2024
Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity. Kim U, Hwang S, Cho S, Kim HY, Ban H, Park J, Mun J, Kim N, Suh JH, Choi J, Shin Y, Kim SB, Yoon I, Kwon HS, Kim S. Front. Immunol. 2024 Nov;15:1454504.
AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells. Kim Y, Kim SB, Lee H, Kim D, Bak SS, Yoon I, Cho S, Jeong SJ, Jeon Y, Kim J, Kim JH, Oh S, Battogtokh KE, Park MC, Sung YK, Kim S. Int. J. Biol. Sci. 2024 Oct 21;20(14):5764-5778.
Specific targeting of cancer vaccines to antigen-presenting cells via an endogenous TLR2/6 ligand derived from cysteinyl-tRNA synthetase 1. Kim HY, Cho S, Kim SB, Song EC, Jung W, Shin YG, Suh JH, Choi J, Yoon I, Kim U, Ban H, Hwang S, Mun J, Park J, Kim N, Lee Y, Kim MH, Kim S. Mol. Ther. 2024 Jul 25:S1525-0016(24)00469-6.
Disease association and therapeutic routes of aminoacyl-tRNA synthetases. Yoon I*, Kim U*, Choi J, Kim S. Trends Mol. Med. 2024 Jan;30(1):89-105.
2023
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1. Yoon I*, Kim S*, Cho M, You KA, Son J, Lee C, Suh JH, Bae DJ, Kim JM, Oh S, Park S, Kim S, Cho SH, Park S, Bang K, Seo M, Kim JH, Lee B, Park JS, Hwang KY, Kim S. EMBO Mol. Med. 2023 Jul 10;15(7):e16940.
EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell. Yoon I*, Song JA*, Suh JH, Kim S, Son J, Kim JH, Jang SY, Hwang KY, Kim MH, Kim S. Mol. Cell Biol. 2023;43(5):223-240.
2022
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. Kim K, Yoo HC, Kim BG, Kim S, Sung Y, Yoon I, Yu YC, Park SJ, Kim JH, Myung K, Hwang KY, Kim S, Han JM. Nat Commun. 2022 May 25;13(1):2904.
Functional and pathologic association of aminoacyl-tRNA synthetases with cancer. Sung Y*, Yoon I*, Han JM, Kim S. Exp Mol Med. 2022 May;54(5):553-566.
2021
Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants. Kim S, Yoon I, Kim S, Hwang KY. STAR Protoc. 2021 Jul 2;2(3):100642.
Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Kim S*, Yoon I*, Son J*, Park J, Kim K, Lee JH, Park SY, Kang BS, Han JM, Hwang KY, Kim S. Cell Rep. 2021 Apr 27;35(4):109031.
2020
Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1. Cho S, Kim SB, Lee Y, Song EC, Kim U, Kim HY, Suh JH, Goughnour PC, Kim Y, Yoon I, Shin NY, Kim D, Kim IK, Kang CY, Jang SY, Kim MH, Kim S. J Immunother Cancer. 2020 May;8(1):e000277.
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. Yoon I, Nam M, Kim HK, Moon HS, Kim S, Jang J, Song JA, Jeong SJ, Kim SB, Cho S, Kim Y, Lee J, Yang WS, Yoo HC, Kim K, Kim MS, Yang A, Cho K, Park HS, Hwang GS, Hwang KY, Han JM, Kim JH, Kim S. Science. 2020 Jan 10;367(6474):205-210.
2019
A threonyl-tRNA synthetase-mediated translation initiation machinery. Jeong SJ, Park S, Nguyen LT, Hwang J, Lee EY, Giong HK, Lee JS, Yoon I, Lee JH, Kim JH, Kim HK, Kim D, Yang WS, Kim SY, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S. Nat Commun. 2019 Mar 22;10(1):1357.
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1). Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J, Lee J. Bioorg Med Chem. 2019 Mar 15;27(6):1099-1109.
2018
Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. Bioorg Med Chem. 2018 Aug 7;26(14):4073-4079.
Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway. Lee M, Kim JH, Yoon I, Lee C, Fallahi Sichani M, Kang JS, Kang J, Guo M, Lee KY, Han G, Kim S, Han JM. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5279-E5288.
Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration. Jeong SJ, Kim JH, Lim BJ, Yoon I, Song JA, Moon HS, Kim D, Lee DK, Kim S. Exp Mol Med. 2018 Jan 12;50(1):e424.
2017
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S. Nat Commun. 2017 Sep 29;8(1):732.
Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. Yoon S, Kim JH, Koh Y, Tran PT, Ann J, Yoon I, Jang J, Kim WK, Lee S, Lee J, Kim S, Lee J. Bioorg Med Chem. 2017 Aug 1;25(15):4145-4152.
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. Kim SB, Kim HR, Park MC, Cho S, Goughnour PC, Han D, Yoon I, Kim Y, Kang T, Song E, Kim P, Choi H, Mun JY, Song C, Lee S, Jung HS, Kim S. J Cell Biol. 2017 Jul 3;216(7):2201-2216.
2016
Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers. Lee JH*, Zhao XM*, Yoon I*, Lee JY, Kwon NH, Wang YY, Lee KM, Lee MJ, Kim J, Moon HG, In Y, Hao JK, Park KM, Noh DY, Han W, Kim S. Cell Discov. 2016 Aug 30;2:16025.
Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor. Yoon S, Kim JH, Yoon I, Kim C, Kim SE, Koh Y, Jeong SJ, Lee J, Kim S, Lee J. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3038-3041.
2014
AIMP1 negatively regulates adipogenesis by inhibiting PPARγ. Kim JH, Lee JH, Park MC, Yoon I, Kim K, Lee M, Choi HS, Han JM, Kim S. J Cell Sci. 2014 Oct 15;127(Pt 20):4483-93.