Publications

Published articles

19) Kychygina A., Dall’Osto M., Allen J.A.M., Cadoret J-C., Piras V., Pickett H.A., and Crabbe L. (2021): Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools. Scientific Reports (In press).

18) Umlauf, D., Sobecki, M. and Crabbe, L. (2020). Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions. Methods in Molecular Biology 2175, 123-138.

17) Masamsetti, V.P., Mak, K.S., Low, R., Riffikin, C., Lamm, N., Crabbe, L., Karlseder, J., Huang, D., Hayashi, M., Cesare, A. (2019). Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nature Communications 10, 4224.

16) Sobecki, M., Boulay, J., Souaid, C., Noordermeer, D., and , Crabbe, L. (2018). The versatile MadID approach allows mapping of protein-DNA interactions and highlights telomere-nuclear envelope contact sites. Cell Reports 25, 2891-2903.

15) Pardo, B., Crabbe, L., and Pasero, P. (2017). Signaling Pathways of Replication Stress in Yeast. FEMS Yeast Res. 17, 101-111.

14) Sobilo, L., Kurfürst, R., Loubens, V., Martin, M., Mondon, P., Jeanneton, O., Heusèle, C., Ossant, F., Lespessailles, E., Toumi, H., Crabbe, L.*, and Schnebert, S*. (2015). Impact of exogenous stress on TGF-β inducible early gene 1 in human skin cells. Exp. Dermatol. 24, 892-894.

13) Cesare, A.J., Hayashi, M.T., Crabbe, L., and Karlseder, J. (2013). The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell 51, 141–155.

12) Crabbe, L., Cesare, A.J., Kasuboski, J.M., Fitzpatrick, J.A.J., and Karlseder, J. (2012). Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep. 2, 1521–1529.

11) Poli, J., Tsaponina, O., Crabbe, L., Keszthelyi, A., Pantesco, V., Chabes, A., Lengronne, A., and Pasero, P. (2012). dNTP pools determine fork progression and origin usage under replication stress. EMBO J. 31, 883-894.

10) Crabbe, L., Thomas, A., Pantesco, V., De Vos, J., Pasero, P., and Lengronne, A. (2010). Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response. Nature Struct. Mol. Biol. 17, 1391–1397.

9) Crabbe, L., and Karlseder, J. (2010). Mammalian Rap1 widens its impact. Nat Cell Biol 12, 733–735.

8) Tuduri, S., Crabbe, L., Tourrière, H., Coquelle, A., and Pasero, P. (2010). Does interference between replication and transcription contribute to genomic instability in cancer cells? Cell Cycle 9, 1886–1892.

7) Tuduri, S., Crabbe, L., Conti, C., Tourrière, H., Holtgreve-Grez, H., Jauch, A., Pantesco, V., De Vos, J., Thomas, A., Theillet, C., et al.(2009). Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol 11, 1315–1324.

6) Crabbe, L., Jauch, A., Naeger, C.M., Holtgreve-Grez, H., and Karlseder, J. (2007). Telomere dysfunction as a cause of genomic instability in Werner syndrome. PNAS 104, 2205–2210.

5) Verdun, R.E., Crabbe, L., Haggblom, C., and Karlseder, J. (2005). Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell 20, 551–561.

4) Crabbe, L., and Karlseder, J. (2005). In the end, it's all structure. Curr. Mol. Med. 5, 135–143.

3) Crabbe, L., Verdun, R.E., Haggblom, C.I., and Karlseder, J. (2004). Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951–1953.

2) Gourdier, I., Crabbe, L., Andreau, K., Pau, B., and Kroemer, G. (2004). Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. Oncogene 23, 7449–7457.

1) Gourdier, I., Del Rio, M., Crabbe, L., Candeil, L., Copois, V., Ychou, M., Auffray, C., Martineau, P., Mechti, N., Pommier, Y., et al. (2002). Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. FEBS Lett 529, 232–236.