the components that run our metabolisms they can also be responsible for a range of diseases – and they probably play a role in how we age. The DNA in mitochondria is only passed down the maternal line. This means it can be used to trace population movements deep into human history, even back to an ancestor we all share: mitochondrial Eve.
11
Biology
Rosalind Franklin
BBC Radio 4 - In Our Time, Rosalind Franklin
During her distinguished career, Franklin carried out ground-breaking research into coal and viruses but she is perhaps best remembered for her investigations in the field of DNA. In 1952 her research generated a famous image that became known as Photograph 51. When the Cambridge scientists Francis Crick and James Watson saw this image, it enabled them the following year to work out that DNA has a double-helix structure, one of the most important discoveries of modern science. Watson, Crick and Franklin's colleague Maurice Wilkins received a Nobel Prize in 1962 for this achievement but Franklin did not and today many people believe that Franklin has not received enough recognition for her work.
12
Biology
Parasitism
BBC Radio 4 - In Our Time, Parasitism
Parasitism, the relationship between parasites and hosts, where one species lives on or in another to the benefit of the parasite but at a cost to the host, potentially leading to disease or death of the host. Typical examples are mistletoe and trees, hookworms and vertebrates, cuckoos and other birds. In many cases the parasite species do so well in or on a particular host that they reproduce much faster and can adapt to changes more efficiently, and it is thought that almost half of all animal species have a parasitic stage in their lifetime. What techniques do hosts have to counter the parasites, and what impact do parasites have on the evolution of their hosts?
13
Biology
Photosynthesis
BBC Radio 4 - In Our Time, Photosynthesis
Photosynthesis, the process by which green plants and many other organisms use sunlight to synthesise organic molecules. Photosynthesis arose very early in evolutionary history and has been a crucial driver of life on Earth. In addition to providing most of the food consumed by organisms on the planet, it is also responsible for maintaining atmospheric oxygen levels, and is thus almost certainly the most important chemical process ever discovered.
14
Biology
Genetic engineering
BBC Radio 4 - In Our Time, Genetic Engineering
Out of the city of Cambridge in the mid century came DNA and out of Edinburgh at the end of the century came the cloning of Dolly the sheep. These two facts might well do more to change the world literally, and our view of the world, than anything else that has happened at any time. Genetics have become the conversation of our day and with the Human Genome Project lumbering towards completion, its power grows. But are the consequences likely to be destructive and will what we think of as a human being, a personality, or even a person, change uncomfortably and irredeemably?
15
Biology
Genetic Mutation
BBC Radio 4 - In Our Time, Genetic Mutation
A mutation is an error in reproduction between one generation and the next as the copying mechanism that allows you to inherit your parent’s genes goes awry. Mutations are almost always bad news for the organism that suffers them and yet mutation is also a giver of life. Without it there would be no natural selection, no evolution and, arguably, no life on this planet. It’s not unreasonable to see life itself as a mutation and to understand this may also hold the key to aging and disease. It is, in the Darwinian view of life, the raw material of evolution.
16
Biology
On the origin of species
BBC Radio 4 - In Our Time, Darwin: In Our Time, Darwin: On the Origin of Species
To celebrate the 200th anniversary of the birth of Charles Darwin and the 150th anniversary of the publication of On the Origin of Species, Melvyn Bragg presents a series about Darwin's life and work. How Darwin was eventually persuaded to publish On the Origin of Species in November 1859 and the book's impact on fellow scientists and the general public.
17
Biology
Evolution
BBC Radio 4 - In Our Time, Evolution
Are we continuing to evolve? If so, what are the signs and if not, why not? And those apes, so very very near us in genetic kinship, why are they so far away in so much else, and will they ever evolve? And is evolution necessarily progression? If so, does our apparent lack of evolution mean lack of progress? Also on the evolutionary front, could electronic devices discover the means of self-replication, and what will that mean for us? The march of the life sciences after the discovery of DNA accelerates by the year but what are the implications?
