Publications: 2016-2020

245. Hongjian He, Weiyi Tan, Jiaqi Guo, Meihui Yi, Adrianna N. Shy and Bing Xu* “Enzymatic Noncovalent Synthesis” Chemical Reviews, 2020, 18, 9994-10078.

244. Hongjian He, Xinyi Lin, Difei Wu, Jiaqing Wang, Jiaqi Guo, Douglas R. Green, Hongwei Zhang, and Bing Xu* “Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells” Cell Reports Physical Science, 2020, 1, 100270.

243. Hongjian He, Shuang Liu, Difei Wu, and Bing Xu* "Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells" Angewandte Chemie International Edition 2020, 59, 16445-16450.

242. Dongsik Yang, Hongjian He and Bing Xu* “Enzyme-Instructed Morphological Transition of the Supramolecular Assemblies of Branched Peptides” Beilstein Journal of Organic Chemistry, 2020, 16, 2700-2718.

241. Jiaqi Guo, Hongjian He, Beomjin Kim, Jiaqing Wang, Meihui Yi, Cheng Lin, and Bing Xu* “The Ratio of Hydrogelator and Precursor Controls Enzymatic Hydrogelation of a Branched Peptide” Soft Matter, 2020, 16, 10101-10105.

240.  Adrianna N. Shy, Jie Li, Junfeng Shi, Ning Zhou, and Bing Xu* “Enzyme-Instructed Self-assembly of the Stereoisomers of Pentapeptides to Form Biocompatible Supramolecular Hydrogels” Journal of Drug Targeting, 2020, 28, 760-765.

239. Jiaqing Wang, Weiyi Tan, Guanying Li, Difei Wu, Hongjian He, Jiashu Xu, Meihui Yi, Ye Zhang, S. Ali Aghvami, Seth Fraden, Bing Xu* “Enzymatic Insertion of Lipids Increases Membrane Tension for Inhibiting Cancer Cells” Chemitry: European Journal 2020, 26, 15116-15120.

238. Beom Jin Kim, Yu Fang, Hongjian He, and Bing Xu* "Trypsin-Instructed Self-Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells " Advanced Healthcare Materials. 2020, 2000416.

237. Jiaqi Guo, Changhao Tian and Bing Xu* “Biomaterials Based on Noncovalent Interactions of Small MoleculesEXCLI Journal, 2020, 19, 1124-1140.

236. Zhaoqianqi Feng, Huaimin Wang, Fengbin Wang, Younghoon Oh, Cristina Berciu, Qiang Cui,* Edward H. Egelman* and Bing Xu* "Artificial Intracellular Filaments" Cell Reports Physical Science. 2020, 1, 10085.

235. Hongjian He, Jiaqi Guo, Xingyi Lin and Bing Xu* "Enzyme-Instructed Assemblies Enable Mitochondria Localization of H2B in Cancer Cells" Angewandte Chemie International Edition 2020, 59, 9330-9334.

234. Hongjian He, Xingyi Lin, Jiaqi Guo, Jiaqing Wang, and Bing Xu* "Perimitochondrial Enzymatic Self-Assembly for Selective Targeting the Mitochondria of Cancer Cells" ACS Nano. 2020, 14, 6947-6955.

233. Shuang Liu and Bing Xu* "Enzyme-Instructed Self-Assembly for Subcellular Targeting" ACS Omega. 2020, 5, 15771-15776.

232. Zhaoqianqi Feng, Huaimin Wang, Meihui Yi, Chieh-Yun Lo, Ashanti Sallee, Jer-Tsong Hsieh and Bing Xu* “Instructed-Assembly of Small Peptides Inhibits Drug-Resistant Prostate Cancer Cells” Peptide Science 2020, 1, e24123.

231. Beom Jin Kim, Bing Xu* “Enzyme-Instructed Self-Assembly for Cancer Therapy and Imaging” Bioconjugate Chemistry 2020, 31, 492-500.

