The Mono Project

Epstein-Barr Virus Diseases Research

Our Research

Our research mission is to learn how Epstein-Barr virus (EBV) causes disease and to develop a vaccine against it.

Epstein-Barr virus (EBV) infects at least 90% of the adult population worldwide and is the primary cause of infectious mononucleosis. EBV is also the cause or the major risk factor for several forms of cancer, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma. EBV is also the leading cause of posttransplant lymphoproliferative disorder in solid organ and hematopoietic cell (bone marrow) transplant patients. Additionally, new research strengthens the evidence that EBV is involved in the pathogenesis of multiple sclerosis.

Epstein-Barr Virus Vaccine

Our hypothesis is that a prophylactic EBV vaccine could prevent or reduce the severity of all EBV-associated illnesses. Researchers at the Mono Project are actively collaborating with researchers at the NIH to perform clinical trials of candidate EBV vaccines.

Chronic Mono

Chronic mono follows an EBV infection with two patterns, including continuous illness persisting after the onset or recovery from the acute illness but lingering or recurring symptoms for years. For advice on managing chronic mono click here to download our treatment suggestions for antiviral drugs and diet. All treatments should be followed under the direct supervision of a physician.

Watch an Interview with Dr. Balfour


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