Estrogen and the Thyroid
Estrogen blocks thyroid hormone production
Thyroid stimulating hormone production is blunted by somatostatin (SRIH), rising levels of glucocorticoids (ex. cortisol) and sex hormones (estrogen and testosterone), and excessively high blood iodide.
http://en.wikipedia.org/wiki/Thyroid
Estrogen reduces the effectiveness of thyroid hormones
Excess estrogen can reduce the effect of thyroid hormone and lock it out from receptor sites on tissue cells.
http://www.baumancollege.com/Articles/hashimotos-article.html
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Estrogen blocks thyroid hormones by increasing the production of TBG
If a protein called thyroid binding globulin (TBG) level is high, which can occur when estrogen levels are high, the TBG will bind more thyroid hormone, decreasing the free hormone available in the blood, which leads to stimulation of TSH, and the production of more thyroid hormone. T4 circulates in the blood in two forms: 1) T4 bound to proteins that prevent the T4 from entering the various tissues that need thyroid hormone and 2) free T4, which does enter the various target tissues to exert its effects.
http://www.reference.com/browse/Thyroxine-binding_globulin
Estrogen linked to autoimmune disease
Both estrogen and prolactin induce lupus in mice.
http://linkinghub.elsevier.com/retrieve/pii/S1571507807002036
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Other pages located under Estrogen:
Estrogen and Fibrocystic Breast