09:00 - 09:50
Registration & coffee
09:50 - 10:00
Welcome
Session 1
Chair: André Voelzmann (University of Hull)
10:00 - 10:15
Roisin Cassidy (University of Manchester)
Using proximity labelling and mass spectrometry to identify novel interactors of the ESCRT-1 protein UBAP1
10:15 - 10:30
Mahmoud Eldahshoury (Leeds Beckett University)
The use of plant extracellular vesicles as a drug delivery system
10:30 - 10:45
Tong Chen (University of Manchester)
Identification and characterisation of novel chemical modulators of secretion
10:45 - 11:00
Flash talks 1
Poster numbers 1, 2, 5, 28, 34 (randomly chosen from abstracts)
11:00 - 12:00
Coffee & Poster session 1
Session 2
Chair: Kerrie Marie (University of Manchester)
12:00 - 12:15
Andrew Plygawko (University of Sheffield)
Asymmetric cell divisions produce cell fate diversity in the Drosophila embryonic midgut
12:15 - 12:30
Lucy Smith (Durham University)
Senescent dermal fibroblasts influence epidermal keratinocyte behaviour and epidermal structure in bioengineered models of ageing human skin
12:30 - 12:45
Dhananjay Jade (University of Leeds)
How does the scavenger receptor LOX-1 recognise oxidation of LDL?
12:45 - 14:00
Lunch
Session 3
Chair: Elena Rainero (University of Sheffield)
14:00 - 14:15
Victoria Liu (Durham University)
Histone and carbon dioxide sensing
14:15 - 14:30
Gabrielle Ecclestone (University of Liverpool)
Identification of IGF2BP3 as a novel repressor of HIF1α signalling
14:30 - 14:45
Sarena Banu Nagoor Pitchai (University of Hull)
Effects of simulated heatwaves on the social amoeba Dictyostelium discoideum at single-cell and multicellular stages
14:45 - 15:00
Flash talks 2
Poster numbers: 35, 38, 39, 46 (randomly chosen from abstracts)
15:00 - 16:00
Coffee & Poster session 2
Session 4
Chair: Viki Allan (University of Manchester)
16:00 - 16:15
Sonia Fanelli (University of Liverpool)
DUB regulators of YAP/TAZ activity in mesothelioma and head and neck cancer
16:15 - 16:30
Alima Ismail (University of Leeds)
Characterising an intrinsic and environment-dependent glioblastoma invasion signature into neural and endodermal environments
16:30 - 16:45
Victoria Hart (University of Sheffield)
The impact of cell shape and mechanics on KRAS inhibition in pancreatic cancer
16:45 - 17:00
Concluding remarks, future meeting discussion, and prize giving
17:30 -
Optional social at BrewYork
Poster List
1) Mashael Saud Aladwani: Identification and functional characterization of MCPH1/BRIT1 synthetic lethal genes to treat breast cancer
*flash talk in session 1*
2) Imogen Guy: Evaluation of novel microwave probes for treatment of peripheral arterial disease (MICRO-PAD)
*flash talk in session 1*
3) Blythe Wright: Dysregulation of membrane trafficking regulator Vps45 is implicated in severe congenital neutropenia.
4) Laura Offler: Vascular Endothelial Cell Damage, Its Role in Vascular Complications of Diabetes and the Potential of Dietary Interventions
5) Olivia Dean: Evaluating the role of WSB-1 in breast cancer bone metastasis
*flash talk in session 1*
6) Emily Moss: The role of breast cancer CAF derived EVs on establishing a pre-metastatic niche promoting cancer metastasis
7) Natalia Georgiadou: Understanding heart failure phenotypes: effects on cardiomyocyte organisation
8) Malika Zahedi: Developing novel tools to uncover smooth and non-muscle myosin organisation in the smooth muscle of blood vessels.
