Embedded Files
2026
2026
Yang, Deok-Mo;‡ Kang, Yeo Wool;‡ Kim, Kwonwoo; Lee, Suk-Ho; Oh, Taegwon; Shin, Kye Jung; Kim, Myung Jin; Heo, Tae-Hwe;* Kim, Ikyon* "Discovery of novel indoline derivatives as potent small molecule PD-L1 inhibitors" Bioorganic & Medicinal Chemistry Letters 2026, 131,130458.
2025
2025
Ku, Dohui;‡ Lee, Sunhee;‡ Kim, Ikyon* "Exploring the Uncharted Indolizine Chemical Space: Construction of 5-Acylindolizines via a Domino Aldol-Vinylogous Aldol Process" Advanced Synthesis & Catalysis 2025, on line
Jung, Myungho;‡ Lee, Sunhee;‡ Ku, Dohui; Kang, Dageum; Kim, Ikyon* "Synthesis of poly-substituted imidazo[1,2-a]pyridines via a double annulation strategy" Asian Journal of Organic Chemistry 2025, 14(11), e70175.
Jeong, Yerin;‡ Kim, Sunmi;‡ Lee, Sunhee;‡ Ku, Dohui; Oh, Hyunjin; Kim, Ikyon* “[3+3] Annulative functionalization approaches to poly-functionalized 8-acylindolizines, 8-enylindolizines, and indolizine-coumarin hybrids” The Journal of Organic Chemistry 2025, 90(29), 10282-10315.
Ku, Dohui; Song, Seoyoung; Kim, Ikyon* “Regioselective double dehydrative cyclization route to polyheterocyclic skeletons consisting of 2,3-dihydroquinazolin-4(1H)-ones and 1,2-dihydropyrrolo[1,2-a]pyrazines” Organic & Biomolecular Chemistry 2025, 23(27), 6589-6602.
Lee, Sunhee; Nam, Seonghyeon; Kim, Ikyon* “One-pot three-component coupling access to indolizine-pyrrolodiazepine hybrid structures” Asian Journal of Organic Chemistry 2025, 14(6), e202500100.
La, Hyunhwa;‡ Kim, Jinwoong;‡ Kim, Dae-Hoon; Kim, Seong-Heon; Singh, Pargat; Nam, Gibeom; Moon, Kyeongwon;* Kim, Ikyon;* Kim, In Su* “Discovery of 1,4-disubstituted cyclohexene analogues as selective GPR119 agonists for the treatment of type 2 diabetes” Journal of Medicinal Chemistry 2025, 68(4), 4619-4634.
2024
2024
Oh, Hyunjin;‡ Ku, Dohui;‡ Jung, Myungho; Lee, Sunhee; Kim, Ikyon* “Catalyst-free construction of imidazole-pyrrolo[1,2-a]pyrazine hybrid, 2,6-disubstituted imidazo[1,2-a]pyrrolo[2,1-c]pyrazine via regioselective annulative functionalizations” The Journal of Organic Chemistry 2024, 89(24), 17966-17990.
Lee, Sunhee; Kim, Woojin; Kim, Ikyon* “Divergent annulation modes of (Z)-4-aryl-4-oxo-2-(pyridin-2-yl)but-2-enenitrile and methyl nitroacetate: selective access to 2-acyl-4H-quinolizin-4-one, isoxazole, and 2-acylindolizine” ACS Omega 2024, 9(36), 38126-38141.
Cha, Minhae;‡ Kim, Sunmi;‡ Jung, Euijin; Park, InWook; Yoon, Soljee; Ye, Suhyun; Lee, Songmin; Kim, JiMin; Kim, Hye Yun; Oh, Ji-Hoon; Maeng, Han-Joo; Kim, Ikyon;* Kim, YoungSoo* “Chemical-driven clearance of amyloid aggregates by poly-functionalized furo[2,3-b:4,5-b']dipyridine-chalcone hybrids to ameliorate memory in Alzheimer mouse model” Molecular Pharmaceutics 2024, 21(7), 3330-3342.
Lee, Yechan;‡ Lee, Sunhee,‡ Lee, Younho; Song, Doona; Park, So-Hyeon; Kim, Jieun; Namkung, Wan;* Kim, Ikyon* “Anticancer evaluation of novel benzofuran-indole hybrids as epithelial growth factor receptor inhibitors against non-small-cell lung cancer cells” Pharmaceuticals 2024, 17(2), 231.
Lee, Sunhee;‡ Lee, Yechan;‡ Namkung, Wan;* Kim, Ikyon* “Access to 8-aminoindolizine fused with quinone via Cu(OAc)2-catalyzed domino [4+2] annulation” Synthesis 2024, 56(11), 1799-1806.
Joshi, Dirgha Raj; Kim, Ikyon* “Recent advances in the synthesis of N-fused heterocycles from N-aroylmethylpyrrole-2-carboxaldehyde derivatives via annulative functionalization strategies” Tetrahedron 2024, 151, 133787.
Oh, Hyunjin; Kim, Ikyon* “Catalyst-free assembly of poly-functionalized 1,2,4-triazole-fused N-heterocycle, 6-acylated pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine” Organic & Biomolecular Chemistry 2024, 22(2), 320-336.
2023
2023
Lim, Bumhee;‡ Lee, Yeongcheol;‡ Kwon, Dah In; Kim, Seoyoung; Oh, Dong-Chan; Kim, Ikyon;* Lee, Jeeyeon* “Development of mitochondria-targeting photosensitizers via topoisomerase I inhibition” Asian Journal of Organic Chemistry 2023, 12, e202300476.
