The Matrisome Project is an effort initiated by Dr. Naba during her postdoctoral training in the laboratory of Dr. Richard Hynes at MIT, in collaboration with members of the Bioinformatics & Computing Facility at the Koch Institute for Integrative Cancer Research at MIT, and Karl Clauser and Steve Carr at the Proteomics Platform of the Broad Institute.

The Matrisome Project is an open access platform which aims to support and facilitate ECM research by sharing detailed protocols, tools and datasets with the scientific community.

Recent development include the publication of the first draft of an ECM Atlas, compiling proteomic data on the ECM of 14 different tissues and tumors (Naba et al., Matrix Biology, 2016), and the deployment of MatrisomeDB, a searchable database that provide live cross-referencing to gene and protein databases for every ECM and ECM-associated genes and integrates experimental data of the ECM atlas.