18
Biology
Fossils
BBC Radio 4 - In Our Time, Fossils
In the middle of the nineteenth century the discoveries of the fossil hunters used to worry poor Ruskin to death, he wrote in a letter in 1851, “my faith, which was never strong, is being beaten to gold leaf…If only those Geologists would let me alone I could do very well, but those dreadful Hammers! I hear the clink of them at the end of every cadence of the Bible verses.”The testimony of fossils over the ages has been remarkably eloquent when we have wanted to listen; and now with mass spectrometers, electron microscopes and secondary X-ray detectors, these long dead organisms can speak to us of the past in ways they never could before.
19
Biology
The late devonian extinction
BBC Radio 4 - In Our Time, The Late Devonian Extinction
The late devonian extinction was the devastating mass extinctions of the Late Devonian Period, roughly 370 million years ago, when around 70 percent of species disappeared. Scientists are still trying to establish exactly what happened, when and why, but this was not as sudden as when an asteroid hits Earth. The Devonian Period had seen the first trees and soils and it had such a diversity of sea life that it’s known as the Age of Fishes, some of them massive and armoured, and, in one of the iconic stages in evolution, some of them moving onto land for the first time. One of the most important theories for the first stage of this extinction is that the new soils washed into oceans, leading to algal blooms that left the waters without oxygen and suffocated the marine life.
20
Biology
The fish-tetrapod transistion
BBC Radio 4 - In Our Time, The Fish-Tetrapod Transition
Around 400 million years ago some of our ancestors, the fish, started to become a little more like humans. At the swampy margins between land and water, some fish were turning their fins into limbs, their swim bladders into lungs and developed necks and eventually they became tetrapods, the group to which we and all animals with backbones and limbs belong. After millions of years of this transition, these tetrapod descendants of fish were now ready to leave the water for a new life of walking on land, and with that came an explosion in the diversity of life on Earth.
21
Biology
Human origins
BBC Radio 4 - In Our Time, Human Origins
The story of human evolution is one that stretches back over five million years, and during that time there are reckoned to have been between fifteen and twenty species of hominid to have walked this planet. From the earliest (Genus) Australopithecus (Species) Anamensis through times when there have been several divergent pre-human species existing at once, we have now arrived at a period unique in the history of the earth when a sole human species, Homo Sapiens, is in evidence right across the globe.
22
Biology
The Neanderthals
BBC Radio 4 - In Our Time, The Neanderthals
In 1856, quarry workers in Germany found bones in a cave which seemed to belong to a bear or other large mammal. They were later identified as being from a previously unknown species of hominid similar to a human. The specimen was named Homo neanderthalis after the valley in which the bones were found.This was the first identified remains of a Neanderthal, a species which inhabited parts of Europe and Central Asia from around 400,000 years ago. Often depicted as little more advanced than apes, Neanderthals were in fact sophisticated, highly-evolved hunters capable of making tools and even jewellery.
23
Biology
Homo Erectus
BBC Radio 4 - In Our Time, Homo erectus
One of our ancestors, Homo erectus, who thrived on Earth for around two million years whereas we, Homo sapiens, emerged only in the last three hundred thousand years. Homo erectus, or Upright Man, spread from Africa to Asia and it was on the Island of Java that fossilised remains were found in 1891 in an expedition led by Dutch scientist Eugène Dubois. Homo erectus people adapted to different habitats, ate varied food, lived in groups, had stamina to outrun their prey; and discoveries have prompted many theories on the relationship between their diet and the size of their brains, on their ability as seafarers, on their creativity and on their ability to speak and otherwise communicate.
24
Biology
Echolocation
BBC Radio 4 - In Our Time, Echolocation
Some bats, dolphins and other animals emit sounds at high frequencies to explore their environments, rather than sight. This was such an unlikely possibility, to natural historians from C18th onwards, that discoveries were met with disbelief even into the C20th; it was assumed that bats found their way in the dark by touch. Not all bats use echolocation, but those that do have a range of frequencies for different purposes and techniques for preventing themselves becoming deafened by their own sounds. Some prey have evolved ways of detecting when bats are emitting high frequencies in their direction, and some fish have adapted to detect the sounds dolphins use to find them.