Cha, Minhae;‡ Dagar, Anuradha;‡ Lee, Sunhee; Cho, Illhwan; Lee, Donghee; Kim, Kyeonghwan; Park, InWook; Yoon, Soljee; Kim, Hye Yun; Kim, Ikyon;* Kim, YoungSoo* “Benzo[d]imidazole-pyrrolo[1,2-a]pyrazine hybrids ameliorate amyloid aggregates in the brain of Alzheimer transgenic mice” ACS Chemical Neuroscience 2023, 14(17), 3025-3034.
Oh, Hyunjin;‡ Kim, Hyeyeon;‡ Kim, Ikyon* “Regioselective access to 1,2,4-triazole-fused N-heterocycle, pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, via double dehydrative cyclizations” The Journal of Organic Chemistry 2023, 88(16), 11377-12164.
Lee, Songmin;‡ Dagar, Anuradha;‡ Cho, Illhwan; Kim, Kyeonghwan; Park, In Wook; Yoon, Soljee; Cha, Minhae; Shin, Jisu; Kim, Hye Yun; Kim, Ikyon;* Kim, YoungSoo* “4-Acyl-3,4-dihydropyrrolo[1,2-a]pyrazine derivative rescued the hippocampal-dependent cognitive decline of 5XFAD transgenic mice by dissociating soluble and insoluble Aβ aggregates” ACS Chemical Neuroscience 2023, 14(11), 2016-2026.
Jung, Euijin;‡Jeong, Yerin;‡Kim, Hyeyeon; Kim, Ikyon* “C3 Functionalization of indolizines via HFIP-promoted Friedel-Crafts reactions with (hetero)arylglyoxals” ACS Omega 2023, 8(18), 16131-16144.
Nam, Seonghyeon;‡ Lee, Sunhee;‡ Kim, Woojin;‡ Kim, Ikyon* “Divergent synthesis of two types of indolizines from pyridine-2-acetonitrile, (hetero)arylglyoxal, and TMSCN” Organic & Biomolecular Chemistry 2023, 21(18), 3881-3895.
Nam, Seonghyeon; Kim, Ikyon* “Cu-catalyzed Ullmann-type double C-N coupling approach to 5-aryl-5H-indolizino[3,2-b]indoles” The Journal of Organic Chemistry 2023, 88(1), 745-754.
2022
2022
Nam, Seonghyeon;‡ Lee, Yechan;‡ Park, So-Hyeon; Namkung, Wan;* Kim, Ikyon* “Synthesis and biological evaluation of a fused structure of indolizine and pyrrolo[1,2-c]pyrimidine: identification of its potent anticancer activity against liver cancer cells” Pharmaceuticals 2022, 15(11), 1395.
Lee, Hee Yang;‡ Yoon, Soljee;‡ Lee, Jeong Hwa;‡ Park, Keunwan; Jung, Youngeun; Cho, Illhwan; Lee, Donghee; Shin, Jisu; Kim, Kyeonghwan; Kim, Sunmi; Kim, Jimin; Kim, Koeun; Han, Seung Hoon; Kim, Seong Muk; Kim, Hye Ju; Kim, Hye Yun; Kim, Ikyon;* Kim, YoungSoo* “Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models” Alzheimer’s Research & Therapy 2022, 14, 177.
Joshi, Dirgha Raj; Kim, Ikyon* “Regioselective synthesis of 1-cyano-3-arylindolizines: construction of pyrroles via DDQ-mediated ring closure of cyclopropyl pyridines” Advanced Synthesis & Catalysis 2022, 364(17), 3016-3022.
Kim, Suzi;‡ Park, Jaehyun;‡ Joshi, Dirgha Raj;‡ Lee, Na Keum; Pham, Hang Le Bich; Chung, Linh Khanh; Kang, MinJoo; Kim, Younggwan; Kim, Ikyon;* Lee, Jeeyeon* “Benzofuro[2,3-c]isoquinolines as novel AIEgens: modulation of AIE characteristics by a single methoxy group” Dyes and Pigments 2022, 206, 110584.
Jeon, Dongkyu; Ryu, Kunhi; Jo, Sungwoo; Kim, Ikyon; Namkung, Wan* "VI-116, A novel potent inhibitor of VRAC with minimal effect on ANO1" International Journal of Molecular Sciences 2022, 23(9), 5168.
Lee, Yechan;‡ Joshi, Dirgha Raj;‡ Namkung, Wan;* Kim, Ikyon* "Generation of a poly-functionalized indolizine scaffold and its anticancer activity in pancreatic cancer cells” Bioorganic Chemistry 2022, 126, 105877.
