Publication

Fallatah A, Anastasakis D, Manzour A, Sharma P, Wang X, Jacob A, Elgerbi A, Alsharif S, Coulombe P, Hafner M, Chung BM. HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs. bioRxiv 2022.01.24.477557; doi: https://doi.org/10.1101/2022.01.24.477557

Sharma P, Tiufekchiev S, Lising V, Chung SW, Suk JS, Chung BM. Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3. Mol Biol Cell. 2021 Aug 18;:mbcE21050255. doi: 10.1091/mbc.E21-05-0255. [Epub ahead of print] PubMed PMID: 34406791.

A Highlights from MBoC Selection

Alsharif S, Sharma P, Bursch K, Milliken R, Lam V, Fallatah A, Phan T, Collins M, Dohlman P, Tiufekchiev S, Nehmetallah G, Raub CB, Chung BM. Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells. Cell Adh Migr. 2021 Dec;15(1):1-17. doi: 10.1080/19336918.2020.1868694. PubMed PMID: 33393839.

Sharma P, Lam VK, Raub CB, Chung BM. Tracking Single Cells Motility on Different Substrates. Methods Protoc. 2020 Aug 4;3(3):E56. doi: 10.3390/mps3030056. PMID: 32759734

Cover Story

Lam VK, Sharma P, Nguyen T, Nehmetallah G, Raub CB, Chung BM. Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate. Cytometry A. 2020 Apr 14. doi: 10.1002/cyto.a.24011. [Epub ahead of print]

Lam V, Nguyen T, Bui V, Chung BM, Chang LC, Nehmetallah G, Raub C. Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging. J Biomed Opt. 2020 Feb;25(2):1-17. doi: 10.1117/1.JBO.25.2.026002. PubMed PMID: 32072775; PubMed Central PMCID: PMC7026523.

Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B, Chung BM. Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. Sci Rep. 2019 Oct 10;9(1):14650. doi: 10.1038/s41598-019-51195-9. PubMed PMID: 31601969.

Sharma P, Alsharif S, Fallatah A, Chung BM. Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin. 2019 May 23;8(5). doi: 10.3390/cells8050497. Review. PubMed PMID: 31126068; PubMed Central PMCID: PMC6562751.

Lam VK, Nguyen T, Phan T, Chung BM, Nehmetallah G, Raub CB. Machine Learning with Optical Phase Signatures for Phenotypic Profiling of Cell Lines. Cytometry A. 2019 Apr 22;. doi: 10.1002/cyto.a.23774. [Epub ahead of print] PubMed PMID: 31008570.

Lam VK, Nguyen TC, Chung BM, Nehmetallah G, Raub CB. Quantitative assessment of cancer cell morphology and motility using telecentric digital holographic microscopy and machine learning. Cytometry A. 2018 Mar;93(3):334-345. doi: 10.1002/cyto.a.23316. Epub 2017 Dec 28. PubMed PMID: 29283496.

Prior to CUA:

Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, Čiháková D, Wan F, Coulombe PA. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355. Epub 2015 Jul 13. PubMed PMID: 26168014; PubMed Central PMCID: PMC4520766.

Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol. 2015 Mar 2;208(5):613-27. doi: 10.1083/jcb.201408026. Epub 2015 Feb 23. PubMed PMID: 25713416; PubMed Central PMCID: PMC4347647.

Chung BM, Tom E, Zutshi N, Bielecki TA, Band V, Band H. Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants. World J Clin Oncol. 2014 Dec 10;5(5):806-23. doi: 10.5306/wjco.v5.i5.806. Review. PubMed PMID: 25493220; PubMed Central PMCID: PMC4259944.

Chung BM, Rotty JD, Coulombe PA. Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol. 2013 Oct;25(5):600-12. doi: 10.1016/j.ceb.2013.06.008. Epub 2013 Jul 22. Review. PubMed PMID: 23886476; PubMed Central PMCID: PMC3780586.

Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA. Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat Struct Mol Biol. 2012 Jun 17;19(7):707-15. doi: 10.1038/nsmb.2330. PubMed PMID: 22705788; PubMed Central PMCID: PMC3864793.

Chung BM, Murray CI, Van Eyk JE, Coulombe PA. Identification of novel interaction between annexin A2 and keratin 17: evidence for reciprocal regulation. J Biol Chem. 2012 Mar 2;287(10):7573-81. doi: 10.1074/jbc.M111.301549. Epub 2012 Jan 10. PubMed PMID: 22235123; PubMed Central PMCID: PMC3293598.

Tu C, Ahmad G, Mohapatra B, Bhattacharyya S, Ortega-Cava CF, Chung BM, Wagner KU, Raja SM, Naramura M, Band V, Band H. ESCRT proteins: Double-edged regulators of cellular signaling. Bioarchitecture. 2011 Jan;1(1):45-48. doi: 10.4161/bioa.1.1.15173. PubMed PMID: 21866262; PubMed Central PMCID: PMC3158637.

Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. J Biol Chem. 2010 Jan 8;285(2):1555-68. doi: 10.1074/jbc.M109.057976. Epub 2009 Oct 13. PubMed PMID: 19826000; PubMed Central PMCID: PMC2801280.

Chung BM, Raja SM, Clubb RJ, Tu C, George M, Band V, Band H. Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src. BMC Cell Biol. 2009 Nov 30;10:84. doi: 10.1186/1471-2121-10-84. PubMed PMID: 19948031; PubMed Central PMCID: PMC2790444.

Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, Band H. The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene. 2009 Apr 23;28(16):1821-32. doi: 10.1038/onc.2009.31. Epub 2009 Mar 23. PubMed PMID: 19305428; PubMed Central PMCID: PMC2752420.

Full list of publications:

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