9) Esme Hutton: Resurrecting the ancient glycome to explore the anti-Neu5Gc immune response
10) Nicole Barrett: Applications of Bioengineered Human Skin Equivalents to Study Grooming Practices In Vitro
11) Sabrina Amran: A Transcript and Protein Analysis: shedding some light on the multifaceted properties of CCR5 in Prostate Cancer
12) Aneesa Ahmed: Therapeutic Resolution of Pulmonary Arterial Hypertension by Natural Products
13) Lizzie Courthold: GLUT4 vesicles are a subtype of Intracellular Nanovesicle
14) Alice Fearn: Wound Metallomics: Identifying Novel Strategies to Boost Diabetic Wound Healing
15) Attila Munkacsi: Targeting the myosin light chain phosphatase with peptide disruptors: a novel antiplatelet therapeutic approach
16) Charlotte Cook: AMPK inhibition of endothelial V617F-JAK2: a new approach to manage haemostatic dysfunction in myeloproliferative neoplasms
17) Ahmed Salem: Regulation of alternative splicing by cell density
18) Isabella Davis: How does the stiffness of the extracellular environment affect the cell cycle in pancreatic cancer cells and their response to cell cycle targeting drugs?
19) Madeleine Coy: Impact of COL1A1 Knockdown on Type I Collagen Fibril Formation and Circadian Rhythmicity in IPF-Patient Derived Lung Fibroblasts
20) Noha Abdelrazik: Does the Endosomal Sorting Complex Required for Transport (ESCRT) have a role in acquired drug resistance in colorectal cancer?
21) Hayley Pearson: What can viruses tell us about the role of potassium ions and channels during endosomal trafficking?
22) Courtney Riley: The effects of carbon monoxide on cardiac function
23) George Hatton: Is Interferon Signalling the Mechanism for Bystander Carcinogenesis during BK Polyomavirus Infection of Human Urothelium?
24) Lucie Bilton: Investigating the carcinogenic and epigenetic modulating effects of per- and poly-fluoroalkyl substances (PFAS) on breast cancer development
25) Angel Garcia: Investigating arginine methylation as a novel post-translational modification of the critical platelet integrin, αIIbβ3
26) Luke Owen: Developing a real-time imaging pipeline to screen for inflammatory regulators in melanoma cell states acquisition
27) Jinlong Qiu: Arginine methylation plays a critical role in bovine embryo development
28) Mohamed Shalaby: Glutamatergic pharmacology and receptor modifications by knocking down of ESCRT proteins
*flash talk in session 1*
29) Lauren Colborn: Elucidating the Role of Immune Cell Senescence in Chronic Wound Repair
30) Muneera Alshammari: Elucidating Ran-mediated Pathway in Triple Negative Breast Cancer (TNBC): Potential Therapeutic Effect of Mebendazole and siRan in MDA-MB231 cell lines.
31) Bian Yanes: Extracellular matrix receptors of the integrin family control cancer cell growth under nutrient starvation
32) Danielle Marsh: The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma
33) Anna Gavrilova: The role of Kinesin - 1 in neuronal dense core vesicle transport , locomotion and lifespan regulation in C. elegans
34) Jenny Baker: Cx32 Gap Junctions & Urothelial Homeostasis
*flash talk in session 1*
35) Leah Cooksey: A Novel Estrogenic Therapy Prevents Cellular Ageing and Accelerates Tissue Repair Following Injury.
*flash talk in session 2*
36) Wanzhu Jia Platelet: PD-L1 Deficiency Exacerbates Atherosclerosis: Insights from a Novel Mouse Model
37) Jordan-Lee Greaves: The effect of hyperglycaemia on platelet responses in vitro.
38) John Knox: Endocytosed collagen-I trafficking may involve retrograde Golgi to ER transport in human lung fibroblasts
*flash talk in session 2*
39) Rachel Lawson: Investigating the mechanical and adhesive properties of cell division within a tissue, and the role of oncogenic Ras in regulating these
*flash talk in session 2*
40) Justas Stanislovas: Novel ESCRT-III subunit-like behaviour, morphology, and evolutionary conservation of VIPP1 in Saccharomyces cerevisiae
41) Ife Oyelade: Characterisation of the role of the extracellular matrix in promoting pancreatic cancer cell growth under nutrient starvation
42) Thomas Francis: Investigating the Epigenetic Regulatory Protein CBX2 as a Novel Therapeutic Target for Advanced Cancer
43) Iona Norwood: How does the rate of stretch impact cells in epithelia?
44) John Robert Davis: Monolayer stress generation and transmission is dictated by focal adhesion distribution
45) Kerrie Marie: Embryonic gene module re-expression in melanoma yields insights into a Hdac2-driven mechanism of plastic adaptation
46) Deanna Howley: Statins Inhibit Platelet-induced Colorectal Cancer Metastatic Responses
*flash talk in session 2*