2021
2021
Joshi, Dirgha Raj; Kim, Ikyon* “Synthesis of poly-functionalized indolizines via [5+1] annulative access to pyridines” Advanced Synthesis & Catalysis 2021, 363(23), 5330-5335. (2021.12.07)
Jung, Kilsoo; Kim, Sunmi; Choi, Seonghwi; Kim, Ikyon;* Han, Gyoonhee* “Development of a DABCO-succinic acid based catalytic system for aza-Michael addition and aza-Michael/Knoevenagel tandem reaction of thiazolidine-2,4-dione to electron deficient alkenes” The Journal of Organic Chemistry 2021, 86(23), 16785-16794. (2021.12.03)
Kim, Kyeonghwan;‡ Lee, Jeong Hwa;‡ Kim, Sunmi; Lee, Songmin; Lee, Donghee; Kim, Hye Yun; Kim, Ikyon;* Kim, YoungSoo* “Anti-amyloidogenic indolizino[3,2-c]quinolines as imaging probes differentiating dense-core, diffuse, and coronal plaques of amyloid-β” RSC Medicinal Chemistry 2021, 12, 1926-1934. (2021.11.01)
Lee, Sunhee;‡ Kim, Sunmi;‡ Yoon, Seok Hyun; Dagar, Anuradha; Kim, Ikyon* “Diastereoselective synthesis of densely functionalized 3a,8a-dihydro-8H-furo[3,2-a]pyrrolizines through one-pot three-component assembly” The Journal of Organic Chemistry 2021, 86(17), 12367-12377. (2021.09.03)
Joshi, Dirgha Raj; Kim, Ikyon* “Michael-aldol double elimination cascade to make pyridines: use of chromone for the synthesis of indolizines” The Journal of Organic Chemistry 2021, 86(15), 10235-10248. (2021.08.06)
Lee, Jeong Hwa;‡ Yoon, Seok Hyun;‡ Nam Seonghyeon; Kim, Ikyon* “One-pot three-component coupling access to 1,2-dihydropyrrolo[1,2-a]pyrazine-1-phosphonates: multi-functionalization of pyrazine unit” Organic & Biomolecular Chemistry 2021, 19(27), 6066-6084. (2021.07.21) (‡: co-first authors)
Kim, Sunmi;‡ Lee, Jeong Hwa;‡ Yoon, Seok Hyun;‡ Kim, Ikyon* “A regioselective [4+2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines” Organic & Biomolecular Chemistry 2021, 19(26), 5806-5817. (2021.07.14) (‡: co-first authors)
Lee, Younho;‡ Kim, Hyunkyung;‡ Kim, Haelee;‡ Cho, Ha Yeon; Jee, Jun-Goo; Seo, Kyung-Ah; Son, Jung Beom; Ko, Eunhwa; Choi, Hwan Geun; Kim, Nam Doo;* Kim, Ikyon* “X-ray crystal structure-guided design and optimization of 7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile scaffold as a potent and orally active monopolar spindle 1 inhibitor” Journal of Medicinal Chemistry 2021, 64(10), 6985-6995. (2021.05.27) (‡: co-first authors)
Prasad, Sure Siva;‡ Joshi, Dirgha Raj;‡ Kim, Ikyon* “Facile access to 3,4-disubstituted 2H-chromenes via domino [4+2] annulation” Synthesis 2021, 53(08), 1503-1512. (2021.04) (‡: co-first authors)
Prasad, Sure Siva;‡ Joshi, Dirgha Raj;‡ Kim, Ikyon* “BF3-OEt2-catalyzed one-pot three-component access to diarylmethylazides” Tetrahedron Letters 2021, 67, 152820. (2021.03.16) (‡: co-first authors)
Kim, Sung June; Lee, Sunhee; Kim, Ikyon* “Regioselective functionalization of N-fused heteroaromatics via FeCl3-catalyzed nucleophilic addition to activated N-heterocycles” Synthesis 2021, 53(05), 943-953. (2021.03)
Park, Jaehyun;‡ Lee, Ji Hye;‡ Lim, Bumhee; Lee, Na Keum; Sim, Gyuseok; Ryu, Seol; Kim, Ikyon; Hwang, Hyonseok;* Lee, Jeeyeon* “Fine tuning of the HOMO-LUMO gap of 6-(thiophen-2-yl)indolizino[3,2-c]quinolines and their self-assembly to form fluorescent organic nanoparticles: rational design and theoretical calculations” ChemPhotoChem 2021, 5(1), 58-67. (2021.01) (‡: co-first authors)
Kim, DaWon;‡ Bae, Gi Hun;‡ Kim, Hye Yun; Jeon, Hanna; Kim, Kyeonghwan; Shin, Jisu; Lee, Sunhee; Hong, Seungpyo; Kim, Ikyon;* Kim, YoungSoo* “Orally administered benzofuran derivative disaggregated Aβ plaques and oligomers in the brain of 5XFAD Alzheimer transgenic mouse” ACS Chemical Neuroscience 2021, 12(1), 99-108. (2021.01.06) (‡: co-first authors)
2020
2020
Dagar, Anuradha; Kim, Ikyon* “Expansion of diazepine heterocyclic chemical space via sequential Knoevenagel condensation-intramolecular aza-Wittig reaction: 2-acyl-4-aryl-5H-pyrrolo[1,2-d][1,4]diazepines” Organic & Biomolecular Chemistry 2020, 18(48), 9836-9851. (2020.12.28)
Kim, DaWon;‡ Lee, Jeong Hwa;‡ Shin, Jisu; Kim, Kyeonghwan; Lee, Sejin; Kim, Hye Yun; Kim, Ikyon;* Kim, YoungSoo* “Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model” PLOS ONE 2020, 15(12), e0243041. (2020.12.23) (‡: co-first authors)
