Recent 5 years (*corresponding author)
Lee YH, Kuo CJ, Ton NNB, Le CCT, Wu HY, Chiu CH, Lai CH*. Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis. Cell Communication and Signaling. 2026;doi:10.1186/s12964-026-03193-4
Chen H, El-Deeb IM, Lai CH, Huang YT, Poole J, Hartley-Tassell LE, von Itzstein M, Jennings MP, Jen FEC*. Ionophore PBT2 as a novel approach to combat antibiotic-resistant Helicobacter pylori. mBio. 2026;17(7):e0122926.
Huang HY, Huang YY, Wu CL, Huang WC, Lai CH*. Smog, sugar, and synapses: Unraveling the PM2.5-insulin resistance-Alzheimer's disease axis. Redox Biology. 2026;90:104031.
Kuo CJ, Hsu TS, Hsu CM, Wu HY, Chen CL, Le PH, Chiang-Ni C, Chen YM, Chiu CH, Lai CH*. Vancomycin-resistant gut commensal Clostridium innocuum emerges as a pathobiont through synergy with toxigenic Clostridioides difficile. Microbial Pathogenesis. 2026;216:108531.
Lien HM, Wang YY, Li SW, Lin HJ, Wu HY, Huang YT, Chen CY, Chen CC, Chiu CH, Lai CH*. Anisomeles indica enriched with ovatodiolide protects against aspirin-induced gastric ulcers through gut microbiota modulation. Biomedical Journal. 2026:49(2):100893.
Hung CL, Hsu WN, Wang TC, Chen WR, Chen YT, Kuo ZK, Hu TL, Lin YC, Yeh HH, Lin HC, Yu CJ, Fu CW, Liu HH, Hsu HC, Lin PH, Pang ST, Lai CH, Wang LY*. Oral bioavailable ITRI-148 degrades androgen receptor variants and overcomes antiandrogen resistance in advanced prostate cancer. Neoplasia. 2026;71:101253.
Lai CH*, Wu SY, Li SW, Ho QNU, Chiang RL, Bui NN, Wu HY. Huang YT, Chiu CH, Wang WC*. Region-specific genomic variation and functional divergence of Helicobacter pylori clinical isolates from the gastric antrum and corpus. mSystems. 2025;22;10(10):e0102925.
Chang KW, Chen JT, Chuang CN, Thao DTT, Huang YT, Wu HY, Kuo ML, Kao KC, Chiu CH, Lai CH*. Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis. Journal of Hazardous Materials. 2025;497:139696.
Bui NN, Huang SC, Le Tran TN, Nguyen NH, Do HN, Chiu YF, Lai CH*. Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis. QJM-An International Journal of Medicine. 2025;118(8):584-591.
Que AT, Tran AD, Trang THN, Tran TNL, Bui NN, Lai CH*. Epidemiology and antimicrobial resistance patterns of urinary tract infection: insights and strategies from a 5-year serial cross-sectional study in Vietnam. Ther Adv Infect Dis. 2025;12:20499361251315346.
Chou LF, Liu YC, Yang HY, Tian YC, Lai CH, Chang MY, Hung CC, Wang TH, Hsu SH, Tsai CY, Hung PY, Yang CW*. Uncovering latent infections in kidneys: A novel molecular approach for differential Leptospira detection. Curr Res Microb Sci. 2025;26(8):100327.
Liao WC, Chou CH, Ho MW, Chen JT, Chou SL, Huang YT, Bui NN, Wu HY, Lee CF, Huang WC, Lai CH*. Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection. J Microbiol Immunol Infect. 2025;58(1):120-127.
Kao WH, Chiu KY, Tsai SC, Teng CJ, Oner M, Lai CH, Hsieh JT, Lin CC, Wang HY, Chen MC, Lin H*. PI3K/Akt inhibition promotes AR activity and prostate cancer cell proliferation through p35-CDK5 modulation Biochim Biophys Acta Mol Basis Dis. 2025;1871(2):167568.
