Generic Protocol

The complete version of the PERTINENT generic protocol is available for download at the bottom of the page.

Objectives

Primary objectives

Primary objectives are to:

• • Estimate the burden of laboratory-confirmed pertussis in hospitalised infants aged less than one year in terms of:

    • • incidence per 100,000 infants

      • severity of confirmed cases, case fatality and mortality rates

  • Estimate pertussis vaccine effectiveness against hospitalisation for laboratory confirmed pertussis in infants aged less than one year

  • Define a model for sentinel surveillance of pertussis in the EU/EEA

Secondary objectives

Potential secondary objectives include to:

• • Estimate the association between pertussis vaccination in mothers and being hospitalised for laboratory confirmed pertussis in infants aged less than one year

  • Estimate the association between breastfeeding, father and siblings’ vaccination, number of siblings, underlying conditions, other risk factors and being hospitalised for laboratory confirmed pertussis in infants aged less than one year

  • Identify the most likely source of infection for infants aged less than one year (mother, father, siblings, etc.)

  • Estimate pertussis vaccine effectiveness against hospitalisation for laboratory confirmed pertussis in infants aged less than one year, by

    • • age group (0-3 months, 4-12 months)

      • number of doses

      • vaccine product

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