Yoon, Seok Hyun; Kim, Sung June; Kim, Ikyon* “One-pot four-component coupling approach to polyheterocycles: 6H-furo[3,2-f]pyrrolo[1,2-d][1,4]diazepine” The Journal of Organic Chemistry 2020, 85(23), 15082-15091. (2020.12.04)
Prasad, Sure Siva; Joshi, Dirgha Raj; Lee, Jeong Hwa; Kim, Ikyon* “One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical spaces” Organic & Biomolecular Chemistry 2020, 18(40), 8119-8140. (2020.10.28)
Dagar, Anuradha; Joshi, Dirgha Raj; Kim, Ikyon* “Solvent-controlled divergent syntheses of polycyclic N-fused heteroaromatics” Synthesis 2020, 52(19), 2841-2856. (2020.10)
Kim, Jinhwang; Cha, Hyeon-Min; Park, Mikyung; Singh, Dileep Kumar; Bae, Gi Hun; Kim, Seong Hwan;* Kim, Ikyon* “Expanding the chemical space: discovery of new anticancer 3-arylbenzofuran derivatives” Journal of Heterocyclic Chemistry 2020, 57(9), 3279-3293. (2020.09)
Joshi, Dirgha Raj;‡ Seo, Yohan;‡ Heo, Yunkyung; Park, So-hyeon; Lee, Yechan; Namkung, Wan;* Kim, Ikyon* “Domino [4+2] annulation access to quinone-indolizine hybrids: anticancer N-fused polycycles” The Journal of Organic Chemistry 2020, 85(16), 10994-11005. (2020.08.21) (‡: co-first authors)
Singh, Dileep Kumar;‡ Kim, Suzi;‡ Lee, Jeong Hwa; Lee, Na Keum; Kim, Jinwoo; Lee, Jeeyeon; Kim, Ikyon* “6-(Hetero)arylindolizino[1,2-c]quinolines as highly fluorescent chemical space: synthesis and photophysical properties” Journal of Heterocyclic Chemistry 2020, 57(8), 3018-3028. (2020.08) (‡: co-first authors)
Seo, Yohan;‡ Choi, Jiwon;‡ Lee, Jeong Hwa;‡ Kim, Tae Gun; Park, So-hyeon; Han, Gyoonhee; Namkung, Wan;* Kim, Ikyon* “Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: discovery of novel potent ANO1 inhibitors” Bioorganic Chemistry 2020, 101, 104000. (2020.08) (‡: co-first authors)
Dagar, Anuradha; Seo, Yohan; Namkung, Wan; Kim, Ikyon* “Domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units” Organic & Biomolecular Chemistry 2020, 18(17), 3324-3333. (2020.05.07)
Park, Jaehyun;‡ Lim, Bumhee;‡ Lee, Na Keum; Lee, Ji Hye; Jang, Kyungkuk; Kang, San Won; Kim, Suzi; Kim, Ikyon; Hwang, Hyonseok; Lee, Jeeyeon* “Dual-functioning IQ-LVs as red-emissive lysosomal viscosity probes and inhibitors of autophagic flux” Sensors and Actuators B: Chemical 2020, 309, 127764. (2020.04.15) (‡: co-first authors)
Bae, Gi Hun;‡ Kim, Suzi;‡ Lee, Na Keum; Dagar, Anuradha; Lee, Jeong Hwa; Lee, Jeeyeon;* Kim, Ikyon* “Facile approach to benzo[d]imidazole-pyrrolo[1,2-a]pyrazine hybrid structures through double cyclodehydration and aromatization and their unique optical properties with blue emission” RSC Advances 2020, 10(12), 7265-7288. (2020.02) (‡: co-first authors)
Seo, Yohan;‡ Lee, Jeong Hwa;‡ Park, So-hyeon; Namkung, Wan;* Kim, Ikyon* “Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: synthesis and its anticancer activity in prostate cancer and breast cancer cells” European Journal of Medicinal Chemistry 2020, 188, 111988. (2020.02.15) (‡: co-first authors)
2019
2019
Lim, Bumhee;‡ Baek, Byungyeob;‡ Jang, Kyungkuk; Lee, Na Keum; Lee, Ji Hye; Lee, Yeongcheol; Kim, Jinwoo; Kang, San Won; Park, Jaehyun; Kim, Suzi; Kang, Nae-Won; Hong, Suckchang; Kim, Dae-Duk; Kim, Ikyon; Hwang, Hyonseok; Lee, Jeeyeon* “Novel turn-on fluorescent biosensors for selective detection of cellular Fe3+ in lysosomes: thiophene as a selectivity-tuning handle for Fe3+ sensors” Dyes and Pigments 2019, 169, 51-59. (2019.10) (‡: co-first authors)
Shin, Naewoo Neo;‡ Jeon, Hanna;‡ Jung, Youngeun;‡ Baek, Seungyeop; Lee, Sejin; Yoo, Hee Chan; Bae, Gi Hun; Park, Keunwan; Yang, Seung-Hoon; Han, Jung Min; Kim, Ikyon;* Kim, YoungSoo* “Fluorescent 1,4-naphthoquinones visualize diffuse and dense-core amyloid plaques in APP/PS1 transgenic mouse brains” ACS Chemical Neuroscience 2019, 10(6), 3031-3044. (2019.06.19) (‡: co-first authors)
Dagar, Anuradha; Bae, Gi Hun; Lee, Jeong Hwa; Kim, Ikyon* “Tandem [4+1+1] annulation approach to 4-acyl-3,4-dihydropyrrolo[1,2-a]pyrazines: diastereoselective construction of dihydropyrazine units from pyrroles” The Journal of Organic Chemistry 2019, 84(11), 6916-6927. (2019.06.07)
