Tandem Catalysis

In the Carney laboratory we are interested in developing new methods in the synthesis of biologically-active compounds and common molecular architectures. Taking our inspiration from certain enzymes, nature's catalysts, we look to design reactions that form numerous bonds in a single reaction flask, which is often termed a tandem or domino process. In place of enzymes, transition and post-transition metal catalysts are capable of a promoting or catalyzing a diverse array of reactions and make excellent candidates for building molecular complexity through multiple transformations in a single flask.

Our initial projects are taking a look at constructing oxygen and nitrogen heterocycles through the use of catalyzed reactions designed as shown in Scheme 1.

ASSOCIATED PRESENTATIONS:

RAPID CONSTRUCTION OF DIHYDROPYRANS VIA A TANDEM SAKURAI/SILYL-PRINS REACTION SEQUENCE. David N. McCartney, Clinton J. Bronder, & Jeffrey M. Carney, Department of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA 23606. 244^th National Meeting of the American Chemical Society, Philadelphia, PA; American Chemical Society, Philadelphia, PA, August 22, 2012. (Published Abstract) (Poster)