230. Beom Jin Kim, Dongsik Yang, and Bing Xu* “Emerging Applications of Supramolecular Peptide Assemblies” Trends in Chemistry 2020, 2, 71-83.

229. Huaimin Wang, Zhaoqianqi Feng, Weiyi Tan, Bing Xu* “Assemblies of D-peptides for Targeting Cell Nucleolus” Bioconjugate Chemistry 2019, 30, 2528-2532.

228. Jiaqing Wang, Adrianna Shy, Difei Wu, Deani Cooper, Jiashu Xu, Hongjian He, Wenjun Zhan, Shenghuan Sun, Susan Lovett, Bing Xu* “The Structure-Activity Relationship of Peptide Conjugated Chloramphenicol for Inhibiting E. coli” J. Med. Chem 2019, 62, 10245-10257.

227. Adrianna N. Shy, Beom Jin Kim, and Bing Xu* “Enzymatic Noncovalent Synthesis of Supramolecular Soft Matters for Biomedical Applications” Matter 2019, 1, 1127-1147.

226. Huaimin Wang, Zhaoqianqi Feng, and Bing Xu* “Assemblies of Peptides in Complex Environment and Their Applications” Angewandte Chemie International Edition 2019, 58, 10423-10432.

225. Huaimin Wang, Zhaoqianqi Feng, and Bing Xu* “Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids” Journal of the American Chemical Society 2019, 141, 7271-7274.


224. Jiaqing Wang, Deani L. Cooper, Wenjun Zhan, Difei Wu, Hongjian He, Shenghuan Sun, Susan Lovett,* Bing Xu* “Diglycine Enables Rapid Intrabacterial Hydrolysis for Activating Anbiotics against Gram-negative Bacteria” Angewandte Chemie International Edition 2019, 58, 10631- 10634.

223. Huaimin Wang, Zhaoqianqi Feng, and Bing Xu* “Instructed-Assembly as Context-Dependent Signals for Death and Morphogenesis of Cells” Angewandte Chemie International Edition 2019, 58, 5567-5571.

222. Zhaoqianqi Feng, Xiuguo Han, Huaimin Wang, Tingting Tang,* and Bing Xu* “Enzyme- Instructed Peptide Assemblies Selectively Inhibit Bone TumorsChem 2019, 5, 2442-2449.

221. Huaimin Wang,* Zhaoqianqi Feng, and Bing Xu* “Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery” Theranostics 2019, 9, 3213-3222.

220. Huaimin Wang, Zhaoqianqi Feng, and Bing Xu* “Dynamic Continuum of Molecular Assemblies for Controlling Cell Fates” ChemBioChem 2019, 20, 2442-2446.

219. Huaimin Wang, Zhaoqianqi Feng, Cuihong Yang, Jinjian Liu, Jamie E. Medina, S. Ali Aghvami, Daniela M. Dinulescu, Jianfeng Liu, Seth Fraden, and Bing Xu* “Unraveling the Cellular Mechanism of Assembling Cholesterols for Selective Cancer Cell Death". Molecular Cancer Research 2019, 17, 907-917

218. Jiaqing Wang, Jie Zhou, Hongjian He, Difei Wu, Xuewen Du, Bing Xu* “Cell-compatible Nanoprobes for Imaging Intracellular Phosphatase Activities” ChemBioChem, 2019, 20, 526- 531.

217. Jie Zhou; Xuewen Du; Xiaoyi Chen; Bing Xu* “Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis". Biochemistry 2018, 57, 4867- 4879.

216. Hongjian He; Bing Xu* “Instructed-Assembly (Ia): A Molecular Process for Controlling Cell Fate". Bulletin of the Chemical Society of Japan 2018, 91, 900-906.

215. Jie Zhou; Xuewen Du; Cristina Berciu; Steven J. Del Signore; Xiaoyi  Chen; Natsuko Yamagata; Avital A. Rodal; Daniela Nicastro; Bing Xu* “Cellular Uptake of a Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative Via Dynamin-Based Endocytosis and Macropinocytosis". Molecular Therapy 2018, 26, 648-658.

