Gallery

Axonal ribosomes

Immuno-gold EM image of ribosomes (gold particles) in myelinated (pink) axons (blue) in the mouse optic nerve (Cell 2016)

Mature mammalian central nervous system axons contain ribosomes (H Jung & J Jung).

Developmental brake on vessel growth

AcLDL-DiI labeling of the vasculature in wildtype (magenta), Tie2 loss-of-function (green), and Tie2 gain-of-function (red) conditions (ATVB 2016; J Vis Exp 2017)

Balanced Tie2 signaling is required for controlled development of the vasculature (J Ohk).

Chemokine signaling caught in the act

Visualization of chemokine CCL2 (red) /chemokine receptor CCR2 (green) signaling in the bone marrow in transgenic reporter mice (Plos one 2015)

Pre-made CCL2 chemokines are rapidly released from stromal cells in the bone marrow upon inflammation and activate CCR2 receptors expressed by adjacent monocytes (green). Endocytosis of ligand-receptor complexes (yellow) indicates that CCL2/CCR2 signaling has been activated in the cell (H Jung).

Crispr/Cas9 in frog

Gene knockout in F0 generation in Xenopus tropicalis by Crispr/Cas9

Knockout of the tyrosinase gene (tyr), which is required for melanin synthesis, results in the loss of pigments in the retinal 'pigment' epithelium (arrow) (J Jung & J Hong).

Vimentin filament regulates neural tube closure

(FEBS lett 2016) (J Jang)

Visualizing axon death and survival in vivo

(Mol Cells 2022) (H Kim)

Naive (cyan) and axotomized (magenta) retinal ganglion cell axons in Xenopus tropicalis

Presynaptic RNA

EM image of 5-ethynyl uridine (EU)-labeled RNAs (DAB, dark) in retinal ganglion cell axons terminating in the superior colliculus (green arrow) (Neuron 2023)