Publications

Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer 

Jaekwang Jeong, Kwangmin Yoo, Jongwon Lee, Jae Hun Shin, Jungmin Choi, John Wysolmerski

Breast Cancer Research 27 (1), 85, 2025

Trogocytosis-mediated immune evasion in the tumor microenvironment 

Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred LM Bothwell, Jae Hun Shin

Experimental & Molecular Medicine 57, 1-12, 2025

Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution. 

Jaekwang Jeong, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Juhyeon Hong, Kwangmin Yoo, David G Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann M Haberman, Lark Kyun Kim, Shawn M Ferguson, Jungmin Choi, John Wysolmerski 

Cellular and Molecular Life Sciences 81, 29, 2024

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties 

Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K Dinesh, Stephen E Maher, Jeonghyun Kim, Soyeon Park, Jun Young Hong, John Wysolmerski, Jungmin Choi, Alfred LM Bothwell 

Elife 13:RP97279, 2024

Intercellular transfer of immune regulatory molecules via trogocytosis 

Soyeon Park, Jeonghyun Kim, Jae Hun Shin 

Intercellular and Interorganellar Transfer and Communication in Biology and Medicine, 131-146 , 2024

Flow goes forward and cells step backward: endothelial migration

Heon-Woo Lee, Jae Hun Shin, Michael Simons

Experimental & Molecular Medicine 54 (6), 711-719, 2022

Dickkopf proteins in pathological inflammatory diseases

Min Hee Park, Jae Hun Shin, Alfred LM Bothwell, Wook-Jin Chae

Journal of Leukocyte Biology 111 (4), 893-901, 2022

MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells

Jaekwang Jeong, Jae Hun Shin, Wenxue Li, Jun Young Hong, Jaechul Lim, Jae Yeon Hwang, Jean-Ju Chung, Qin Yan, Yansheng Liu, Jungmin Choi, John Wysolmerski

Cell reports 37 (13), 110160, 2021

Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis

Jae Hun Shin*, Jaekwang Jeong, Stephen E Maher, Heon-Woo Lee, Jaechul Lim, Alfred LM Bothwell*

Proceedings of the National Academy of Sciences 118 (48), e2110241118, 2021

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E Maher, Maria C Amezcua Vesely, WonJu Kim, Ja-Hyun Koo, Wenwen Tang, Dianqing Wu, Holly N Blackburn, Rosa M Xicola, Xavier Llor, Omer Yilmaz, Je-Min Choi, Alfred LM Bothwell

Iscience 24 (5), 102411, 2021

Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy

Kyungho Choi, Jaehun Shin, Sang-jin Lee, 2017

BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis

Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo, Jung-Ah Lee, Hye-Mi Kim, Hong-Jai Park, Do-Hyun Kim, Hong-Gyun Lee, Heeseok Yoon, Ji Yun Kim, Jae Hun Shin, Lark Kyun Kim, Junsang Doh, Hongtae Kim, Alfred L Bothwell, Sang-Kyou Lee, Minah Suh, Je-Min Choi

The Journal of Immunology 196 (1_Supplement), 139.7-139.7, 2016

Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy

Jae Hun Shin, Hyung Bae Park, Kyungho Choi

Immune Network 16 (2), 134-139, 2016

The Wnt antagonist Dickkopf-1 promotes pathological type 2 cell-mediated inflammation

Wook-Jin Chae, Allison K Ehrlich, Pamela Y Chan, Alexandra M Teixeira, Octavian Henegariu, Liming Hao, Jae Hun Shin, Jong-Hyun Park, Wai Ho Tang, Sang-Taek Kim, Stephen E Maher, Karen Goldsmith-Pestana, Peiying Shan, John Hwa, Patty J Lee, Diane S Krause, Carla V Rothlin, Diane McMahon-Pratt, Alfred LM Bothwell

Immunity 44 (2), 246-258, 2016

dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo, Jung-Ah Lee, Heeseok Yoon, Do-Hyun Kim, Hong-Jai Park, Hye-Mi Kim, Hong-Gyun Lee, Ji Yun Kim, Jae-Ung Lee, Jae Hun Shin, Lark Kyun Kim, Junsang Doh, Hongtae Kim, Sang-Kyou Lee, Alfred LM Bothwell, Minah Suh, Je-Min Choi

Nature communications 6 (1), 8244, 2015

Adenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response

Seung-Pil Shin, Hye-Hyun Seo, Jae-Hun Shin, Hyung-Bae Park, Dong-Pyo Lim, Hyeon-Seok Eom, Yong-Soo Bae, In-Hoo Kim, Kyungho Choi, Sang-Jin Lee

Molecular Therapy 21 (3), 688-695, 2013

Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models

Jae Hun Shin, Hyung Bae Park, Yu Mi Oh, Dong Pyo Lim, Ji Eun Lee, Hae Hyun Seo, Sang Jin Lee, Hyeon Seok Eom, In-Hoo Kim, Seung Hoon Lee, Kyungho Choi

Blood, The Journal of the American Society of Hematology 119 (24), 5678-5687, 2012

Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2

Yu Mi Oh, Hyung Bae Park, Jae Hun Shin, Ji Eun Lee, Ha Young Park, Dhong Hyo Kho, Jun Sung Lee, Heonsik Choi, Tomohiko Okuda, Koichi Kokame, Toshiyuki Miyata, In-Hoo Kim, Seung Hoon Lee, Ronald H Schwartz, Kyungho Choi

Nature communications 6 (1), 8698, 2015

Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation

Je-Min Choi, Jae-Hun Shin, Myung-Hyun Sohn, Martha J Harding, Jong-Hyun Park, Zuzana Tobiasova, Da-Young Kim, Stephen E Maher, Wook-Jin Chae, Sung-Ho Park, Chun-Geun Lee, Sang-Kyou Lee, Alfred LM Bothwell

Proceedings of the National Academy of Sciences 107 (43), 18575-18580, 2010

Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis

Je-Min Choi, Seung-Hyung Kim, Jae-Hoon Shin, Thomas Gibson, Byoung-Seok Yoon, Dong-Ho Lee, Seung-Kyou Lee, Alfred LM Bothwell, Jong-Soon Lim, Sang-Kyou Lee

Proceedings of the National Academy of Sciences 105 (50), 19875-19880, 2008