214. Qingxin Yao; Qiang Bao; Xinming Li; Hui Wang; Zhenyu Yang; Xinghua Shi; Yuan Gao*; Bing Xu “Determination of the Packing Model of a Supramolecular Nanofiber Via Mass-Per-Length Measurement and De Novo Simulation". Nanoscale 2018, 10, 3990-3996.

213. Jiaqing Wang; Taotao Xiong; Jie Zhou; Hongjian He; Dongdong Wu; Xuewen Du; Xingyi Li; Bing Xu* “Enzymatic Formation of Curcumin in Vitro and in Vivo". Nano Research 2018, 11, 3453-3461.

212. Zhaoqianqi Feng, Huaimin Wang and Bing Xu* “Instructed-Assembly of Peptides for Intracellular Enzyme Sequestration.” Journal of the American Chemical Society 2018, 140, 16433-16437.

211. Huaimin Wang; Zhaoqianqi Feng; Yanan Qin; Jiaqing Wang; Bing Xu* “Nucleopeptide Assemblies Selectively Sequester Atp in Cancer Cells to Increase the Efficacy of Doxorubicin". Angewandte Chemie International Edition 2018, 57, 4931-4935.

210. Zhaoqianqi Feng; Huaimin Wang; Shiyu Wang; Qiang Zhang; Xixiang Zhang; Avital A. Rodal; Bing Xu* “Enzymatic Assemblies Disrupt the Membrane and Target Endoplasmic Reticulum for Selective Cancer Cell Death". Journal of the American Chemical Society 2018, 140, 9566-9573.

209. Jie Li; Ziqing Zhan; Xuewen Du; Jiaqing Wang; Brandon Hong; Bing Xu* “Selection of Secondary Structures of Heterotypic Supramolecular Peptide Assemblies by an Enzymatic Reaction". Angewandte Chemie International Edition 2018, 57, 11716-11721.

208. Huaimin Wang; Zhaoqianqi Feng; Steven J. Del Signore; Avital A. Rodal; Bing Xu* “Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas". Journal of the American Chemical Society 2018, 140, 3505-3509.

207. Jie Zhou; Xuwen Du; Xiaoyi Chen; Jiaqing Wang; Ning Zhou; Dongdong Wu; Bing Xu* “Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with Nf-Kappab Targeting for Selective Necroptosis of Cancer Cells". Journal of the American Chemical Society 2018, 140, 2301-2308.

206. Hongjian He; Jiaqing Wang; Huaimin Wang; Ning Zhou; Dongsik Yang; Douglas R. Green; Bing Xu* “Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria". Journal of the American Chemical Society 2018, 140, 1215-1218.

205. Jie Li; Xuewen Du; Devon J. Powell; Rong Zhou; Junfeng Shi; Hongjian He; Zhaoqianqi Feng; Bing Xu* “Down-Regulating Proteolysis to Enhance Anticancer Activity of Peptide Nanofibers". Chemistry-an Asian journal 2018, 13, 3464-3468

204. Jie Li; Domenico Bullara; Xuewen Du; Hongjian He; Stavroula Sofou; Ioannis G. Kevrekidis; Irving R. Epstein*; Bing Xu* “Kinetic Analysis of Nano-Structures Formed by Enzyme- Instructed Intracellular Assemblies against Cancer Cells". ACS Nano 2018, 12, 3804-3815.

203. Hongjian He; Huaimin Wang; Ning Zhou; Dongsik Yang; Bing Xu* “Branched Peptides for Enzymatic Supramolecular Hydrogelation". Chemical Communications 2018, 54, 86-89.

202. Ning Zhou; Zeyuan Cao; Bing Xu* “Functional Hyper-Crosslinkers". Chemistry-a European Journal 2017, 23, 15844-15851.

