PUBLICATIONS

Pletcher lab member in bold

Pletcher Undergrads are in bold

Christi M. Gendron, Tuhin S. Chakraborty, Cathryn Duran, Thomas Dono, Scott D. Pletcher

June 13, 2023, Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging, PLOS, https://doi.org/10.1371/journal.pbio.3002149 

 
K.J. Weaver, R.A. Holt, E. Henry, Y. Lyu, S.D. Pletcher,  

May 12, 2023, Effects of hunger on neuronal histone modifications slow aging in Drosophila Science, Volume 380, Issue 6645, https://doi.org/10.1126/science.ade1662 

Jacob C. Johnson1 , Allyson S. Munneke2 , Haley M. Richardson1 , Christi M. Gendron1,3 , Scott D. Pletcher1,3

January 6, 2023, Light modulates Drosophila lifespan via perceptual systems independent of circadian rhythms, Aging2023; https://doi.org/10.18632/aging.204472 

Yang Lyu, Kristina J Weaver, Humza A Shaukat, Marta L Plumoff, Maria Tjilos, Daniel EL Promislow, Scott D Pletcher.

January 19, 2021, Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice, eLife 2021;10:e59399 DOI: 10.7554/eLife.59399 

Chakraborty TS1, Gendron CM1, Lyu Y1, Munneke AS2, DeMarco MN1, Hoisington ZW1, Pletcher SD3,4.

May 30, 2019.  Sensory perception of dead conspecifics induces aversive cues and modulates lifespan through serotonin in Drosophila. Nat Commun. 2019 May 30;10(1):2365. doi: 10.1038/s41467-019-10285-y.

Brandon C. Shell1, Rebecca E. Schmitt1,2, Kristen M. Lee1,3, Jacob C. Johnson4, Brian Y. Chung 4, Scott D. Pletcher4 & Mike Grotewiel1,2,3,5. Aug 1, 2018. Measurement of solid food intake in Drosophila via consumption/excretion of a dye tracer. Published online. doi: 10.1038/s41598-018-29813-9Sci Rep. 2018; 8: 11536.

Gendron CM1, Pletcher SD1. December, 2017. MicroRNAs mir-184 and let-7 alter Drosophila metabolism and longevity. Aging Cell. 2017 Dec;16(6):1434-1438. doi: 10.1111/acel.12673. Epub 2017 Sep 29.

Pickering AM1,2,3, Lehr M2,3, Gendron CM3,4, Pletcher SD3,4, Miller RA2,3. August 16, 2017.Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.

Aging Cell. 2017 Aug;16(4):683-692. doi: 10.1111/acel.12596. Epub 2017 May 5.

Harvanek ZM1,2, Lyu Y1, Gendron CM1, Johnson JC1, Kondo S3, Promislow DEL4,5, Pletcher SD1,6. May 15,2017. Perceptive costs of reproduction drive ageing and physiology in male Drosophila. Nat Ecol Evol. 2017 May 15;1(6):152. doi: 10.1038/s41559-017-0152

Devin Arbuthnott, Tatyana Y. Fedina, Scott D. Pletcher & Daniel E. L. Promislow. 2017. Mate choice in fruit flies is rational and adaptive. Nature Communicationsvolume 8, Article number: 13953

Zachary M. Harvanek, Yang Lyu, Christi M. Gendron, Jacob C. Johnson, Shu Kondo, Daniel E. L. Promislow & Scott D. Pletcher. 2017. Perceptive costs of reproduction drive ageing and physiology in male Drosophila. Nature Ecology & Evolution volume 1, Article number: 0152

Andrew M. Pickering, Marcus Lehr, Christi M. Gendron. Scott D. Pletcher, Richard A. Miller.

05 May 2017. Mitochondrial thioredoxin reductase 2 is elevated in long‐lived primate as well as rodent species and extends fly mean lifespan.https://doi.org/10.1111/acel.12596

Ro J, Pak G, Maler PA, Lau Y, Allison DB, Kennedy RT, Pletcher SD. 2016. Serotonin signaling mediates protein valuation and aging. eLife. e16843. DOI: 10.7554/eLife16843.

Waterson MJ, Chan TP, Pletcher SD. 2015. Adaptive Physiological Response to Perceived Scarcity as a Mechanism of Sensory Modulation of Life Span. Journal of Gerontology: Biological Sciences. [ePub ahead of print]. (LINK) (PUBMED)

Linford NJ, Ro J, Chung BY, Pletcher SD. 2015. Gustatory and metabolic perception of nutrient stress in Drosophila. PNAS. 112(8):2587-92. (LINK) (PUBMED)

Ro J, Harvanek ZM, Pletcher SD. 2014. FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila. PloS One. 9(6):e101107. (LINK) (PUBMED)

Ostojic I, Boll W, Waterson MJ, Chan T, Chandra R, Pletcher SD, Alcedo J. 2014. Positive and negative gustotary inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. PNAS. 111(22):8143-8. (Link) (Pubmed)

Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD. 2014. Water sensor ppk228 modulates Drosophila lifespan and physiology through AKH signaling. PNAS. 111(22):8137-42. (PDF) (Pubmed)

C.M. Gendron, T.H. Kuo, Z.M. Harvanek, B.Y. Chung, J.Y. Yew, H.A. Dierick and S. D. Pletcher. 2013. Drosophila life span and physiology are modulated by sexual perception and reward. Science. DOI: 10.1126/science.1243339 . (Link) (Pubmed)

N. J. Linford, C. Bilgir, J. Ro and S. D. Pletcher. 2013. Measurement of lifespan in Drosophila melanogaster. Journal of Visualized Experiments. (71) (Link) (Pubmed)

