Assembling HIV-1 particles accumulate in an internal compartment known as VCC in macrophages, a natural host of HIV-1. However, the mechanism promoting this localization is poorly understood. We showed that Gag multimerization is essential for specific localization of Gag to VCC. The image shows that a multimerization-defective Gag derivative (green) is present both in intracellular structures (including VCC; cyan) and the cell surface (red)

(Inlora, Chukkapalli, Bedi, and Ono. 2016)