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A remarkable property of RNA interference (RNAi) in C. elegans is its association with intercellular RNA transport pathways. This allows RNA-based silencing signals to spread from cell-to-cell, including to the germ line, resulting in silencing throughout the animal and its progeny.

To investigate these RNA transport mechanisms we use genetics to identify proteins important for this process and then use an array of methods to determine how the C. elegans proteins and their vertebrate homologs work.

We are also keen to identify the endogenous substrates and functions for these intercellular RNA transport pathways both in the nematode and the mouse.