Yeh JA, Huang HK, Chou AL, Lin HJ, Feng CL, Kuo CJ, Lai CH*. Helicobacter pylori eradication with high-dose proton pump inhibitor-amoxicillin dual therapy: A systematic review and meta-analysis. Int J Antimicrob Agents. 2024;63(6):107159.
Ma J†, Chiu YF†, Kao CC, Chuang CN, Chen CY, Lai CH†, Kuo ML*. Fine particulate matter manipulates immune response to exacerbate microbial pathogenesis in the respiratory tract. Eur Respir Rev. 2024;33(173):230259. (†equal contribution)
Chang YF, Huang YP, Chou CH, Ho MW, Lin HJ, Chen CY, Wu HY, Lai YR, Lee YH, Chiu CH, Lai CH*. RAGE participates in the intracellular transport of Campylobacter jejuni cytolethal distending toxin. J Microbiol Immunol Infect. 2024;57(5):709-719.
Kao WH, Liao LZ, Chen YA, Lo UG, Pong RC, Hernandez E, Chen MC, Teng CJ, Wang HY, Tsai SC, Kapur P, Lai CH, Hsieh JT, Lin H*. SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade. Cell Death Dis. 2024;15(9):678.
Ho SM†, Tsai WH†, Lai CH†, Chiang MH, Lee WP, Wu HY, Bai PY, Wu T, Wu CL*. Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. Gut Microbes. 2024;16(1):2316533. (†equal contribution)
Li YJ, Chen CY, Kuo YS, Huang YW, Kuo RL, Chang LK, Yang JH, Lai CH, Shih SR, Chiu YF*. OTUB1 contributes to the stability and function of Influenza A virus NS2. PLoS Pathog. 2024;20(5):e1012279.
Huang HL, Lai CH, Tsai WH, Chen KW, Peng SL, Lin JH, Lin YH*. Nanoparticle-enhanced postbiotics: Revolutionizing cancer therapy through effective delivery. Life Sci. 2024;337:122379.
Kuo CJ, Bui NN, Ke JN, Lin CY, Lin WR, Chang ML, Wu HY, Huang MZ, Chiu CH, Chiu CT, Lai CH*. Molecular characterization of rifabutin-resistance in refractory Helicobacter pylori infection in Taiwan. Int J Infect Dis. 2023;138:25-28.
Bui NN, Li CY, Wang LY, Chen YA, Kao WH, Chou LF, Hsieh JT, Lin H, Lai CH*. Clostridium scindens metabolites trigger prostate cancer progression through androgen receptor signaling. J Microbiol Immunol Infect. 2023;56(2):246-256.
Wu HY, Kuo CJ, Chou CH, Ho MW, Chen CL, Hsu TS, Chen YC, Chiang-Ni C, Chen YM, Chiu CH, Lai CH*. Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity. Virulence. 2023;14(1):2265048.
Kuo CJ, Ke JN, Kuo T, Lin CY, Hsieh SY, Chiu YF, Wu HY, Bui NN, Chiu CH, Chiu CT, Lai CH*. Multiple amino acid substitutions in penicillin-binding protein-1A confer amoxicillin resistance in refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2023;56(1):40-47.
Lai CH*, Lin TL, Huang MZ, Li SW, Wu HY, Chiu YF, Yang CY, Chiu CH, Lai HC*. Gut commensal Parabacteroides goldsteinii MTS01 Alters gut microbiota composition and reduces cholesterol to mitigate Helicobacter pylori-induced pathogenesis. Front Immunol. 2022;13(916848):1-13.
Chou LF, Chen TW, Yang HY, Tian YC, Chang MY, Hung CC, Lai CH, Hsu SH, Tsai CY, Ko YC, Lian JH, Yang CW*. Implication of the IL-10-expression signature in the pathogenicity of Leptospira-infected macrophages. Microbiol Spectr. 2022;10(3):e0259521.