Kim, Jinwoo;‡ Park, Mikyung;‡ Choi, Jiwon; Singh, Dileep Kumar; Kwon, Ho Jeong;* Kim, Seong Hwan;* Kim, Ikyon* “Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives” Bioorganic & Medicinal Chemistry Letters 2019, 29(11), 1350-1356. (2019.06.01) (‡: co-first authors)
Prasad, Sure Siva; Singh, Dileep Kumar; Kim, Ikyon* “One-pot, three-component approach to diarylmethylphosphonates: a direct entry to polycyclic aromatic systems” The Journal of Organic Chemistry 2019, 84(10), 6323-6336. (2019.05.17)
Singh, Dileep Kumar;‡ Jang, Kyungkuk;‡ Kim, Jinhwang; Lee, Jeeyeon;* Kim, Ikyon* “Intramolecular electrophilic cyclization approach to 6-substituted naphtho[2,1-b]benzofuran: novel dual-state emissive fluorophores with blue emission” ACS Combinatorial Science 2019, 21(5), 408-416. (2019.05.13) (‡: co-first authors)
Singh, Dileep Kumar;‡ Prasad, Sure Siva;‡ Kim, Jinhwang; Kim, Ikyon* “One-pot, three-component approach to diarylacetonitriles” Organic Chemistry Frontiers 2019, 6(5), 669-673. (2019.03.07) (‡: co-first authors)
Singh, Dileep Kumar; Kim, Ikyon* “Convergent synthesis of diptoindonesin G” Tetrahedron Letters 2019, 60(3), 300-301. (2019.01.17)
Singh, Dileep Kumar; Kim, Ikyon* “Electrophilic acetylation and formylation of pyrrolo[1,2-a]pyrazines: substituent effects on regioselectivity” ARKIVOC 2019, part iii, 8-21. (2019.01.12)
2018
2018
Seo, Yohan;‡ Kim, Jinhwang;‡ Chang, Jiwon; Kim, Seong Soon; Namkung, Wan;* Kim, Ikyon* “Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors” European Journal of Medicinal Chemistry 2018, 160, 245-255. (2018.12.05) (‡: co-first authors)
Lee, Wonsik; Kim, Dongjun; Lim, Joonyoung; Kim, Geonho; Kim, Ikyon;* Kim, Songkuk;* Kim, Jiwon* “Light-induced electrical switch via photo-responsive nanocomposite film” Sensors and Actuators B: Chemical 2018, 266, 724-729. (2018.08.01)
Kim, Won-Serk; Kim, Wang-Kyun; Choi, Nahyun; Suh, Wonhee; Lee, Jinu; Kim, Dae-Duk; Kim, Ikyon;* Sung, Jong-Hyuk* “Development of S-methylmethionine sulfonium derivatives and their skin-protective effect against ultraviolet exposure” Biomolecules & Therapeutics 2018, 26(3), 306-312. (2018.05)
Kwon, Soonbum; Lee, Yeongcheol; Jung, Youngeun; Kim, Ju Hee; Baek, Byungyeob; Lim, Bumhee; Lee, Jungeun; Kim, Ikyon; Lee, Jeeyeon* “Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity” European Journal of Medicianl Chemistry 2018, 148, 116-127. (2018.03.25)
Maruta, Hiroshi;* Park, Sang-Kyu; Ahn, Mok-Ryeon; Kim, Ikyon “PAK1-blockers (natural and synthetic) that promote the longevity and heat-endurance” Current Trends in Medicinal Chemistry 2018, 1(1), 1002. (2018.02)
Singh, Dileep Kumar; Kim, Jinwoo; Sung, Jong-Hyuk; Kim, Ikyon* “Total syntheses of biologically active pterocarpan, isoflavan, and isoflavanone from Dalbergia oliveri” Bulletin of the Korean Chemical Society 2018, 39(2), 239-243. (2018.02)
Singh, Dileep Kumar; Kim, Ikyon* “Skeletal reorganization: synthesis of diptoindonesin G from pauciflorol F” J. Org. Chem. 2018, 83(3), 1667-1672. (2018.02.02)
Park, Sujin;‡ Kim, Eun Hye;‡ Kim, Jinwoo; Kim, Seong Hwan;* Kim, Ikyon* “Biological evaluation of indolizine-chalcone hybrids as new anticancer agents” European Journal of Medicinal Chemistry 2018, 144, 435-443. (2018.01.20) (‡: co-first authors)
Kim, Jinwoo; Kim, Ikyon* “Design and synthesis of a hybrid framework of indanone and chromane: total synthesis of a homoisoflavanoid, brazilane” Organic & Biomolecular Chemistry 2018, 16(1), 89-100. (2018.01.07)
2017
2017
Moon, Seong-Hee; Kim, Ikyon;* Kim, Seong Hwan* “Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway” Archives of Pharmacal Research 2017, 40(11), 1328-1335. (2017.11)
Kwon, Soonbum; Kwon, Dah In; Jung, Youngeun; Kim, Ju Hee; Lee, Yeongcheol; Lim, Bumhee; Kim, Ikyon; Lee, Jeeyeon* “Indolizino[3,2-c]quinoline as environment-sensitive fluorescent light-up probes for targeted live cell imaging” Sensors and Actuators B: Chemical 2017, 252, 340-352. (2017.11)
Kim, Jinwoo;‡ Heo, Yunkyung;‡ Jung, Youngeun; Lee, Jinu;* Kim, Ikyon* “Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction” Tetrahedron 2017, 73(39), 5759-5768. (2017.09.28) (‡: co-first authors)
