Research interests

My current research interests are within the biophysics of molecular, macromolecular and subcellular systems. I have been working on such topics as: 

• adhesion of cellular and biomimetic membranes, 

• formation of domains and patterns in multicomponent membranes, 

• adhesion-induced condensation of membrane receptors and lipid rafts, 

• stability of clusters of adhesion protein complexes in the immunological synapse, 

• interactions of solute molecules with lipid membranes, 

• curvature generation in model membranes, 

• mechanics of the membrane-protein sorting ESCRT system, 

• molecular mechanisms of activity regulation of protein and lipid kinases, 

• ensemble refinement methods based on low resolution and/or sparse data, 

• conformational transitions of multi-domain proteins with intrinsically disordered segments, 

• thermal and mechanical stability of multi-domain proteins and multi-protein complexes, 

• properties of peptide linker modules in cellulosome multi-enzyme complexes.