Selected Publications (in chronological order)

Chukkapalli, V, I.B. Hogue, V. Boyko, W.-S. Hu, and A. Ono* 2008. Interaction between HIV-1 Gag matrix domain and phosphatidylinositol-(4.5)-bisphosphate is essential for efficient Gag-membrane binding. J. Virol. 82:2405-2417.

Ono, A.* 2009. HIV-1 assembly at the plasma membrane: Gag trafficking and localization. Future Virology. 4:241-257. (review)

Hogue, I.B., A. Hoppe, and A. Ono* 2009. Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-Gag interaction: relative contributions of the CA and NC domains and membrane binding. J Virol. 83:7322-7336.

Chukkapalli, V., S.J. Oh and A. Ono* 2010. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain. Proc. Natl. Acad. Sci. USA. 107:1600-1605.

Ono, A.* 2010.Relationships between plasma membrane microdomains and HIV-1 assembly. Biol. Cell. 102:335-50. (review) 

Llewellyn, G.N., I.B. Hogue, J.R. Grover, and A. Ono* 2010. Nucleocapsid promotes localization of HIV-1 Gag to uropods that participate in virological synapses between T cells.  PLoS Pathogens 6:e1001167.

Monde, K., V. Chukkapalli, and A. Ono* 2011. Assembly and Replication of HIV-1 in T Cells with Low Levels of Phosphatidylinositol-(4,5)-Bisphosphate. J Virol. 85:3584-3595.

Inlora, J., V. Chukkapalli, D. Derse, and A. Ono* 2011. Gag Localization and Virus-Like Particle Release Mediated by the Matrix Domain of Human T-Lymphotropic Virus Type 1 Gag Are Less Dependent on Phosphatidylinositol-(4,5)-Bisphosphate than Those Mediated by the Matrix Domain of HIV-1 Gag. J Virol. 85:3584-3595.

Chukkapalli, V.  and A. Ono* 2011. Molecular determinants that regulate plasma membrane association of HIV-1 Gag. J.Mol.Biol. 410:512-524. (review)

Hogue, I.B., J.R. Grover, F. Soheilian, K. Nagashima, and A. Ono* 2011. Gag Induces the Coalescence of Clustered Lipid Rafts and Tetraspanin-Enriched Microdomains at HIV-1 Assembly Sites on the Plasma Membrane. J Virol. 85:9749-9766.

Hogue, I.B.#, G.N. Llewellyn#, and A. Ono* 2012. Dynamic Association between HIV-1 Gag and Membrane Domains. Mol.Biol.Int. 2012:979765. (review)

Monde, K., R. Contreras-Galindo, M.H. Kaplan, D.M. Markovitz, and A. Ono* 2012. HERV-K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1. J Virol.  86: 11194-11208.

Grover, J.R., G.N. Llewellyn, F. Soheilian, K. Nagashima, S.L. Veatch*, and A. Ono* 2013. Roles Played by Capsid-Dependent Induction of Membrane Curvature and Gag-ESCRT Interactions in Tetherin Recruitment to HIV-1 Assembly Sites. J. Virol. 87: 4650-4664.

Llewellyn, G.N., J.R. Grover, B. Olety, and A. Ono* 2013. HIV-1 Gag Associates with Specific Uropod-Directed Microdomains in a Manner Dependent on its MA Highly Basic Region. J. Virol. 87: 6441-6454.

Chukkapalli, V.#, J. Inlora#, G. C. Todd, and A. Ono* 2013. Evidence in support of RNA-mediated inhibition of phosphatidylserine-dependent HIV-1 Gag membrane binding in cells. J. Virol. 87: 7155-7159.

Olety, B. and A. Ono.* 2014. Roles played by acidic lipids in HIV-1 Gag membrane binding. Virus Research 2014 193:108-115. (review) 

Inlora, J., D.R. Collins, M.E. Trubin, J.Y. Chung, and A. Ono.* 2014. Membrane binding and subcellular localization of retroviral Gag proteins are differentially regulated by MA interactions with phosphatidylinositol-(4,5)-bisphosphate and RNA. MBio. 5:e02202 

Grover, J.R., S.L. Veatch,* and A. Ono.* 2015. Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles. J. Virol. 89:454-467.

Olety, B., S.L. Veatch, and A. Ono.* 2015. Phosphatidylinositol-(4,5)-Bisphosphate Acyl Chains Differentiate Membrane Binding of HIV-1 Gag from That of the Phospholipase Cδ1 Pleckstrin Homology Domain. J. Virol. 89:7861-7873.

Inlora, J., V. Chukkapalli, S. Bedi, and A. Ono.* 2016. Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages. J. Virol. 90:8509-8519.

Todd, G.C., A. Duchon, J. Inlora, E.D. Olson, K. Musier-Forsyth, and A. Ono.*  2017. Inhibition of HIV-1 Gag-membrane interactions by specific RNAs. RNA 23: 395-405.

Murakami, T., Kim, J., Li, Y., Green, G.E., Shikanov, A., and A. Ono.* 2018. Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nature Commun. 9: 2436.

Bedi, S., T.  Noda, Y. Kawaoka, and A. Ono.* 2018. A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages. MBio. 9:e01916 

Bedi, S. and A. Ono.* 2019. Friend or Foe: The Role of the Cytoskeleton in Influenza A Virus Assembly. Viruses. 11:E46 (review)

Thornhill, D., B. Olety, and A. Ono.* 2019. Relationships between MA-RNA binding in cells and suppression of HIV-1 Gag mislocalization to intracellular membranes. J. Virol. DOI: 10.1128/JVI.00756-19

Murakami, T.,  Carmona, N., and A. Ono.* 2020. Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding. Proc. Natl. Acad. Sci. USA. 117:8055-8063.

Thornhill, D., Murakami, T., and A. Ono.* 2020. Rendezvous at Plasma Membrane: Cellular Lipids and tRNA Set up Sites of HIV-1 Particle Assembly and Incorporation of Host Transmembrane Proteins. Viruses. DOI: 10.3390/v12080842 (review) 

Murakami, T.*  and A. Ono. 2021. HIV-1 entry: Duels between Env and host antiviral transmembrane proteins on the surface of virus particles. Curr. Op. Virol. DOI: 10.1016/j.coviro.2021.07.005 (review)

Sumner, C., Kotani, O., Liu, S., Musier-Forsyth ,K., Sato, H., and A. Ono.* 2021. Molecular determinants in tRNA D-arm required for inhibition of HIV-1 Gag membrane binding. J. Mol. Biol. DOI: 10.1016/j.jmb.2021.167390

Bedi S, Mudgal R, Haag A, and A. Ono A.* 2022. A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages. J Virol. Sep 28;96(18):e0071622. doi: 10.1128/jvi.00716-22.

de Souza Cardoso R, Murakami T, Jacobovitz B, Veatch SL, Ono A.* PIP2 promotes the incorporation of CD43, PSGL-1, and CD44 into nascent HIV-1 particles. Sci Adv. 2025 Apr 4;11(14):eads9711. doi: 10.1126/sciadv.ads9711. Epub 2025 Apr 4. PMID: 40184445; PMCID: PMC11970457.

* corresponding author(s)

# equal contributions

Lab members shown in bold