Publications


Recent Publications (from >100)

McGovern, O.L. and Carruthers, V.B. (2016) Toxoplasma retromer is here to stay. Spotlight article for Trends. Parasitol. S1471-4922(16)30053-8.

Pszenny, V., Ehrenman, K., Romano, J.D., Schultz, A.J., Roos, D.S., Grigg, M.E., Carruthers, V.B., Coppens, I. (2016) A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress. J. Biol. Chem. 291;3725-3746. 

Huynh, M.-Y., Carruthers, V.B. (2016) A Toxoplasma gondii ortholog of Plasmodium GAMA contributes to parasite attachment and cell invasion. mSphere Feb 10;1(1). pii: e00012-16. 

Bullen, H., Jia, Y., Yamaryo-Botte, Y., Zhang, O., Jemelin, N.K., Carruthers, V.B., Botte, C., Soldati-Favre, D. (2016) Phosphatidic acid-mediated signaling is essential for microneme secretion in Toxoplasma. Cell Host Microbe 19(3):349-60. 

Xiao, J., Li, Y., Gressitt, K.L., He, H., Kannan, G., Schultz, T.L., Svezhova, N., Carruthers, V.B., Pletnikov, M.V., Yolken, R.H., Severance, E.G. (2016) Cerebral complement C1q activation in chronic Toxoplasma infection. Brains Behav Immun Apr 22. pii: S0889-1591(16)30100-3. 

Vidadala, R.S.R., Rivas, K.L., Ojo, K.K., Hulverson, M.A., Zambriski, J.A., Bruzual, I., Schultz, T.L., Huang, W., Zhang, Z., Scheele, S., DeRocher, A.E., Choi, R., Barrett, L.K., Siddaramaiah,  L.K., Hol, W.G.J., Fan, E., Merritt, E.A., Parsons, M., Freiberg, G., Marsh, K., Kempf, D., Carruthers, V.B., Isoherranen, N., Doggett, J.S., Van Voorhis, W.C., Maly, D.J. (2016) Development of an Orally Available and CNS-Penetrant TgCDPK1 Inhibitor with Minimal hERG Activity for the Treatment of Toxoplasmosis. J Med Chem. 59(13)6531-6546.

Sidik, S.M., Huet, D., Ganesan, S., Huynh, M.H., Wang, T., Nasamu, A.S., Thiru, P., Saeij, J.P.J., Carruthers, V.B., Niles, J.C., Lourido. S. (2016) A Genome-Wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Cell 166(6):1423-1435. (PMC5017925). Highlighted in “This Week in Parasitology” (TWIP), MedIndia, GenomeWeb; cited as “exceptional” in “Faculty of 1000”.

Guerra, A.J., Carruthers, V.B. (2017) Structural features of apicomplexan pore-forming proteins and their roles in parasite cell traversal and egress. Toxins (Basel). Aug 29;9(9). [Cover illustration][“Editor’s Choice” article]

Di Cristina, M., Dou, Z., Lunghi, M., Kannan, G., Huynh, M.-H., McGovern, O.L., Schultz, A.J., Miller, A.J., Hayes, B.M., van der Linden, W., Emiliani, C., Bogyo, M., Besteiro, S., Coppens, I., Carruthers, V.B. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nature Microbiology [Highlighted in BioCentury, Phys.Org, Futurity, El Medico Interactivo, sumedico.com. and four other news outlets]. [Cited in “Faculty of 1000”].

Di Cristina, M. and Carruthers, V.B. (2018) New and emerging uses of CRISPR/Cas9 to genetically manipulate apicomplexan parasites. Parasitology, 21:1-8. [selected as the journal’s “Paper of the Month”][Highlighted in a Cambridge Core Blogpost]

 

McGovern, O.L., Rivera-Cuevas, Y., Kannan, G., Narwold, A., Carruthers, V.B. (2018) Trafficking of ingested proteins and microneme proteins intersect in Toxoplasma gondiiTraffic.19:336-353.

 

Zwicker, J.D., Diaz, N.A., Guerra A.J., Kirchhoff, P.D., Wen B., Sun, D., Carruthers, V.B., Larson, S.D. (2018) Optimization of dipeptide inhibitors of cathepsin L for Toxoplasma gondiiselectivity and CNS permeability. Biorg Med Chem Lett. 28:1972-1980. (PMC in process)

Guerra, A.J., Zhang, O., Bahr, C.M.E., Huynh, M.H., DelProposto, J., Brown, W.C., Wawrzak, Z., Koropatkin, N.M., Carruthers, V.B. (2018) Structural basis of Toxoplasma gondii perforin-like protein 1 membrane insertion and activity during egress. PLoS Pathogens Dec 4:14(2):e1007476. (PMC in process).

Khurana, S., Coffey, M.J., John, A., Uboli, A., Huynh, M.H., Stewart, R.J., Carruthers, V.B., Tonkin, C.J., Goddard-Borger, E.D., Scott, N.E. (2019) POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites. J Biol Chem (in press)(PMC in process).

Mayoral, J., Di Cristina, M., Carruthers, V.B., Weiss, L.M. (2019) Culturing Toxoplasma bradyzoites. Methods in Molecular Biology (in press).

Piro, F., Carruthers, V.B., Di Cristina, M. (2019) PCR screening of Toxoplasma gondii single clones directly from 96-well plates without DNA purification. Methods in Molecular Biology (in press).

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