T. Y. Fedina, T.H. Kuo, K. Dreisewerd, H.A. Dierick, J.Y. Jew, S. D. Pletcher. 2012. Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. PLoS Genet. 8(5):e1002668. (PDF) (Pubmed)

N. J. Linford, T.P. Chan, S. D. Pletcher. 2012. Dietery effects on cuticular hydrocarbons and sexual attractiveness in Drosophila. PLoS One. 7(12):e49799. (PDF) (Pubmed)

T.H. Kuo, T.Y. Fedina, I. Hansen, K. Dreisewerd, H.A. Dierick, J.Y. Jew, S. D. Pletcher. 2012. Insulin signaling mediates sexual attractiveness in Drosophila. PLoS Genetics. 8(4):e1002684. (PDF) (Pubmed)

T.H. Kuo, J.Y. Jew, T.Y. Fedina, K. Dreisewerd, H.A. Dierick, S. D. Pletcher. 2012. Aging modulates cuticular hydrocarbons and sexual attractiveness in Drosophila melanogaster. Journal of Experimental Biology. 215, 814-821. (PDF) (Pubmed)

H. Kabil, O. Kabil, R. Banerjee, L.G. Harshman, S. D. Pletcher. 2011. Increased transsulferation mediates longevity and dietary restriction in Drosophila. PNAS. 108(40):16831-6. (PDF) (Pubmed)

N. J. Linford, T.H. Kuo, T.P. Chan, S. D. Pletcher. 2011. Sensory perception and aging in model systems: from the outside in. Annual Reviews Cell and Deveopmental Biology. 27:759-85. (PDF) (Pubmed)

Poon, P., T-H. Kuo, N. J. Linford, G. Roman, and S. D. Pletcher. 2010. Carbon dioxide sensing modulates lifespan and physiology in Drosophila. PLoS Biol. 8(4):e1000356. (PDF) (Pubmed)

D. Skorupa, A. Dervisefendic, D. J. Zwiener, S. D. Pletcher. 2008. Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell. 7(4):478-490. PMCID: PMC2574586 (PDF) (Pubmed)

Libert, S. and S. D. Pletcher. 2007. Modulation of longevity by environmental sensing. Cell. 131:1231-1234. (PDF) (Pubmed)

Libert, S. J. Zwiener, X. Chu, W. VanVoorhies, G. Roman, S. D. Pletcher. 2007. Regulation of Drosophila lifespan by olfaction and food-derived odors. Science. 315:1133-1137. (PDF) (Pubmed)

Pletcher, S. D., H. Kabil, L. Partridge. 2007. Chemical complexity and the genetics of aging. Annual Review of Ecology, Evolution, and Systematics. 38: 299-326. (PDF)

Libert, S. Y Chao, X. Chu, and S.D. Pletcher. 2006. Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkB signaling. Aging Cell. 5: 533-43. (PDF)

McCarroll S. A., C. T. Murphy, S. G. Zou, S. D. Pletcher, et al. 2004. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics. 36: 197-204. (PDF) (Pubmed)

Mair, W., P. Goymer, S. D. Pletcher and L. Partridge. 2003. Demography of dietary restriction and death in Drosophila. Science. 301:1731-1733. (PDF) (Pubmed)

Pletcher, S. D., S. J. Macdonald, R. Marguirie, U. Certa, S. C. Stearns, D. B. Goldstein, and L. Partridge. 2002. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Current Biology 12:712-723. (PDF) (Pubmed)

Pletcher, S. D., A. Khazaeli, and J. W. Curtsinger. 2000. Why do lifespans differ? Partitioning mean longevity differences in terms of age-specific mortality parameters. Journal of Gerontology: Biological Sciences. 55(8): B381-B389 (Pubmed)

Fabrizio, P, F. Pozza, S. D. Pletcher, C. M. Gendron, V. D. Longo. 2001. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 292: 288-290 (Pubmed)

Pletcher, S. D. 1999. Model fitting and hypothesis testing for age-specific mortality data. Journal of Evolutionary Biology. 12:314-328 (PDF) 

Pletcher, S. D., and C. J. Geyer. 1999. The genetic analysis of age-dependent traits: Modeling a character process. Genetics. 153: 825-833. (PDF) (Pubmed)

Pletcher, S. D., D. Houle, and J. W. Curtsinger. 1998. Age-specific properties of spontaneous mutations affecting mortality in Drosophila melanogaster. Genetics. 148:287-303. (PDF) (Pubmed) 

SELECTED COMMENTARIES/OPINIONS

D.B. Lombard, S. D. Pletcher, C. Canto, J. Auwerx. 2011. Ageing: Longevity hits a roadblock. Nature. 477, 410-411 (PDF) (Pubmed) 

Linford, N. J. and S. D. Pletcher. 2009. Aging: Fruit flies break the chain to live a longer life: Current Biology. 19(19):R895-8. (PDF) (Pubmed) 

Poon, P.C. and S.D. Pletcher. 2007. Choreographing the fly’s danse macabre. Cell Metabolism. 6:91-93. (PDF) (Pubmed) 

Pletcher, S. D. 2004. Vital connections. Science, SAGE KE. (19). (Link) (Pubmed) 

Pletcher, S. D. 2002. Mitigating the Tithonus error: Genetic analysis of mortality phenotypes. Science SAGE KE. (37). (Link) (Pubmed) 

Pletcher, S. D. and M. Stumpf. 2002. Aging by association. Current Biology. 12:R328-R330. (PDF)