Nayak, Maloy; Singh, Dileep Kumar; Kim, Ikyon* “Regiospecific synthesis of 5- and 6-acylated naphtho[1,2-b]benzofurans via intramolecular alkyne carbonyl metathesis” Synthesis 2017, 49(9), 2063-2073. (2017.05.01)
Yoon, Sukhyun; Jung, Youngeun; Kim, Ikyon* “Catalyst-free synthesis of 4-alkynylazobenzenes from quinols” Tetrahedron Letters 2017, 58(16), 1590-1591. (2017.04.19)
Nayak, Maloy; Singh, Dileep Kumar; Kim, Ikyon* “Polyaromatic heterocycles through intramolecular alkyne carbonyl metathesis: 5-acylnaphtho[2,1-b]benzofurans” Tetrahedron 2017, 73(14), 1831-1840. (2017.04.06)
Singh, Dileep Kumar; Jung, Youngeun; Kim, Ikyon* “Total syntheses of urgineanins A, B, D, and their analogues” Synthesis 2017, 49(7), 1531-1537. (2017.04.01)
Nayak, Maloy; Kang, Young Kee;* Kim, Ikyon* “Altering the cyclization modes: temperature-dependent intramolecular 7-endo-dig vs. 6-endo-dig electrophilic ring closures” Organic Letters 2017, 19(6), 1474-1477. (2017.3.17)
2016
2016
Jung, Youngeun;‡ Singh, Dileep Kumar;‡ Kim, Ikyon* “Symmetry-based approach to oligostilbenoids: rapid entry to viniferifuran, shoreaphenol, malibatol A, and diptoindonesin G” Beilstein Journal of Organic Chemistry 2016, 12, 2689-2693. (2016.12.12) (‡: co-first authors)
Jung, Youngeun; Kim, Ikyon* “Chemoselective reduction of quinols as an alternative to Sonogashira coupling: synthesis of polysubstituted benzofurans” Organic & Biomolecular Chemistry 2016, 14(44), 10454-10472. (2016.11.28)
Nayak, Maloy; Jung, Youngeun; Kim, Ikyon* “Syntheses of pterocarpenes and coumestans via regioselective cyclodehydration” Organic & Biomolecular Chemistry 2016, 14(34), 8074-8087. (2016.09.14)
Kim, Won-Serk;‡ Kim, Ikyon;‡ Kim, Wang-Kyun; Choi, Ju-Yeon; Kim, Doo Young; Moon, Sung-Guk; Min, Hyung Keun; Song, Min-Kyu; Sung, Jong-Hyuk* “Mitochondria-targeted vitamin E protects skin from UVB-irradiation” Biomolecules & Therapeutics 2016, 24(3), 305-311. (2016.05) (‡: co-first authors)
Kim, Eunji; Son, Young-Jin; Yang, Yanyan; Shen, Ting; Kim, Ikyon; Aravinthan, Adithan; Kim, Jong-Hoon;* Cho, Jae Youl* “1-(2,3-Dibenzimidazole-2-ylpropyl)-2-methoxybenzene is a Syk inhibitor with anti-inflammatory properties” Molecules 2016, 21(4), 508. (2016.04)
Jung, Youngeun; Kim, Ikyon* “Synthesis of 6-aryl-5-iodobenzo[e]pyrido[1,2-a]indoles via 6-endo-dig iodocylization” Asian Journal of Organic Chemistry 2016, 5(1), 147-152. (2016.01)
Moon, Seong-Hee;‡ Jung, Youngeun;‡ Kim, Seong Hwan;* Kim, Ikyon* “Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53” Bioorganic & Medicinal Chemistry Letters 2016, 26(1), 110-113. (2016.01.01) (‡: co-first authors)
2015
2015
Zhao, Zibo; Wang, Lu; James, Taryn; Jung, Youngeun; Kim, Ikyon; Tan, Renxiang; Hoffmann, Michael; Xu, Wei* “Reciprocal regulation of ERα and ERβ stability and activity by diptoindonesin G” Chemistry & Biology 2015, 22(12), 1608-1621. (2015.12.17)
Jung, Youngeun; Kim, Ikyon* “C3 Functionalization of indolizines via In(III)-catalyzed three-component reaction” Organic & Biomolecular Chemistry 2015, 13(45), 10986-10994. (2015.12.07)
Nayak, Maloy; Kim, Ikyon* “Alkyne carbonyl metathesis as a means to make 4-acyl chromenes: syntheses of (±)-deguelin and (±)-munduserone” J. Org. Chem. 2015, 80(22), 11460-11467. (2015.11.20)
Nayak, Maloy; Kim, Ikyon* “Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines, via alkyne-carbonyl metathesis” Organic & Biomolecular Chemistry 2015, 13(37), 9697-9708. (2015.10.07)
Jung, Youngeun; Kim, Ikyon* “Deformylative intramolecular hydroarylation: synthesis of benzo[e]pyrido[1,2-a]indoles” Org. Lett. 2015, 17(18), 4600-4603. (2015.09.18)
Park, Sujin; Kwon, Dah In; Lee, Jeeyeon;* Kim, Ikyon* “When indolizine meets quinoline: diversity-oriented synthesis of new polyheterocycles and their optical properties” ACS Comb. Sci. 2015, 17(8), 459-469. (2015.08.10)
Kim, Won-Serk; Seo, Hyun-Min; Kim, Wang-Kyun; Choi, Joon-Seok; Kim, Ikyon; Sung, Jong-Hyuk* “The photoprotective effect of S-methylmethionine sulfonium in skin” International Journal of Molecular Sciences 2015, 16(8), 17088-17100. (2015.08)
Jung, Youngeun; Kim, Ikyon* “Concise synthetic approach to brazilin via Pd-catalyzed allylic arylation” Organic & Biomolecular Chemistry 2015, 13(14), 4331-4335. (2015.04.14)