201. Ning Zhou; Xiaoyan Cao; Xuewen Du; Huaimin Wang; Ming Wang; Shuang Liu; Nguyen Khang; Klaus Schmidt-Rohr; Qiaobing Xu; Gaolin Liang; Bing Xu* “Hyper-Crosslinkers Lead to Temperature- and Ph-Responsive Polymeric Nanogels with Unusual Volume Change". Angewandte Chemie International Edition 2017, 56, 2623-2627.

200. Cuihong Yang; Chunhua Ren; Jie Zhou; Jinjian Liu; Yumin Zhang; Fan Huang; Dan Ding; Bing Xu*; Jianfeng Liu* "Dual Fluorescent- and Isotopic-Labelled Self-Assembling Vancomycin for in Vivo Imaging of Bacterial Infections". Angewandte Chemie International Edition 2017, 56, 2356- 2360.

199. Huaimin Wang; Junfeng Shi; Zhaoqianqi Feng; Rong Zhou; Shiyu Wang; Avital A. Rodal; Bing Xu* “An in Situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3d Cell Spheroids". Angewandte Chemie International Edition 2017, 56, 16297- 16301.

198. Huaimin Wang; Zhaoqianqi Feng; Alvin Lu; Yujie Jiang; Hao Wu; Bing Xu* “Instant Hydrogelation Inspired by Inflammasomes". Angewandte Chemie International Edition 2017, 56, 7579-7583.

197. Jie Li; Xuewen Du; Saqib Hashim; Adrianna Shy; Bing Xu* “Aromatic-Aromatic Interactions Enable Alpha-Helix to Beta-Sheet Transition of Peptides to Form Supramolecular Hydrogels".Journal of the American Chemical Society 2017, 139, 71-74.

196. Zhaoqianqi Feng; Huaimin Wang; Xiaoyi Chen; Bing Xu* “Self-Assembling Ability Determines the Activity of Enzyme-Instructed Self-Assembly for Inhibiting Cancer Cells". Journal of the American Chemical Society 2017, 139, 15377-15384.

195. Zhaoqianqi Feng; Huaimin Wang; Rong Zhou; Jie Li; Bing Xu* “Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells". Journal of the American Chemical Society 2017, 139, 3950-3953.

194. Jie Zhou; Jie Li; Xuewen Du; Bing Xu* “Supramolecular Biofunctional Materials". Biomaterials 2017, 129, 1-27.

193. Jie Zhou; Xuewen Du; Jiaqing Wang; Natsuko Yamagata; Bing Xu* “Enzyme-Instructed Self- Assembly of Peptides Containing Phosphoserine to Form Supramolecular Hydrogels as Potential Soft Biomaterials". Frontiers of Chemical Science and Engineering 2017, 11, 509-515.

192. Xue Zhang; Peng Liu; Christie Zhang; Direkrit Chiewchengchol; Fan Zhao; Hongbo Yu; Jingyu Li; Hiroto Kambara; Kate Y. Luo; Arvind Venkataraman; Ziling Zhou; Weidong Zhou; Haiyan Zhu; Li Zhao; Jiro Sakai; Yuanyuan Chen; Ye-Shih Ho; Besnik Bajrami; Bing Xu; Leslie E. Silberstein; Tao Cheng; Yuanfu Xu; Yuehai Ke; Hongbo R. Luo "Positive Regulation of Interleukin-1 Beta Bioactivity by Physiological Ros-Mediated Cysteine S-Glutathionylation". Cell Reports 2017, 20, 224-235.

191. Natsuko Yamagata; Xiaoyi Chen; Jie Zhou; Jie Li; Xuewen Du; Bing Xu* “Enzymatic Self- Assembly of an Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM)". Organic & Biomolecular Chemistry 2017, 15, 5689-5692.

190. Huaimin Wang; Zhaoqianqi Feng; Bing Xu* “Bioinspired Assembly of Small Molecules in Cell Milieu". Chemical Society Reviews 2017, 46, 2421-2436.