Lo UG, Chen YA, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai CH, Mu P, Chung LWK, Hsieh JT*. The driver role of JAK-STAT signaling in cancer stemness capabilities leading to new therapeutic strategies for therapy- and castration-resistant prostate cancer. Clin Transl Med. 2022;12(8):e978.
Chiang MH, Ho SM, Wu HY, Lin YC, Tsai WH, Wu T, Lai CH*, Wu CL*. Drosophila model for studying gut microbiota in behaviors and neurodegenerative diseases. Biomedicines. 2022;10(3):596.
Lee CF, Chen YA, Hernandez E, Pong RC, Ma S, Hofstad M, Kapur P, Zhau H, Chung LW, Lai CH, Lin H, Lee MS, Raj GV, Hsieh JT*. The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC. Clin Transl Med. 2022;12(2):e695.
Hsu CY, Yeh JY, Chen CY, Wu HY, Chiang MH, Wu CL, Lin HJ, Chiu CH, Lai CH*. Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells. Virulence. 2021;12(1): 2341-2351.
Gagliardi MC, Iwabuchi K, Lai CH*. Editorial: Role of lipid rafts in anti-microbial immune response. Front Immunol. 2021;12:1-2.
Kuo CJ, Lee CH, Chang ML, Lin CY, Lin WR, Su MY, Chiu CH, Tseng CN, Wu YS, Chiu CT, Lai CH*. Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection. J Microbiol Immunol Infect. 2021;54(6):1184-1187.
Lin TY, Lan WH, Chiu YF, Feng CL, Chiu CH, Kuo CJ, Lai CH*. Statins' regulation of the virulence factors of Helicobacter pylori and the production of ROS may inhibit the development of gastric cancer. Antioxidants. 2021;10(8): 1-14.
Yeh JY, Lin HJ, Kuo CJ, Feng CL, Chou CH, Lin CD, Wu HY, Li CY, Chiu CH, Lai CH*. Campylobacter jejuni cytolethal distending toxin C exploits lipid rafts to mitigate Helicobacter pylori-induced pathogenesis. Front Cell Dev Biol. 2021;8:1-10.
Chen YA, Lai YR, Wu HY, Lo YJ, Chang YF, Hung CL, Lin CJ, Lo UG, Lin H, Hsieh JT, Chiu CH, Lin YH, Lai CH*. Bacterial genotoxin-coated nanoparticles for radiotherapy sensitization in prostate cancer. Biomedicines. 2021;9(2):1-15.
Tsou YA, Chang WC, Lin CD, Chang RL, Tsai MH, Shih LC, Staniczek T, Wu TF, Hsu HY, Chang WD, Lai CH*, Chen CM*. Metformin increases survival in hypopharyngeal cancer patients with diabetes mellitus: retrospective cohort study and cell-based analysis. Pharmaceuticals. 2021;26;14(3):1-16.
Sit WY, Chen YA, Chen YL, Lai CH*, Wang WC*. Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate. Seminars in Cell & Developmental Biology. 2020;101:59-67.
Chen YW, Li SW, Lin CD, Huang MZ, Lin, HJ, Chin CY, Lai YR, Chiu CH, Yang CY, Lai CH*. Fine particulate matter exposure alters pulmonary microbiota composition and aggravates pneumococcus-induced lung pathogenesis. Front Cell Dev Biol. 2020;8(570434):1-13.
Liu YK, Kuo HC, Lai CH, Chou CC. Single amino acid utilization for bacterial categorization. Sci Rep. 2020;10(1):1-12.
Chen YW, Huang MZ, Chen CL, Kuo CY, Yang CY, Chiang-Ni C, Chen YY, Wu HY, Kuo ML, Chiu CH, Lai CH*. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part Fibre Toxicol. 2020;17(1):1-14.