Park, Sujin; Kim, Ikyon* “Electron withdrawing group effect in aryl group of allyl bromides for the successful synthesis of indolizines via a novel [3+3] annulation approach” Tetrahedron 2015, 71(13), 1982-1991. (2015.04.01)
Jung, Youngeun; Kim, Ikyon* “Total synthesis of brazilin” J. Org. Chem. 2015, 80(3), 2001-2005. (2015.02.06)
Baek, Jong Min; Kim, Ju-Young; Jung, Youngeun; Moon, Seong-Hee; Choi, Min Kyu; Kim, Seong Hwan; Lee, Myeung Su; Kim, Ikyon*; Oh, Jaemin* “Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo” Phytomedicine 2015, 22(1), 27-35. (2015. 01.15)
2012 - 2014
2012 - 2014
Park, Sujin; Jung, Youngeun; Kim, Ikyon* “Diversity-oriented decoration of pyrrolo[1,2-a]pyrazines” Tetrahedron 2014, 70(41), 7534-7550. (2014.10.14)
Lee, Jin Ho; Kim, Myungock; Kim, Ikyon* “Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-disubstituted benzofurans” J. Org. Chem. 2014, 79(13), 6153-6163. (2014.07.03)
Kim, Myungock; Jung, Youngeun; Kim, Ikyon* “Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units” J. Org. Chem. 2013, 78(20), 10395-10404. (2013.10.18)
Lee, Jin Ho; Kim, Ikyon* “Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit” J. Org. Chem. 2013, 78(3), 1283-1288. (2013.02.01)
Jung, Youngeun; Kim, Ikyon* "Facile approach to diverse 3-acylated indolizines via a sequential Sonogashira coupling/iodocyclization process" Tetrahedron 2012, 68(39), 8198-8206. (2012.09. 30)
Cho, Hanyang; Kim, Ikyon* "Palladium-catalyzed construction of poly-substituted indolizinones" Tetrahedron 2012, 68(27-28), 5464-5480. (2012.07.08)
1994 - 2013
1994 - 2013
Lee, Sun Hee; Kim, Ikyon; Kim, Seong Hwan* “Anti-resorptive and anabolic activity of 3-(3,5-dimethoxyphenyl)-6-methoxybenzofuran-4-carboxylate” Bull. Korean Chem. Soc. 2011, 32(11), 4137-4140. (2011.11.20)
Mao, Gaowei; Kraus, George A.; Kim, Ikyon; Spurlock, Michael E.; Bailey, Theodore B.; Beitz, Donald C.* “Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice” British Journal of Nutrition 2011, 106(1), 87-95. (2011.07.14)
Kim, Kyungsun; Kim, Ikyon* “Total synthesis of diptoindonesin G via a highly efficient domino cyclodehydration/intramolecular Friedel-Crafts acylation/regioselective demethylation sequence” Org. Lett. 2010, 12(22), 5314-5317. (2010.11.19)
Mao, Gaowei; Kraus, George A.; Kim, Ikyon; Spurlock, Michael E.; Bailey, Theodore B.; Zhang, Qijing; Beitz, Donald C.* “A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice” Journal of Nutrition 2010, 140(8), 1425-1431. (2010.08.01)
Kim, Ikyon*; Kim, Kyungsun “Expeditious synthesis of highly substituted indolizinones via a palladium-catalyzed domino sequence” Org. Lett. 2010, 12(11), 2500-2503. (2010.06.04)
Kim, Kyungsun; Kim, Ikyon* “Diversity-oriented construction of highly substituted indolizinones” J. Comb. Chem. 2010, 12(3), 379-382. (2010.05.10)
Kim, Ikyon; Song, Jong Hwan; Park, Chang Min; Jeong, Joon Won; Kim, Hyung Rae; Ha, Jin Ryul; No, Zaesung; Hyun, Young-Lan; Cho, Young Sik; Kang, Nam Sook*; Jeon, Dong Ju* “Design, synthesis, and evaluation of 2-aryl-7-(3’,4’-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors” Bioorg. Med. Chem. Lett. 2010, 20(3), 922-926. (2010.02.01)
Jung, Eun Joo; Hur, Minkyu; Kim, Young Lim; Lee, Ge Hyeong; Kim, Jeongmin; Kim, Ikyon; Lee, Min Woo; Han, Ho-Kyun; Kim, Mi-Soon; Hwang, Sejin; Kim, Sungjoo; Woo, A Mi; Yoon, Yeup; Park, Heon Jin; Won, Jonghwa* “Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model” The Journal of Pharmacology and Experimental Therapeutics 2009, 331(3), 1005-1013. (2009.12.01)
Kim, Ikyon*; Kim, Kyungsun; Choi, Jungeun “A direct approach to 5-hydroxybenzofurans via a platinum-catalyzed domino rearrangement/5-endo-dig cyclization reaction of quinols” J. Org. Chem. 2009, 74(21), 8492-8495. (2009.11.06)
Kim, Ikyon*; Choi, Jihyun “A versatile approach to oligostilbenoid natural products - synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol” Org. Biomol. Chem. 2009, 7(13), 2788-2795. (2009.07.07)
Kang, Nam Sook; Lee, Gil Nam; Kim, Chi Hyun; Bae, Myung Ae; Kim, Ikyon; Cho, Young Sik* “Identification of small molecules that inhibit GSK-3b through virtual screening” Bioorg. Med. Chem. Lett. 2009, 19(2), 533-537. (2009.01.15)
