Publications
Di Tommaso E, Giunta S†. 'Dynamic interplay between human alpha-satellite DNA structure and centromere functions' 2023 Nov. doi.org/10.1016/j.semcdb.2023.10.002
Marcon F, Giunta S, Bignami M. 'Emerging roles of DNA repair factors in the stability of centromeres.' Semin Cell Dev Biol. 2023 Oct 16:S1084-9521(23)00170-2. doi: 10.1016/j.semcdb.2023.10.001.
Parisis N, Dans PD, Jbara M, Singh B, Schausi-Tiffoche D, Molina-Serrano D, Brun-Heath I, Hendrychová D, Maity SK, Buitrago D, Lema R, Nait Achour T, Giunta S, Girardot M, Talarek N, Rofidal V, Danezi K, Coudreuse D, Prioleau MN, Feil R, Orozco M, Brik A, Wu PJ, Krasinska L, Fisher D. 'Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair.' Nat Commun. 2023 Aug 22;14(1):5104. doi: 10.1038/s41467-023-40843-4.
Bosco N, Goldberg A, Zhao X, Mays JC, Cheng P, Johnson AF, Bianchi JJ, Toscani C, Di Tommaso E, Katsnelson L, Annuar D, Mei S, Faitelson RE, Pesselev IY, Mohamed KS, Mermerian A, Camacho-Hernandez EM, Gionco CA, Manikas J, Tseng YS, Sun Z, Fani S, Keegan S, Lippman SM, Fenyö D, Giunta S, Santaguida S, Davoli T. 2023 'KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres'. Cell 186(9):1985-2001.e19.
doi: 10.1016/j.cell.2023.03.029
Di Tommaso E, de Turris V, Choppakatla P, Funabiki H, Giunta S†. 2023 'Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by superresolution microscopy'. Mol Biol Cell 34(6):ar61.
doi: 10.1091/mbc.E22-08-0332
Said M, Barra V, Balzano E, Talhaoui I, Pelliccia F, Giunta S, Naim V. 2022 'FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells'. Commun Biol. 5(1):1395.
doi: 10.1038/s42003-022-04360-2.
Balzano E, Di Tommaso E, Antoccia A, Pelliccia F†, Giunta S†. 2022 ‘Characterization of Chromosomal Instability in Glioblastoma’. Front Genet, 28(12):810793.
Giunta S,. 2021 ‘Decoding human cancer with whole genome sequencing: a review of PCAWG Project studies published in February 2020’. Cancer Metastasis Rev, 40(3):909-924.
Giunta S†,*, Herve S,* White R, Wilhelm T, Dumont M, Wong CK, Rancati G, Smogorzewska A, Funabiki H†, Fachinetti D†. 2021 ‘CENP-A preserves genome integrity during alpha-satellite DNA replication by modulating R-loops at human centromeres’. PNAS, 118(10) e2015634118.
BioRvix doi.org/10.1101/2020.09.01.277103
Highlighted by The Company of Biologists Prelights
Balzano E, Pelliccia F, Giunta S†. 2020 ‘Genome (in)stability at tandem repeats’. Seminars in Cell & Developmental Biology, S1084-6.
Burla R, La Torre M, Maccaroni K, Verni F, Giunta S, Saggio I. 2020 ‘Nuclear envelope and chromatin organization in physiology and pathology’. Nucleus, 11(1):205-218.
Balzano E & Giunta S†. 2020 ‘Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function’. Genes, 11(8):912.
Leo L, Marchetti M, Giunta S, Fanti L. 2020 ‘Epigenetics as an Evolutionary Tool for Centromere Flexibility’. Genes, 11(7):809.
Maccaroni K, Balzano E, Mirimao F, Giunta S†, Pelliccia F†. 2020 ‘Impaired replication timing promotes tissue-specific expression of common fragile sites’. Genes, 11, 326.
Black EM & Giunta S†.2018 ‘Repetitive Fragile Sites: Centromere Satellite DNA as a Source of Genome Instability’. Genes, 9, 615.
Giunta S,. 2018 ‘Centromere Chromosome Orientation Fluorescent In Situ Hybridization (Cen-CO-FISH) detects Sister Chromatids Exchange at Centromeres in Human Cells’. Bio-protocol, 7(8), e2792.
Jenness C, Giunta S, Muller MM, Kimura H, Muir TW, Funabiki H. 2018 ‘HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome’ PNAS, 45, 201717509.
Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, Ross CA, Dang L, Liu Z, Giunta S, et al. 2017 ‘ZSCAN10 corrects the genomic instability of iPSC from aged donors’, Nature Cell Biology 19(9), 1037-48.
Giunta S† & Funabiki H†. 2017 ‘Integrity of the human centromere DNA repeats is protected by CENP-A CENP-C and CENP-T’. Proceedings of the National Academy of Science (PNAS) 114(8), 1928-33
Valdiglesias V*, Giunta S*, Neri M, Bonassi S. 2013 ‘gH2AX as a marker of DNA double strand breaks and genomic instability in human population studies’. Mutation Research 753(1), 24-40
Giunta S & Jackson SP. 2011 ‘Give me a break, but not in mitosis: The mitotic DNA damage response marks DNA double strand breaks with early signaling events’. Cell Cycle 10, 1215-21.
Giunta S*, Belotserkovskaya R*, Jackson SP. 2010 ‘DNA damage signalling in response to double strand breaks during the cell cycle phase of mitosis’. Journal of Cell Biology 190, 197-207.
Highlighted by Journal of Cell Biology and Nature Reviews Cancer.
Giunta S. 2009 ‘A gust of WNT: Analysis of the canonical WNT pathway’. ACTA Biomed 81(3), 187-99
LEGEND: † Corresponding author. * Equal contribution