Research & Supervision

Abstract

Rapid shallow breathing resulting in human subjects acclimates to large inspiratory resistance that is characteristics to central respiratory muscle fatigue (RMF). RMF is difficult to measure because there are several factors are contributed to limit accurate measurement of RMF. Hence, the purpose of this dissertation was to present a design of a novel of protocol to investigate RMF and will potentially be useful for clinical population. RMF was conducted in healthy individuals with different physiological activities levels and Obstructive sleep apnoea (OSA) patients. 63 healthy individual participants conducted, and 26 (OSA) patients were recruited from hospital in Bangor and subjects were tested in two occasions. A self-reported long-version last seven days (IPAQ) was used to classify levels of fitness. Body characteristics, lung function volume, and maximal in inspiratory pressure IPmax, PowerBreathing resistance were included in order to perform this method and measuring RMF as a proxy measure in the study. Results: the test of inspiratory muscle pressure that matched the (RPE) of rate 14 no significant differences was found in slopes between fatigue and non-fatigue [t (61) = 8.046, P = 0.000]. Level of fitness between group of fitness (Normal and overweight healthy individual were significant in IP14 at 20 breaths [P = 0.025; at 40 breaths P = 0.033; at 60 breaths P = 0.035]. BMI had an impact on pressure with significant negative correlation across all trails in IP14. Significant effect was found in IP14 between overweight healthy individual group and OSA patient was significant in IP14.at 60, 80 and 100 [P = 0.008; P = 0.045; P = 0.028]. The data showed that significant difference was found between OSA severities in IP14 at 60 breaths [P = 0.015]. Very high repeatability was found between test and retest of the protocol. It can be concluded that increasing BMI has a negative effect on the increasing pressure of breathing.