Kim, Ikyon*; Lee, Sei-Hee; Lee, Sunkyung “BCl3-promoted synthesis of benzofurans” Tetrahedron Letters 2008, 49(46), 6579-6584. (2008.11.10)
Kim, Ikyon*; Choi, Jihyun; Lee, Sunkyung; Lee, Ge Hyeong “A highly efficient catalyst-free cycloisomerization approach to indolizinones” Synlett 2008, (15), 2334-2338. (2008.09)
Song, Jong Hwan; Kim, Sun Gi; No, Zae Sung; Hyun, Young-Lan; Jeon, Dong Ju*; Kim, Ikyon* “Discovery and synthesis of novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors” Bull. Korean Chem. Soc. 2008, 29(8), 1467-1471. (2008.08.20)
Kim, Ikyon*; Na, Hee-Kyung; Kim, Kyung Ran; Kim, Sun Gi; Lee, Ge Hyeong “A novel [3+2] dipolar cycloaddition approach to hexahydrobenzofuro[3,2-b]pyrroles” Synlett 2008, (13), 2069-2071. (2008.08)
Jeon, Dong Ju*; Kim, Ikyon “Twist boat conformation of thiane S-oxide both in solid state and in solution” Bull. Korean Chem. Soc. 2008, 29(7), 1369-1373. (2008.07.20)
Choi, Jihyun; Lee, Ge Hyeong; Kim, Ikyon* “Efficient synthesis of highly substituted indolizinones via iodocyclization/1,2-shift” Synlett 2008, (8), 1243-1249. (2008.05)
Kim, Ikyon*; Kim, Sun Gi; Choi, Jihyun; Lee, Ge Hyeong “Facile synthesis of benzo-fused 2,8-dioxabicyclo[3.3.1]nonane derivatives via a domino Knoevenagel condensation/hetero-Diels-Alder reaction sequence” Tetrahedron 2008, 64(4), 664-671. (2008.01.21)
Kim, Ikyon*; Kim, Sun Gi; Kim, Ji Young; Lee, Ge Hyeong “A novel approach to 3-acylated indolizine structures via iodine-mediated hydrative cyclization” Tetrahedron Letters 2007, 48(51), 8976-8981. (2007.12.17)
Kim, Ikyon*; Won, Hye Kyoung; Choi, Jihyun; Lee, Ge Hyeong “A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization” Tetrahedron 2007, 63(52), 12954-12960. (2007.12.24)
Kim, Ikyon*; Choi, Jihyun; Won, Hye Kyoung; Lee, Ge Hyeong “Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization” Tetrahedron Letters 2007, 48(39), 6863-6867. (2007.09.24)
Kim, Ikyon*; Lee, Ge Hyeoung; No, Zae Sung “Direct Access to various 1-substituted-imidazo[1,5-a]pyridine-3(2H)-thione derivatives” Bull. Korean Chem. Soc. 2007, 28(4), 685-688. (2007.04.20)
Keller, Valerie A.; Kim, Ikyon; Burke, Steven D.* “Synthetic efforts toward the C22-C36 subunit of halichondrin B utilizing local and imposed symmetry” Organic Letters 2005, 7(4), 737-740. (2005.02.17)
Kraus, George A.*; Kim, Ikyon; Kesavan, Sarathy “The reaction of 4-methoxybenzylmagnesium chloride with aldehydes. The formation of 4-exomethylenecyclohexenones” Tetrahedron Letters 2004, 45(37), 6839-6840. (2004.09.06)
Kraus, George A.*; Kim, Ikyon “A direct route to isoflavanquinones: the synthesis of colutequinones A and B” Tetrahedron 2003, 59(40), 7935-7937. (2003.09.29)
Kraus, George A.*; Kim, Ikyon “A direct synthesis of O-methyl claussequinone” The Journal of Organic Chemistry 2003, 68(11), 4517-4518. (2003.05.30)
Kraus, George A.*; Kim, Ikyon “A synthetic approach to malibatol A” Organic Letters 2003, 5(8), 1191-1192. (2003.04.17)
Kim, Moohi Yoo*; Lim, Geun Jho; Lim, Joong In; Kim, Dong Sung; Kim, Ik Yon; Yang, Jae Sung “An efficient process of ondansetron synthesis” Heterocycles 1997, 45(10), 2041-2043. (1997.09.01)
Kim, Moohi Yoo*; Yoon, Suk Kyoon; Lim, Geun Jho; Shin, Hyun Tae; Cho, Hyun Ook; Kim, Ik Yon; Park, Sang Goog; Lim, Tae Kyun; Kim, Hee Kee “Synthesis, biological properties and structure-activity relationships of 2-oxoquinoline derivatives, new nonpeptide angiotensin II receptor antagonists” Korean Journal of Medicinal Chemistry 1995, 5(1), 28-37. (1995.02.20)
Lim, Geun Jho*; Yoon, Suk Kyoon; Kim, Moohi Yoo; Cho, Hyun Ook; Kim, Ik Yon; Shin, Hyun Tae; Park, Sang Goog; Son, Moon Ho; Kim, Soon Hoe “Synthesis of 5H,7H-dibenzo[c,e]thiepin derivatives as potential antihypertensive agents” Korean Journal of Medicinal Chemistry 1995, 5(1), 13-27. (1995.02.20)
Kim, Deukjoon*; Shin, Kye Jung; Kim, Ik Yoen; Park, Sang Woo “A total synthesis of (-)-reiswigin A via sequential Claisen rearrangement-intramolecular ester enolate alkylation” Tetrahedron Letters 1994, 35(43) 7957-7960. (1994.10.24)
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