189. Jie Li; Junfeng Shi; Jamie E. Medina; Jie Zhou; Xuewen Du; Huaimin Wang; Cuihong Yang; Jianfeng Liu; Zhimou Yang; Daniela M. Dinulescu; Bing Xu* “Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives". Advanced Healthcare Materials 2017, 6. 1601400.

188. Zhaoqianqi Feng; Tengfei Zhang; Huaimin Wang; Bing Xu* “Supramolecular Catalysis and Dynamic Assemblies for Medicine". Chemical Society Reviews 2017, 46, 6470-6479.

187. Xuewen Du; Jie Zhou; Jiaqing Wang; Rong Zhou; Bing Xu* “Chirality Controls Reaction-Diffusion of Nanoparticles for Inhibiting Cancer Cells". Chemnanomat 2017, 3, 17-21.

186. Xuewen Du; Jie Zhou; Huainin Wang; Junfeng Shi; Yi Kuang; Wu Zeng; Zhimou Yang; Bing Xu* “In Situ Generated D-Peptidic Nanofibrils as Multifaceted Apoptotic Inducers to Target Cancer Cells". Cell Death & Disease 2017, 8, e2614-e2614.

185. Xuewen Du; Jie Zhou; Xinming Li; Bing Xu* “Self-Assembly of Nucleopeptides to Interact with DNAs". Interface Focus 2017, 7, 20160116.

184. Rong Zhou; Yi Kuang; Jie Zhou; Xuewen Du; Jiayang Li; Junfeng Shi; Richard Haburcak; Bing Xu* “Nanonets Collect Cancer Secretome from Pericellular Space". PLoS One 2016, 11, e0154126.

183. Jie Zhou; Michael O'keeffe; Gongxian Liao; Fan Zhao; Cox Terhorst; Bing Xu* “Design and Synthesis of Nanofibers of Self-Assembled De Novo Glycoconjugates Towards Mucosal Lining Restoration and Anti-Inflammatory Drug Delivery". Tetrahedron 2016, 72, 6078-6083.

182. Jie Zhou; Xuewen Du; Bing Xu* “Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells". Angewandte Chemie International Edition 2016, 55, 5770-5775.

181. Jie Zhou; Xuewen Du; Cristina Berciu; Hongjian He; Junfeng Shi; Daniela Nicastro; Bing Xu* “Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells". Chem 2016, 1, 246-263.

180. Huaimin Wang; Zhaoqianqi Feng; Dongdong Wu; Keith J. Fritzsching; Mike Rigney; Jie Zhou; Yujie Jiang; Klaus Schmidt-Rohr; Bing Xu* “Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells". Journal of the American Chemical Society 2016, 138, 10758-10761.

179. Huaimin Wang; Zhaoqianqi Feng; Youzhi Wang; Rong Zhou; Zhimou Yang; Bing Xu* “Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance". Journal of the American Chemical Society 2016, 138, 16046-16055.

178. Richard Haburcak; Junfeng Shi; Xuewen Du; Dan Yuan; Bing Xu* “Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules". Journal of the American Chemical Society 2016, 138, 15397-15404.

177. Dan Yuan; Bing Xu* “Heterotypic Supramolecular Hydrogels". Journal of Materials Chemistry B 2016, 4, 5638-5649.

176. A. P. Mccloskey; S. M. Gilmore; J. Zhou; E. R. Draper; S. Porter; B. F. Gilmore; Bing Xu; G. Laverty "Self-Assembling Ultrashort Nsaid-Peptide Nanosponges: Multifunctional Antimicrobial and Anti-Inflammatory Materials". RSC Advances 2016, 6, 114738-114749.

175. Zhaoqianqi Feng; Huaimin Wang; Xuewen Du; Junfeng Shi; Jie Li; Bing Xu* “Minimal C-Terminal Modification Boosts Peptide Self-Assembling Ability for Necroptosis of Cancer Cells". Chemical Communications 2016, 52, 6332-6335